expression patterns – Communicable Diseases Research

A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression

2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식

Article

Published on 2022-06-012022-08-31
Journal: Omics : a journal of integrative biology
[Category] MERS, 신약개발, 유전자 메커니즘,

The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease

COVID-19 질병의 급성기에서 후기 급성기 MALAT1, NEAT1, THRILL 및 miR-155-5p의 발현 패턴

Article

Published on 2022-05-012022-09-11
Journal: The Brazilian journal of infectious diseases : an
[Category] COVID19(2023년), SARS, 바이오마커, 진단,

[키워드] acute COVID-19 acute phase addition Analysis Biomarker COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 infection diagnose diagnosis of COVID-19 disease evaluated expression level expression levels expression pattern expression patterns hallmark hallmarks healthy control healthy individual Infection Inflammation Inflammatory factor inflammatory factors Long Long non-coding RNAs MicroRNAs microRNAs. miR-150 miR-155 MONITOR mononuclear cell ncRNA ncRNAs non-coding RNA Non-coding RNAs Pathogenesis pathogenesis of COVID-19 Patient PBMC peripheral Peripheral blood real-time PCR assay RNA ROC Curve selected severity of COVID-19 significantly increased significantly lower the SARS-CoV-2 THRIL Total total RNA
[DOI] 10.1016/j.bjid.2022.102354 PMC 바로가기 [Article Type] Article

Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 Patients

COVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화

Article

Published on 2022-04-152022-09-11
Journal: Journal of immunology (Baltimore, Md. : 1950)
[Category] 유전자 메커니즘,

[키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased
[DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article

Novel suction-based in vivo cutaneous DNA transfection platform

Research Article

Published on 2021-11-052022-10-28
Journal: Science Advances
[Category] COVID-19, MERS, SARS,

Genetic and epigenetic control of ACE2 expression and its possible role in COVID-19

ACE2 발현의 유전적 및 후성적 조절과 COVID-19에서의 가능한 역할

Review

Published on 2021-08-012022-09-11
Journal: Cell biochemistry and function
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 caused Cell cell type Clinicians conducted contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease DNA methylation enzyme Epigenetic explain expressed expression expression pattern expression patterns Factors Gene Expression gene expression. Genetic variant genetic variants Health Infection marker mechanism mechanisms MicroRNAs pandemic post-translational modification researcher SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sex shown single-nucleotide polymorphism SNP SNPs Structural variation the SARS-CoV-2
[DOI] 10.1002/cbf.3648 PMC 바로가기 [Article Type] Review

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

대 기도 상피에서 COVID-19 관련 유전자의 발현에 영향을 미치는 유전 적 및 비 유전 적 요인

Multicenter Study

Published on 2021-04-212022-09-10
Journal: Genome Medicine
[Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 binding ACE2 expression ACE2 gene active smoking affecting airway airway epithelium analyzed association Asthma Bronchial epithelium cardiovascular disease cause change chronic obstructive chronic obstructive pulmonary disease clinically Cohort cohorts contribute COPD COVID-19 COVID-19 severity COVID-19 susceptibility Defense determine disease course driven by enrichment analysis environmental factor epithelial eQTL eQTL mapping Evidence expression expression pattern expression patterns Factor Factors Gene Expression Gene Set Enrichment Analyses Genetic genetic factors Genetic variant Genetic variation Host host response hypertension identify immune response implicated individuals Inflammation inter-individual interferon investigated involved isoform non-binding obesity obstructive pulmonary disease performed phenotypic provide pulmonary disease Quantitative Regulation Regulatory replicated respiratory respiratory infections respiratory viruses Result risk factor RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data smoker Smokers smoking subsequent supplementary material suppressed susceptibility the SARS-CoV-2 virus These data uninfected Variability variant variants Variation viruses
[DOI] 10.1186/s13073-021-00866-2 PMC 바로가기 [Article Type] Multicenter Study

