Integrated COVID-19 Predictor: Differential expression analysis to reveal potential biomarkers and prediction of coronavirus using RNA-Seq profile data통합 COVID-19 예측자: RNA-Seq 프로필 데이터를 사용하여 잠재적인 바이오마커 및 코로나바이러스 예측을 밝히기 위한 차등 발현 분석Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, [키워드] Accuracy adjusted Analysis applied association bioinformatics Biomarker classification Classifier collected Consensus Control coronavirus COVID-19 COVID-19 cases COVID-19 pandemic DEGs DESeq2 Differential expression analysis differentially expressed gene Differentially expressed genes disease transmission down-regulated genes experiment experimental analysis expressed feature filtered gene count Genome healthy identify input intersection and union issue Limma machine machine learning machine learning model machine learning models matter moderate P-value pandemic performed Potential biomarker potential biomarkers predict prediction predictor processed RNA-Seq SARS-CoV-2 SARS-CoV-2 virus sequence significantly Spread statistical SVM the SARS-CoV-2 virus trend up-regulated viral disease Virology [DOI] 10.1016/j.compbiomed.2022.105684 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways Research Published on 2022-05-022022-10-05 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] airway Alter approach Cell cell interaction Ciliated epithelial cells colonic complex disease driving epithelial epithelial cell Evidence experimental analysis Gut ileal immune cell populations immune response Impact Increasing Infection Inflammation Inflammatory responses Interaction intercellular intestinal Local mapping methodology molecular target Organoid SARS-CoV-2 SARS-COV-2 infection single-cell RNA-seq systemic immune response upper airway viral infection [DOI] 10.1038/s41540-022-00224-x [Article Type] Research
Applied behavioral economics and public health policies: Historical precedence and translational promiseResearch article Published on 2022-05-012022-10-05 Journal: Behavioural Processes [Category] 비임상, [키워드] advance alcohol approach baseline behavioral economics COVID-19 vaccine decrement defend Demand Discounting effort example experimental analysis implication Preventive medicine psychometric properties public health translational widespread [DOI] 10.1016/j.beproc.2022.104640 [Article Type] Research article
Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis StudyProtocol Published on 2022-01-252022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] Activation acute respiratory distress Analysis anamnestic Antigen antigens approved biochemical Blood blood monocyte CD4+ CD8+ T cell CD8+ T cells clinical analysis Clinical data collected Comorbidities Complete COVID-19 Cytokines detect develop Enrollment epidemiological Epidemiology ethics committee experimental analysis factor serum Factors function generate Genetic genetics healthy healthy subject help high mortality rate hyperactivity Hypothesis Identifier identify immune Immune cell immune response immune system Immunity immunological immunological profile immunology immunomodulation immunomodulatory implementation independent Infection Infectious disease initial innate immune response Laboratory lymphocyte mechanism monocyte Monocytes mononuclear cells natural killer cell Natural killer cells Novel coronavirus objective Patient patients patients older Peripheral blood Pfizer phenotype Population proof protection Protective protocol recognize Registration report Result risk SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 severe SARS-CoV-2 stimulate syndrome Testing therapeutic vaccination Vaccine viral infection virus White blood cell younger people [DOI] 10.2196/29892 PMC 바로가기 [Article Type] Protocol
Investigation of Thiocarbamates as Potential Inhibitors of the SARS-CoV-2 MproCommunication Published on 2021-11-122022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Accuracy applied approach Compound Computational study drug design evaluate experimental analysis higher affinity investigation Modification MPro MST Potential SARS-CoV-2 Mpro tested the SARS-CoV-2 Thiocarbamate thiocarbamates [DOI] 10.3390/ph14111153 PMC 바로가기 [Article Type] Communication
The first report of iron-rich population of adapted medicinal spinach ( Blitum virgatum L.) compared with cultivated spinach ( Spinacia oleracea L.)Article Published on 2021-11-122022-10-04 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] addition Affect Antiviral Biological techniques Blood Characteristics Chenopodiaceae collagen conditions COVID-19 pandemic crown Culture determine disease Ecology Evidence experimental analysis FIVE immune function infections Local lung mass neurotransmitter New oxygen performed Physiology plant Plant sciences Pneumonia Population Prevalence protection Research selected union was used [DOI] 10.1038/s41598-021-01113-9 PMC 바로가기 [Article Type] Article
Deep Learning Algorithm for COVID-19 Classification Using Chest X-Ray Images흉부 X선 영상을 사용한 COVID-19 분류를 위한 딥 러닝 알고리즘Comparative Study Published on 2021-11-092022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approach Chain Reaction Characteristics chest X-ray Chest X-ray image Chest X-ray images classification CNN CNNs Convolutional neural networks coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 diagnosis CXR dataset deep Diagnosis disease disease classification Diversity early diagnosis eight epidemic curve experimental analysis feature Features generative adversarial networks Government Image learning offer overcome pandemic Pneumonia provide Radiography recent Research respiratory resulting Reverse transcription-polymerase chain reaction RT-PCR SARS-CoV-2 Spread the epidemic toolkit training data triggered X-ray [DOI] 10.1155/2021/9269173 PMC 바로가기 [Article Type] Comparative Study
An optimized KELM approach for the diagnosis of COVID-19 from 2D-SSA reconstructed CXR ImagesResearch article Published on 2021-10-012022-10-05 Journal: The British journal of oral & maxillofacial surger [Category] 변종, [키워드] 2-D SSA Accuracy Analysis approach chest X-ray Classifier competent component COVID-19 COVID-19 diagnosis CXR dataset Deep Learning Method Diagnosis diagnosis of COVID-19 ENhance experimental analysis extreme feature GLCM high mortality rate Image Infectious disease invasive KELM Kernel Non-invasive normal outperform parameter reconstructed RT-PCR test SSA time-consuming [DOI] 10.1016/j.ijleo.2021.167572 [Article Type] Research article
Future Forecasting of COVID-19: A Supervised Learning ApproachArticle Published on 2021-05-112022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, SARS, [키워드] Accuracy Administered Algorithm body temperature breathing problems chest pain consequence Contamination COVID-19 COVID-19 infected patient COVID-19 pandemic COVID-19 virus diagnose Diagnosis diagnosis of COVID-19 diarrhea dose dry cough evaluated expected experimental analysis Features flu Forecasting Future headache Immunity joint learning Metrics Pain positive Precision predict Probability Random forest recall shown Spread statistical analysis supervised learning Symptoms the WHO these symptom Vaccine virus vomiting [DOI] 10.3390/s21103322 PMC 바로가기 [Article Type] Article