Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significanceArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Antiviral biological processe China complications death disease Evidence extreme feasible Giving globe immune reaction increase Infection mechanism Molecular biology ncRNA ncRNAs non-coding RNA noncoding RNA Pathogenesis pathogenic virus preventing infection Progress Research resulting RNA SARS-CoV-2 SARS-CoV2 Spread subsequent Symptoms therapeutic therapy virus virus infection [DOI] 10.1016/j.ijbiomac.2022.09.105 PMC 바로가기
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Temporal Events Detector for Pregnancy Care (TED-PC): A rule-based algorithm to infer gestational age and delivery date from electronic health records of pregnant women with and without COVID-19Article Published on 2022-10-312022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy age Algorithm Characteristics chronic obstructive clinical information Cohort combating common COVID COVID-19 COVID-19 pandemic Critical detect Detector develop diabete distress EHR Electronic health record event extreme gestation granularity Health identifying information material Model normalized obesity outcomes partnership performed Pregnancy pregnant women Prevalence pulmonary disease Record Respiratory failure resulting SARS-COV-2 infection SARS-CoV-2 viral infection Support syndrome Temporal the timing Validity viral infection with COVID-19 [DOI] 10.1371/journal.pone.0276923 PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기
The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) AthensArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 진단, [키워드] Abstract addition addressed AUTO13 autoantibodies Autoimmune Autoimmune disease Autoimmunity correlated correlation Course COVID-19 COVID-19 vaccine Critical Cytokine storm diagnostics disease Diseases example extreme Immunosuppressant International involved mechanism morbidity Mortality organ pandemic participant Pathways patients with COVID-19 SARS-CoV-2 severity syndrome systemic lupus erythematosus Systemic sclerosis the disease Therapies therapy while [DOI] 10.1016/j.autrev.2022.103166 PMC 바로가기
Ginkgo biloba in the management of the COVID-19 severityArticle Published on 2022-10-012022-11-15 Journal: Archiv der Pharmazie [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome aggregation alleviate Anti-inflammatory antioxidant Antiviral Antiviral effect attenuate booster complementary complementary medicine complications coronavirus disease Coronavirus-2 COVID-19 COVID-19 severity Critical drug Effect Effectiveness extreme Ginkgo Ginkgo biloba impede Infection inflammatory disorder management mechanisms nanomedicines Neutrophil elastase offer oxidative stress Platelet proinflammatory cytokines protease Proteases provide SARS-CoV-2 symptomatic syndrome therapy thrombosis viral proteases [DOI] 10.1002/ardp.202200188 PMC 바로가기
Circulating multimeric immune complexes contribute to immunopathology in COVID-19Article Published on 2022-09-262022-11-15 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료제, [키워드] activating Activation Antiviral circulating comparable contribute COVID-19 COVID-19 progression Critical detrimental disease driven by dysregulated immune response Evidence extreme FcγRs humoral identify IgG IgG response immune complex immunopathology independent Intervention Ligand mitigate paradoxical Patient patients Protective reporter robust SARS-CoV-2 severe COVID-19 SLE specific IgG antibody systemic immune dysregulation systemic lupus erythematosus triggering with mild disease [DOI] 10.1038/s41467-022-32867-z PMC 바로가기
Multiple introduced lineages and the single native lineage co-driving the four waves of the COVID-19 pandemic in West AfricaArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Beta Cases conducted Coronavirus disease 2019 country COVID-19 COVID-19 pandemic death death rate deaths Delta eight epidemiological Eta extreme four waves. Gamma GDP Genome global pandemic heterogeneous incidence rates introduced Iota Liberia Lineage measure MOST Multiple Nigeria omicron pandemic positive rate public health quarantine recorded reported Retrospective analysis SARS-CoV-2 SARS-CoV-2 variant second wave spread of COVID-19 Surveillance the epidemic Transmission dynamics variant were recorded West West Africa [DOI] 10.3389/fpubh.2022.957277 PMC 바로가기
Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective studyArticle Published on 2022-09-132022-11-15 Journal: eLife [Category] SARS, 진단, 치료기술, [키워드] 95% CI Admission baseline Capacity changed clinical COG-UK collected conducted COVID-19 COVID-19 infection detect Epidemiology evaluated Evidence extreme global health HAI Health Service Healthcare-associated infection hospital Hospital-acquired infection Human incidence incidence rate Infection infection control Infection prevention Infectious disease Innovation Intervention knowledge Limited Medical Research Council Microbiology molecular Molecular epidemiology MRC NIHR non-randomised trial nosocomial outbreak per-protocol Prospective Study resources respond returned SARS-CoV-2 SARS-CoV-2 genome sequencing sensitivity analysis sequence Sequencing Site statistically significant supported Transmission Trial viral genomics Volume Wellcome Sanger Institute were recorded while [DOI] 10.7554/eLife.78427 PMC 바로가기
Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional surveyArticle Published on 2022-09-082022-11-15 Journal: PLoS Medicine [Category] SARS, 진단, [키워드] 95% confidence interval Adults age and gender attributes black Brazil Brown children Cohort contribute coronavirus 2 country COVID-19 COVID-19 pandemic cross-sectional cross-sectional survey cumulative determinant distribution employment extreme Factor female Generalizability highest IgG incidence Infection interquartile range IQR limit main outcome measure male median median age median size men mitigate observation pandemic participant Participation performed physical random intercept reported respiratory risk Risk factors Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 seroprevalence second wave Sensitivity and specificity serology seropositive Serosurvey Spike protein study population targeted intervention the SARS-CoV-2 threshold Transmission women [DOI] 10.1371/journal.pmed.1004093 PMC 바로가기