Ferritin nanocages as efficient nanocarriers and promising platforms for COVID-19 and other vaccines developmentReview Published on 2023-03-012023-07-11 Journal: Biochimica et biophysica acta. General subjects [Category] COVID19(2023년), [키워드] Antigen bioengineering COVID-19 drug delivery ferritin Nanoparticles vaccine. [DOI] 10.1016/j.bbagen.2022.130288 PMC 바로가기 [Article Type] Review
Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 PneumoniaArticle Published on 2023-01-012023-07-09 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), [키워드] Biomarkers COVID-19 ferritin intensive care unit. [DOI] 10.1177/08850666221113252 PMC 바로가기
Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational studyObservational Study Published on 2022-12-042023-07-10 Journal: European Journal of Medical Research [Category] COVID19(2023년), [키워드] Bilirubin COVID-19 ferritin heme Heme oxygenase one sepsis. [DOI] 10.1186/s40001-022-00915-5 PMC 바로가기 [Article Type] Observational Study
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
COVID-19 and the injured patient: A multicenter reviewResearch article Published on 2022-12-012022-10-05 Journal: The Journal of surgical research [Category] 바이오마커, [키워드] adverse events Affect age Analysis baseline characteristics C-reactive protein Coagulopathy Cohort collected Comorbidities composed Coronavirus disease 2019 COVID-19 cumulative D-dimer demographics diabetes events ferritin Frame Hospitalization hypertension In-hospital death Injury ISS Kaplan–Meier method log-rank test median morbidity and mortality Mortality multicenter neurologic New York Older outcome outcomes Patient patients performed physiological Primary outcome Result Retrospective analysis severity shown study period surgical tested trauma trauma patient trauma patients were excluded were used [DOI] 10.1016/j.jss.2022.06.068 [Article Type] Research article
The intercorrelations between blood levels of ferritin, sCD163, and IL-18 in COVID-19 patients and their association to prognosisArticle Published on 2022-12-012023-07-10 Journal: Immunologic research [Category] COVID19(2023년), [키워드] COVID-19 Cytokine storm ferritin hyperferritinemic syndrome IL-18 macrophage activation syndrome SARS-CoV-2 sCD163. [DOI] 10.1007/s12026-022-09312-w PMC 바로가기
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccineArticle Published on 2022-10-232022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] adjuvant anticipated Beta COVID-19 Delta delta variant domain effective ferritin Heterologous highest Immunity induce Infection mice mutations neutralization neutralization titer neutralizing antibody NHP NHPs non-human primate omicron PROTECT pseudovirus reported sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variants SARS-related viruses Vaccine variant [DOI] 10.1038/s41467-022-33985-4 PMC 바로가기
Sex differences in determinants of COVID-19 severe outcomes – findings from the National COVID Cohort Collaborative (N3C)Article Published on 2022-10-122022-11-15 Journal: BMC Infectious Diseases [Category] 바이오마커, [키워드] absolute lymphocyte absolute neutrophil adjusted adjusted odds ratio Admission age Analysis association averaged Biomarker Biomarkers both sexes CCI Charlson Comorbidity Index comorbid condition Comorbidities Comorbidity components COVID COVID-19 COVID-19 severity CRP death death rate defined determinant disease Elevation examined ferritin Health highlight hospital Hospitalized IMV Inflammation inflammatory biomarkers Invasive mechanical ventilation lab value Liver disease Logistic regression LOS lymphocytopenia magnitude male medication men men and women moderate to severe Mortality Myocardial infarction N-terminal neutrophil outcome Patient peptide Platelet Platelets predictor previous study Primary outcome procalcitonin Protein remained renal Research retrospective cohort risk risk factor risk of death secondary outcome Sex Sex difference sex differences. significantly solid tumor with COVID-19 women [DOI] 10.1186/s12879-022-07776-7 PMC 바로가기
Procalcitonin and High APACHE (Acute Physiological and Chronic Health Evaluation) Level Are Associated with the Course of Acute Kidney Injury in Patients with SARS-CoV-2Article Published on 2022-10-072022-11-15 Journal: International journal of clinical practice [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age AKI Analysis association average C-reactive protein Cell chronic D-dimer demonstrated diagnosis of SARS-CoV-2 ferritin Hospital admission Hospitalized implicated incidence infected with SARS-CoV-2 Inflammation Inflammatory marker Injury investigated Juan KDIGO kidney Kidney function Kidney injury lactate dehydrogenase Level mechanism outcome Patient patients hospitalized performed phosphate Pneumonia predictor procalcitonin procalcitonin level prospective cohort study RT-PCR SARS-CoV-2 survival systemic inflammation virus were recorded with COVID-19 [DOI] 10.1155/2022/1363994 PMC 바로가기
Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled TrialArticle Published on 2022-10-062022-11-15 Journal: The Journal of Nutrition [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adhesion molecules age anti-inflammatory effect Antigen assigned baseline Biomarker Blood BMI C-reactive protein CDC chronic condition coin toss Concentration conducted Controlled coronavirus disease covariates COVID-19 COVID-19 complications COVID-19, SARS-COV-2 Cytokines diagnosed with COVID-19 Diagnosis dietary supplements double-blind dysregulated immune response Effect exacerbate ferritin group Health IL-1β IL-2 IL-6 implicated indicated individual infected with COVID-19 infections infectious conditions Inflammation inflammatory mediator intercellular Linear regression model mechanism Multiple outcomes P-selectin palmitoylethanolamide palmitoylethanolamide. participant Placebo placebo tablet positive test result Primary outcome produced proinflammatory promote randomized placebo-controlled trial Randomly receive reduced reported RT-PCR secretion severity Sex significantly stratified treatment effect [DOI] 10.1093/jn/nxac154 PMC 바로가기