Ferrocene Derivatives as New Generation of Antimalarial Agents: Opportunity or Illusion?article Published on 2023-12-312024-09-01 Journal: Current Topics in Medicinal Chemistry [Category] 말라리아, [키워드] Drug-resistance drug-sensitive Ferrocene Ferroquine malaria Organometallic compounds Structure-activity relationship [Article Type] article
Structural-activity Relationship of Metallo-aminoquines as Next Generation Antimalarialsarticle Published on 2022-12-312024-09-01 Journal: Current Topics in Medicinal Chemistry [Category] 말라리아, [키워드] Aminoquinolines antimalarial Chloroquine cytotoxicity Ferroquine in vitro in vivo β-hematin inhibition [Article Type] article
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria무작위 이중 맹검 2b상 연구로, 단순한 플라스모디움 팔시파룸 말라리아를 앓고 있는 성인 및 아동에서 페로퀸과 아르테페노멜의 단일 용량 요법의 효능, 안전성, 내약성 및 약동학을 조사합니다.Research Published on 2021-05-192024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] C580Y combination treatment Exposure–response Ferroquine Kelch-13 mutation Parasite clearance Pharmacokinetics/pharmacodynamics resistance vomiting [DOI] 10.1186/s12936-021-03749-4 PMC 바로가기 [Article Type] Research
Lipid Compositions in Infant Formulas Affect the Solubilization of Antimalarial Drugs Artefenomel (OZ439) and Ferroquine during DigestionArticle Published on 2020-07-062024-08-28 Journal: Molecular Pharmaceutics [Category] 말라리아, [키워드] drug solubilization Ferroquine in vitro digestion infant formula lipid compositions milk OZ439 X-ray scattering
Ferrocene-Based Compounds with Antimalaria/Anticancer Activity페로센 기반 화합물의 항말라리아/항암 활성이 있는Review Published on 2019-10-072024-08-11 Journal: Molecules [Category] 말라리아, [키워드] Cancer ferrocene compounds Ferroquine malaria organometallics [DOI] 10.3390/molecules24193604 PMC 바로가기 [Article Type] Review
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study페로퀸의 안전성과 효능을 평가하기 위한 2상 파일럿 시험: 유도된 혈액 단계 말라리아 감염 연구에서 초기 플라스모디움 팔시파룸에 대한 연구Research Published on 2016-09-132024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Drug discovery Ferrochloroquine Ferroquine Induced blood-stage malaria (IBSM) malaria Pharmacokinetic/pharmacodynamic modelling Plasmodium falciparum SSR97193 Translational models [DOI] 10.1186/s12936-016-1511-3 PMC 바로가기 [Article Type] Research
Ferroquine and its derivatives: new generation of antimalarial agentsarticle Published on 2015-08-312024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] Chloroquine-bridged ferrocenophanes Ferrocene dual conjugates Ferroquine Ferroquine derivatives Future perspectives Hydroxyferroquines [Article Type] article
Quinine conjugates and quinine analogues as potential antimalarial agentsarticle Published on 2015-06-302024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] Chloroquine Ferroquine heterocycles hybrid drugs malaria Quinine [Article Type] article
The ferroquine antimalarial conundrum: redox activation and reinvasion inhibitionArticle Published on 2013-07-222024-08-28 Journal: Angewandte Chemie (International Ed. in English) [Category] 말라리아, [키워드] bioorganometallic chemistry Ferroquine malaria Reactive species subcellular imaging.