Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity
폐 계면활성제의 감소된 DMPC 및 PMPC는 비만에서 SARS-CoV-2 감염을 촉진합니다
Article
[키워드] ACE2
ACE2 expression
ACE2 receptor
Analysis
BALF
bind
Bronchoalveolar lavage fluid
cell-cell fusion assay
characterized
cholesterol
COVID-19
COVID-19 disease
COVID-19 pneumonia
D614G mutant SARS-CoV-2
Defense
DMPC
Effect
effector cells
elevated
expressing
fat
Feeding
HEK293T
HEK293T cell
HEK293T cells
High fat diet
Hospitalization
increased risk
Increasing
Infection
infections
inhibited
inhibitory effect
Inhibitory effects
Lipid
lipid composition
lipid metabolism
lipids
lung
lung surfactant
lung tissue
Lungs
mechanism
metabolism
mice
myristic acid
obese
obesity
outcomes
overexpression
Phosphatidylcholine
Pneumocytes
produced
promote
Protein
reduced
respiratory virus
reversed
risk factor
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pseudovirus infection
SARS-CoV-2 viral loads
severe COVID-19 disease
Severe COVID-19 pneumonia
Spike protein
surfactant
the Spike
Triglyceride
triglycerides
trimyristin
Type II pneumocyte
type II pneumocytes
Vero-E6 cell
Vero-E6 cells
was performed
were used
wild type
[DOI] 10.1016/j.metabol.2022.155181 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.metabol.2022.155181 PMC 바로가기 [Article Type] Article