Single-cell RNA sequencing analysis of lung cells in COVID-19 patients with diabetes, hypertension, and comorbid diabetes-hypertensionEndocrinology Original Research Published on 2023-12-082024-09-05 Journal: Frontiers in Endocrinology [Category] update2024, [키워드] diabetes endothelial cells fibroblasts hypertension SARS-CoV-2 [DOI] 10.3389/fendo.2023.1258646 PMC 바로가기 [Article Type] Endocrinology Original Research
Therapeutic Potential of Adipose-Derived Stem Cell-Conditioned Medium and Extracellular Vesicles in an In Vitro Radiation-Induced Skin Injury ModelArticle Published on 2023-12-072024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] adipose-derived stem cells Extracellular vesicles fibroblasts Radiation Radiotherapy [DOI] 10.3390/ijms242417214 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Fit to dwell in many places – The growing diversity of intracellular Salmonella nichesarticle Published on 2022-08-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 살모넬라증, [키워드] epithelial cells fibroblasts host cell host-pathogen interactions macrophages Salmonella [Article Type] article
Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19Research article Published on 2022-08-242022-10-05 Journal: EBioMedicine [Category] SARS, 진단, 치료기술, [키워드] alveolar damage Analysis Autopsy Bacteria Candida parapsilosis CD8+ T cells CD8+T cells Cell changes in complex correlated COVID-19 COVID-19 case COVID-19 patients DAD diffuse Diffuse alveolar damage disease eight elevated enriched pathway exhibit Extracellular matrix Factor fatal COVID-19 feature fibroblasts finding foundation funding fungi heart heterogeneity histological humoral immune immune cells immunohistochemistry immunological immunopathology implication innate immune response Lung disease lung tissue Lungs Macrophage macrophages management Melinda Gate modulate molecular multiplex occur Patient performed progression quantified Regeneron Pharmaceuticals response SARS-CoV-2 Secondary infection subsequent Support Swedish the disease Transcriptome Treatment strategies [DOI] 10.1016/j.ebiom.2022.104229 [Article Type] Research article
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal [DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases조직간 단세포 기질 아틀라스는 4가지 만성 염증성 질환에서 공유된 병리학적 섬유아세포 표현형을 식별합니다.Article Published on 2022-07-082022-09-11 Journal: Med (New York, N.Y.) [Category] 비임상, [키워드] Activation affected animal model animal models Arthritis atlas atopic dermatitis breath CCL19 chronic inflammatory disease chronic inflammatory diseases Clusters COL3A1 Critical CXCL10 disease Diseases donors exacerbated fibroblast fibroblasts Foundational research heterogeneity Hoffmann-La Roche identify immune individual inflamed tissue Inflammation Inflammatory bowel disease Inflammatory diseases integration interstitial Interstitial lung disease intestinal inflammation intestine joint lack lung Lung disease Lungs mapped organ systems Pathogenesis pathogenic pathway Pathways phenotype Phenotypes pro-inflammatory reveal rheumatoid arthritis Roche salivary gland salivary glands scRNA-seq single-cell Single-cell RNA sequencing Sjögren's syndrome SPARC stromal syndrome synovium therapeutic target ulcerative colitis [DOI] 10.1016/j.medj.2022.05.002 PMC 바로가기 [Article Type] Article
The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL ProteasePolygonum cuspidatum 뿌리 및 뿌리 줄기 추출물은 S-단백질 및 3CL 프로테아제의 억제를 통해 SARS-CoV-2 야생형 및 오미크론 의사형 바이러스의 진입을 차단합니다Article Published on 2022-06-132022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL ACE2 angiotensin Angiotensin-converting enzyme Anti-viral block blocked caused Chinese Compound contagious COVID-19 develop disease effective Efficacy Ethanol Extract fibroblast fibroblasts gallic acid herbal medicine Infection inhibit inhibition Interaction omicron Omicron variant pandemic pharmacological treatment phytochemical Polygoni Cuspidati Rhizoma et Radix Polygonum Protease activity Pseudotyped virus pseudovirus pseudovirus entry Radix receptor responsible resulting rhizome root S-protein SARS-CoV-2 SARS-CoV-2 pseudotyped virus SARS-CoV-2 virus shown Spike protein tested the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Traditional Chinese medicine Treatment Vaccines water wild-type zebrafish zebrafish larvae. [DOI] 10.3390/molecules27123806 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular researchSARS-CoV-2 수용체 ACE2는 마우스 혈관주위세포에서 발현되지만 내피세포에서는 발현되지 않습니다: COVID-19 혈관 연구에 대한 시사점Article Published on 2022-05-102022-09-12 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression Alveolar Type II analyzed angiotensin Angiotensin converting enzyme 2 (ACE2) Brain Bronchial epithelium cells CNS COVID-19 COVID-19 complications COVID-19 pathogenesis endothelial Endothelial cell endothelial cells enzyme Establishing Express expressed fibroblasts heart pericyte increasingly lung mapped mouse model mouse-adapted SARS-CoV-2 not express organ other organs pancrea pericyte pericytes perineurial postnatal development receptor ACE2 Research SARS-CoV-2 SARS-CoV-2 receptor Single-cell RNA-sequencing single-cell RNA-sequencing. the SARS-CoV-2 Vascular vasculature virus [DOI] 10.1016/j.stemcr.2022.03.016 PMC 바로가기 [Article Type] Article
Pseudanabaena galeata CCNP1313-Biological Activity and Peptides ProductionPseudanabaena galeata CCNP1313-생물학적 활성 및 펩티드 생산Article Published on 2022-05-062022-09-11 Journal: Toxins [Category] COVID19(2023년), SARS, 치료기술, [키워드] A549 activity African green monkey Analysis anticancer anticancer activity Antiviral antiviral activities antiviral activity Apoptosis Baltic Sea Breast cancer cancer cell line cancer cell lines cell line complex component Compound cyanobacteria cytotoxicity ecosystem Effect enzyme fibroblasts fraction Fractions green monkey HCoV HCoV-OC43 HCT-8 induction of apoptosis inhibitors kidney less MCF-7 metabolite metabolites new peptides. peptides potent produced Production Pseudanabaena galeata SARS-CoV-2 strain Structure tested TMPRSS2 toxins virus were used [DOI] 10.3390/toxins14050330 PMC 바로가기 [Article Type] Article