Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validationarticle Published on 2023-06-122024-09-05 Journal: Journal of Translational Medicine [Category] update2024, [키워드] diabetic kidney disease experimental validation molecular docking network pharmacology resveratrol [DOI] 10.1186/s12967-023-04233-0 PMC 바로가기 [Article Type] article
Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathwayArticle Published on 2023-01-302022-11-15 Journal: Journal of ethnopharmacology [Category] 유전자 메커니즘, 진단, [키워드] Activation acute lung injury ALI model alleviate Analysis attenuate Baidu caused Cell cellular China component Component analysis components Compound COVID-19 COVID-19 patients demonstrated experiment experimental validation Formula in vivo increases in indicated Inflammation ingredient inhibited inhibiting Kyoto lung Lung injury material mechanism of action Mild molecular mechanism network network pharmacology NF-κB pathway NF-κB signaling NF-κB signaling pathway Obstructive Ontology p-NF-κB p65 pathway pharmacological predicted proinflammatory Proteins reduced syndrome target treat Treatment Xuanfei baidu formula. [DOI] 10.1016/j.jep.2022.115833 PMC 바로가기
Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] absorbed acute respiratory syndrome aerosolized hydrogen peroxide Aerosols Bacterial baseline Biosafety Level 3 BSL3 Care Clinical use comparable coronavirus COVID-19 COVID-19 pandemic coxsackievirus Critical CURIS decontamination develop Disinfection effective Efficiency evaluated experimental validation External filtering facepiece (FFP) respirators (FFR) filtration fit-testing greater Health Health care worker herpes simplex HSV-1 hydrogen hydrogen peroxide inactivation include indicated limit limitation Multiple N95 respirator N95 respirators occupational pandemic pathogen peroxide Personal protective equipment Protective provided Quantitative Research Respirator respirators respiratory droplet Result reuse Safe Safety SARS-CoV-2 SARS-CoV2 spores Sterilization These data transmitted Treatment viral inactivation virologic testing virus while [DOI] 10.1128/msphere.00303-22 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens Research Published on 2022-06-302022-10-05 Journal: NPJ Digital Medicine [Category] 신약개발, 임상, 치료법, 치료제, [키워드] adjusted B.1.351 B.1.617.2 Beta candidate drug clinically clinician combination regimen combination therapy combinations Community COVID-19 Delta drug combination Drug interactions Efficacy EIDD-1931 experimental validation Infectious disease Live virus pandemic platform Rapid regimen representing SARS-CoV-2 SARS-CoV-2 variant therapy translation Vero E6 was used [DOI] 10.1038/s41746-022-00627-4 [Article Type] Research
Commentary on “Poor evidence for host-dependent regular RNA editing in the transcriptome of SARS-CoV-2”"SARS-CoV-2의 전사체에서 숙주 의존적 정규 RNA 편집에 대한 불충분한 증거"에 대한 논평Article Published on 2022-05-012022-09-11 Journal: Journal of applied genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ADAR ADARs Analysis APOBEC APOBECs cellular RNA changes criticism Evidence excess experimental validation explain form genetic change genetic variability Host Hypothesis in viral involved RNA RNA editing SARS-CoV-2 SARS-CoV-2 transcriptome shown similarities similarity the SARS-CoV-2 Transcriptome Variability viral genome viral replication Viral RNA viruses while [DOI] 10.1007/s13353-022-00688-x PMC 바로가기 [Article Type] Article
Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine DesignSARS-CoV-2 백신 디자인을 위한 후보 T-세포 에피토프를 예측하기 위한 컴퓨터 기반 면역정보 분석Article Published on 2022-03-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity allele Antigen B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 binding free energy Brazil candidate caused change Chinese clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 effective epitope Epitopes evaluated Evidence experimental validation free energy HLA HLA-A human leukocyte antigen immune mechanism IMPROVE Inclusion India less leukocyte molecular molecular docking mutate mutated Mutation neutralizing antibody New outbreak overlapping P.1 pandemic peptide peptides predict predicted Prevalence problem residue S protein S-protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection selected severe acute respiratory syndrome Coronavirus South Africa Spike protein strain T-cell T-cell epitopes therapy United Kingdom Vaccine Vaccine design Vaccine development Vaccines virus virus genomes virus infection was used [DOI] 10.3389/fimmu.2022.847617 PMC 바로가기 [Article Type] Article
Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling화학 구조 및 생물학적 활성 기반 모델링을 사용한 Anti-SARS-CoV-2 화합물의 효율적인 식별Article Published on 2022-03-242022-09-11 Journal: Journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] 3CL acting anti-SARS-CoV-2 antiviral activities antiviral activity approach Biological characteristic Chemical chymotrypsin complementary Compound compound screening Drug discovery Efficiency efficient entry of SARS-CoV-2 expand experimental validation fold human host cell human host cells identification identify IMPROVE inhibitor Live virus machine learning model machine learning models modeling protease Protease inhibitor receiver receiver operating characteristic SARS-CoV-2 speed Structure the SARS-CoV-2 viral entry [DOI] 10.1021/acs.jmedchem.1c01372 PMC 바로가기 [Article Type] Article
Plant-Derived Antiviral Compounds as Potential Entry Inhibitors against Spike Protein of SARS-CoV-2 Wild-Type and Delta Variant: An Integrative in SilicoApproachSARS-CoV-2 야생형 및 델타 변이체의 스파이크 단백질에 대한 잠재적 진입 억제제로서의 식물 유래 항바이러스 화합물: SilicoApproach의 통합Article Published on 2022-03-082022-09-11 Journal: Molecules [Category] SARS, 변종, 신약개발, 진단, 치료제, [키워드] antagonists Antiviral Antiviral agents antiviral drug antiviral drugs approach approaches binding affinities binding affinity binding energy binding free energies binding free energy binding interaction carried complexes Compound compounds controls Corilagin country COVID-19 COVID-19 infection Delta delta variant develop docking Efficacy exhibited experimental validation explained FIVE free energies glycoprotein greater H-bonds hydrogen hydrophobic interaction hydrophobic interactions Hypericin in silico India lead Ligand ligands Lupeol molecular molecular docking molecular dynamics molecular dynamics and simulations Molecular modeling mutated phytochemical compounds plant compound Potential Protein Research resulting RMSD RMSF S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant second wave selected several variant several variants spike spike glycoprotein Spike protein stability target proteins therapeutic intervention Transmissibility Vaccine Virtual screening virulence was performed while wild-type wild-type SARS-CoV-2 [DOI] 10.3390/molecules27061773 PMC 바로가기 [Article Type] Article