Toward better diabetes care: Exploration and implementationMini Review Published on 2023-02-102024-09-05 Journal: Journal of Diabetes Investigation [Category] update2024, [키워드] diabetes care exploration implementation [DOI] 10.1111/jdi.13978 PMC 바로가기 [Article Type] Mini Review
Host genomics of SARS-CoV-2 infectionSARS-CoV-2 감염의 숙주 유전체학Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19 [DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection폐포 대식세포: SARS-CoV-2 감염의 아킬레스건Review Published on 2022-07-192022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Achille Acidic acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar macrophage Alveolar macrophages alveoli Antiviral compound Antiviral compounds antiviral drug antiviral drugs can not caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosol dampen death Degradation effort endosomal pH endosome Endosomes exploration facilitate gloom Immune cell immune cells individuals infected individuals initiate lysosomal macrophages modulation Neutralizing antibodies neutralizing antibody pandemic prophylactically Replication respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus specificity Spread treat Vaccine viral escape viral mutation virus viruses [DOI] 10.1038/s41392-022-01106-8 PMC 바로가기 [Article Type] Review
Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland샘에서 바이러스 검출과 독립적으로 COVID-19로 사망한 피험자의 뇌하수체 호르몬 유전자 억제Article Published on 2022-07-142022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACTH adrenocorticotropic adrenocorticotropic hormone Antigen antigens cardiac death Cell Chain Reaction changes in clinically controls COVID-19 COVID-19 case COVID-19 group cytotoxic cell death deficiency detection died direct viral infection dysfunction evaluate exploration expression Gene Expression Genes gland hormone Hormones hospitalized patients hypophysis immune immunohistochemistry In situ hybridization investigated Involvement Level mRNA transcript mRNA transcripts neurohypophysis neutrophil Patient PCR Pituitary pituitary apoplexy pituitary gland pituitary hormone pituitary hormones. polymerase chain polymerase chain reaction Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection searched serum severe COVID-19 Signaling subject sudden cardiac death suggested Support suppressed suppression the SARS-CoV-2 genome transmission electron microscopy trauma tropism tropism of SARS-CoV-2 type I interferon Viral viral genome viral infection virus were measured [DOI] 10.1210/clinem/dgac312 PMC 바로가기 [Article Type] Article
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19COVID-19에 대한 작용 기전으로서 SARS-CoV-2 N 단백질의 비천연 단백질-단백질 상호작용의 소분자 안정화Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료법, [키워드] absence addition Affect analyzed applicability catechin caused Compound coronavirus COVID-19 docking drug design Drug discovery effective exploration identify inhibit mechanism mechanism of action MERS MERS-CoV molecular molecular dynamics NTD nucleocapsid protein outbreak protein-protein interaction protocol reported Research residue responsible SARS-CoV-2 SARS-CoV-2 N protein small molecule the disease Treatment viral replication Virtual screening [DOI] 10.1080/07391102.2020.1860828 PMC 바로가기 [Article Type] Article
Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype OntologyKGEV(Knowledge Graph Exploration and Visualization)용 웹 프레임워크를 통한 신속한 지식 습득: COVID-19 및 인간 표현형 온톨로지에 대한 사례 연구Article Published on 2022-06-022022-09-12 Journal: BMC Medical Informatics and Decision Making [Category] MERS, 진단, [키워드] acquisition computational method computational tool COVID-19 COVID-19 pandemic Data visualization database dataset demonstrated downstream eight emerging disease exploration facilitate filtration FIVE generate heterogenous Human human disease hypotheses information Information extraction knowledge Knowledge discovery Knowledge graph Knowledge graph. lack Metadata phenotypic question reliability Research shortest path Support utility Visualization [DOI] 10.1186/s12911-022-01848-z PMC 바로가기 [Article Type] Article
CoV2K model, a comprehensive representation of SARS-CoV-2 knowledge and data interplayCoV2K 모델, SARS-CoV-2 지식 및 데이터 상호 작용의 포괄적 표현Article Published on 2022-06-012022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 변종, [키워드] Abstract aggregate API co-occurrence COVID-19 pandemic domain Effects Evolution exploration Genome graph information interactions knowledge organization outbreak provide Research resource resources SARS-CoV-2 SARS-CoV-2 virus the SARS-CoV-2 variants Viral mutations while [DOI] 10.1038/s41597-022-01348-9 PMC 바로가기 [Article Type] Article
Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida, Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme아일랜드 심해 연성 산호 Duva florida의 메로테르펜인 Tuaimenal A, SARS-CoV-2 3CLpro 효소 억제 표시Review Published on 2022-05-272022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Bioactivity biochemical assay carbon Cold collected Continental margin Coral display docking experiment exploration human disease in silico inhibit inhibition invertebrate margin Meroterpene metabolome protease representing SARS-CoV-2 Soft the SARS-CoV-2 was determined water [DOI] 10.1021/acs.jnatprod.2c00054 PMC 바로가기 [Article Type] Review
Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S ProteasomeSARS-CoV-2 주요 프로테아제 및 20S 프로테아좀의 공유 억제제의 절대 결합 자유 에너지의 빠르고 효과적인 예측Article Published on 2022-05-042022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerated activities Amino acid applicability approach binding affinities binding affinity binding free energy cause computational method covalent bond COVID-19 COVID-19 pandemic Degradation drug Effect effective electrophilic energetics energy enzyme evaluate exploration Free globe inhibitor inhibitors inhibitors of SARS-CoV-2 interactions M pro modulation powerful tool prediction protease proteasome Protein protocol public health emergency reaction reservation robust SARS-CoV-2 shown significantly target Therapeutic strategies variant warhead water [DOI] 10.1021/jacs.2c00853 PMC 바로가기 [Article Type] Article