The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish

Methods & Techniques

Published on 2021-03-152022-10-27
Journal: Biology open
[Category] COVID-19,

[키워드] Danio rerio analysis Ang II Angiotensin II Apelin blood pressure cause Cell cell type cleaving common cold coronavirus Comorbidity component components conducted Conserved synteny contribute coronavirus coronavirus SARS-CoV-2 COVID-19 Danio degrade diabetes disease Effects Enterocyte enzyme exacerbated expressed expressing expression expression patterns Genes Genome duplication genomic HCoV-229E help hypertension identify Infection intestinal cell investigated mechanism MERS-CoV Middle East obesity ortholog outcome peptide phylogenetic analysis produced PROTECT RAAS receptor receptors regulate respiratory respiratory inflammation Result SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq Single Cell single-cell specific type subtype susceptible System the SARS-CoV-2 transcriptomes transcriptomics underlying conditions Vascular virus zebrafish
[DOI] 10.1242/bio.058172 PMC 바로가기 [Article Type] Methods & Techniques

The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish

Methods & Techniques

Published on 2021-03-152022-10-27
Journal: Biology open
[Category] Coronavirus, COVID-19, Fulltext, SARS,

[키워드] Danio rerio analysis Ang II Angiotensin II Apelin blood pressure cause Cell cell type cleaving common cold coronavirus Comorbidity component components conducted Conserved synteny contribute coronavirus coronavirus SARS-CoV-2 COVID-19 Danio degrade diabetes disease Effects Enterocyte enzyme exacerbated expressed expressing expression expression patterns Genes Genome duplication genomic HCoV-229E help hypertension identify Infection intestinal cell investigated mechanism MERS-CoV Middle East obesity ortholog outcome peptide phylogenetic analysis produced PROTECT RAAS receptor receptors regulate respiratory respiratory inflammation Result SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq Single Cell single-cell specific type subtype susceptible System the SARS-CoV-2 transcriptomes transcriptomics underlying conditions Vascular virus zebrafish
[DOI] 10.1242/bio.058172 PMC 바로가기 [Article Type] Methods & Techniques

Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19

임상 분석 및 만능 줄기 세포 기반 모델은 COVID-19에 취약한 유아에 대한 ACE2 및 폐 전구 세포의 가능한 영향을 보여줍니다

Multicenter Study

Published on 2021-01-012022-09-01
Journal: Theranostics
[Category] 진단, 치료기술,

[키워드] ACE2 ACE2 ACE2 expression age Alveolar Type II analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsies Cell cells children children with COVID-19 clinical clinical feature Clinical features Cohort Combination contributing to cooperation coronavirus disease Coronavirus disease 2019 COVID-19 derivative develop developmental developmental stages disease severity distribution double positive cell double positive cells Ex vivo examined expressed expression expression level expression levels expression pattern expression patterns immune response immune system Impact Infant Infants infections lung lung biopsies lung cell lung cells lung development lung injuries Lung injury lung progenitor cells Lungs number of children Older pluripotent stem cells Pneumonia positive profiles progenitor cell progenitor cells reported risk factor Risk factors RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus severe coronavirus disease significantly single cell RNA sequencing SOX9 Spectrum Stage stem cell Type vulnerability with COVID-19
[DOI] 10.7150/thno.53136 PMC 바로가기 [Article Type] Multicenter Study

SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease

당뇨병 및 COVID-19 관련 신장 질환의 SARS-CoV-2 수용체 네트워크

Article

Published on 2020-12-012022-09-11
Journal: Kidney international
[Category] SARS, 유전자 메커니즘,

[키워드] ACE ACE inhibitors ACE2 ACE2 expression ACE2 receptor acute kidney Acute kidney injury aldosterone Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bayesian biopsy Cell cellular COVID-19 dataset diabetes Diabetic diabetic kidney diabetic nephropathy Donor endomembrane epithelial epithelial cell epithelial cells expression expression pattern expression patterns healthy hospitalized patient host cells immune activation In situ hybridization infected cells Infection inhibitor Integrative analysis investigated kidney kidney damage Kidney disease kidneys living donors mechanism medication medications molecular molecular networks morbidity morbidity and mortality overlapped Patient patients with diabete proximal proximal tubules Renin renin-angiotensin-aldosterone system Research risk stratification RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected cells scRNAseq scRNAseq. susceptibility the SARS-CoV-2 Therapeutic strategies therapeutic strategy Urine Viral viral entry with COVID-19
[DOI] 10.1016/j.kint.2020.09.015 PMC 바로가기 [Article Type] Article