Flavonoids as a therapeutical option for the treatment of thrombotic complications associated with COVID-19Review Published on 2023-03-012023-07-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), [키워드] Anticoagulant antiplatelet COVID-19 fibrinolytic flavonoids thrombosis. [DOI] 10.1002/ptr.7700 PMC 바로가기 [Article Type] Review
The synergistic effect and mechanisms of flavonoids and polysaccharides from Houttuynia cordata on H1N1-induced pneumonia in miceArticle Published on 2023-02-102023-06-24 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, [키워드] flavonoids Inflammation Influenza polysaccharides Synergy. [DOI] 10.1016/j.jep.2022.115761 PMC 바로가기
Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘Article Published on 2022-10-282022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] analysis Analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles [DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article
Renoprotective Effects of Luteolin: Therapeutic Potential for COVID-19-Associated Acute Kidney InjuriesReview Published on 2022-10-232023-07-10 Journal: Biomolecules [Category] COVID19(2023년), [키워드] coronavirus flavonoids medicinal plant natural products nephrotoxicity renal disease renoprotective effect. SARS-CoV-2 [DOI] 10.3390/biom12111544 PMC 바로가기 [Article Type] Review
Evaluation of the effects of chlorhexidine and several flavonoids as antiviral purposes on SARS-CoV-2 main protease: molecular docking, molecular dynamics simulation studiesArticle Published on 2022-10-012023-07-06 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] chlorhexidine flavonoids main protease molecular docking molecular dynamics simulation. SARS-CoV-2 [DOI] 10.1080/07391102.2021.1900919 PMC 바로가기
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus DiseaseArticle Published on 2022-09-272022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] ACE2 Compound coronavirus coronavirus disease Coronaviruses COVID-19 death Diseases drug Drug discovery effective flavonoid flavonoids higher affinity Host in silico in silico studies. in vitro in vivo Infection inhibit Interaction involved lower binding energy M pro mechanism Medicine MPro natural outbreak Potential proliferation Protein recent researcher Ritonavir SARS-CoV-2 silico study Spike protein Structure therapeutic agent these compound Treatment Wuhan, China [DOI] 10.3390/molecules27196374 PMC 바로가기
Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulationsSARS-COV 바이러스에 대한 프로폴리스 효능: 항균 활성 및 분자 시뮬레이션에 대한 검토Review Published on 2022-08-012022-09-11 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 치료제, [키워드] activities activity addition adjuvants Anti-inflammatory Anti-viral antimicrobial Antimicrobial activities appear biological properties combating Comorbidities Compound COVID-19 COVID-19 patient COVID-19 symptoms COVID-19 treatment COVID-19 vaccine discharge Efficacy evaluated flavonoids highlight hospitals immunomodulatory include investigated Molecular simulation molecular simulations mortality rate nutraceutical nutraceuticals patients Pharmacological properties Propolis provide receiving reduce viral replication reduced Research SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2-infected patients Symptom the SARS-CoV-2 virus Treatment vaccine. viral clearance viral replication while [DOI] 10.1007/s11356-022-21652-6 PMC 바로가기 [Article Type] Review
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infectionsSARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases. [DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article
Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compoundsSARS-CoV-2에 대한 벤잘아세토페논 유도체의 잠재적 다중 표적 생리활성 화합물의 전산 조사Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro 3CL(pro) addition Anti-SARS-CoV-2 Activity Antiviral antiviral activities Antiviral agents AutoDock Benzalacetophenones binding affinity binding energy binding free energy biological processes Candidates cellular components Compound COVID-19 derivative develop Diseases domain down-regulated enrichment analysis evaluated FIVE flavonoids free energy highest highest binding affinity identify Immune boost immune system Immunity immunostimulant Interaction lab modulated modulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular functions Molecular mechanics multiple pathway multiple pathways network network pharmacology nine non-infectious Papain Papain-like protease pathway Pathways Patient pharmacological PL(pro) precursor precursors protease Protein recorded reflected regulated retrieved SARS-CoV-2 scored screened Simulation spike Spike protein spike protein. surface area target upregulated was performed [DOI] 10.1016/j.compbiomed.2022.105668 PMC 바로가기 [Article Type] Article
Comparative evaluation of flavonoids reveals the superiority and promising inhibition activity of silibinin against SARS-CoV-2플라보노이드의 비교 평가는 SARS-CoV-2에 대한 silibinin의 우수성과 유망한 억제 활성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] amino acids antiviral activity binding binding affinity Comparative Compound enzyme Enzyme inhibition evaluated exhibited FDA-approved drug flavonoid flavonoids followed by highest highest binding affinity in silico in silico study in vitro in vitro evaluation in vitro study indicated inhibition activity inhibition assay Interaction interfere key amino acid key amino acids M pro mammalian cell mapping molecular docking plant plants protease Protein RdRP Replication reveal S protein Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SARS-CoV-2 S protein Screening selectivity index Serine significantly silibinin silibinin. systematic literature search targets TMPRSS2 transmembrane serine protease virucidal was tested [DOI] 10.1002/ptr.7486 PMC 바로가기 [Article Type] Article