A Chatbot to Support Young People During the COVID-19 Pandemic in New Zealand: Evaluation of the Real-World Rollout of an Open TrialArticle Published on 2022-11-042022-11-15 Journal: Journal of Medical Internet Research [Category] 치료제, [키워드] Adolescent mental health age Anxiety chatbot chatbots cognitive commenced Community connection COVID-19 detect dialog-based intervention digital mental health feasibility feedback flexible help highlight implementation initial iterative lockdown maintain management Mental mental health New online questionnaire open trial Positive psychology Support therapy trial infrastructure Youth [DOI] 10.2196/38743 PMC 바로가기
Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMOArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral drugs atomic binding blind cascade cellular Clustering complex cytotoxicity docking evaluated exhibited flexible FMO inhibitor interact Interaction Ligand M pro mechanism molecular Pathways protease protein-ligand interactions provided residues SARS-CoV-2 SARS-CoV-2 main protease target protein the binding affinity the SARS-CoV-2 [DOI] 10.1038/s41598-022-22703-1 PMC 바로가기
Comparison of SARS-CoV-2 Detection from Saliva Sampling and Oropharyngeal SwabArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome addition analyzed buffer Care clinics Cohort collected Community comparable coronavirus COVID-19 COVID-19 pandemic detection detection rate effective ENhance examined feasible flexible Health Large-scale testing lockdowns Oropharyngeal oropharyngeal swab pandemic performed positive reduce resource reverse transcription-PCR RNA RNA stability RT-PCR RT-qPCR Saliva sampling SARS-CoV-2 SARS-CoV-2 detection Schools screening method sensitivity Sensitivity and specificity specificity stability subject subjects Swab swabbing symptomatic and asymptomatic temperature Viral RNA was used [DOI] 10.1128/spectrum.01422-22 PMC 바로가기
Singleplex, multiplex and pooled sample real-time RT-PCR assays for detection of SARS-CoV-2 in an occupational medicine settingArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 2019-nCoV addition Analysis Asymptomatic CDC clinical sample condition Contact COVID COVID-19 COVID-19 disease Critical defined Detection limit diagnostic diagnostic test disease equipment FDA flexible healthcare high risk implication include Infection limit methodology multiplex overlap pandemic Pandemics Panel Patient Population positive sample progressed reagent real-time RT-PCR resource resources RT-PCR SARS-CoV-2 sensitivity spread of COVID-19 symptomatic Symptomatic patients tested Transmission was determined [DOI] 10.1038/s41598-022-22106-2 PMC 바로가기
Interpreting global variations in the toll of COVID-19: The case for context and nuance in hypothesis generation and testingArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] affecting aggregate aggregates Analysis analyzed benefit Biomarker Biomarkers cause-specific mortality country covariate COVID COVID-19 COVID-19 pandemic database domain domains driver ecological events extension Factor Factors flexible Health health economics Health policy Hypothesis Interaction interactions Interpreting Isolation joint Lifestyle factors machine learning morbidity National obesity OLS omicron outcome outcomes pandemic Policy Population populations potential risk response SARS-CoV-2 socioeconomics statistical statistical methods. These data variant variants Variation while [DOI] 10.3389/fpubh.2022.1010011 PMC 바로가기
Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionalsArticle Published on 2022-10-142022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy analyzed antibodies Antibody Response being Blood blood collection both group capillary capillary blood Clinical practice collected correlation coefficient COVID-19 COVID-19 vaccine criteria determine dose effective evaluate feasibility feasible flexible Health Immune-mediated inflammatory disease less majority NPs participant Patient patient groups professional promoter protocol recorded Remote care reported Safe Saliva SARS-CoV-2 antibody response SARS-CoV-2 vaccines self-collection Self-sampling significantly significantly higher Spearman SUS telehealth Usability vaccination Vaccination strategy Vaccine venous Wilcoxon signed-rank test [DOI] 10.3389/fpubh.2022.994770 PMC 바로가기
Extended compartmental model for modeling COVID-19 epidemic in SloveniaArticle Published on 2022-10-082022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] absence age approach Asymptomatic disease changes in compartmental model COVID-19 epidemic COVID-19 situation epidemiological European expected explained Extended flexible groups heterogeneous Intervention limitation mathematical outbreak parameter predict predicted progression public health SEIR Slovenia symptomatic unvaccinated populations vaccination viral variant [DOI] 10.1038/s41598-022-21612-7 PMC 바로가기
Catching the Wave: Detecting Strain-Specific SARS-CoV-2 Peptides in Clinical Samples Collected during Infection Waves from Diverse Geographical LocationsArticle Published on 2022-10-072022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis antigen detection bioinformatics caused changes in clinical Clinical data clinical samples collected coronavirus Coronavirus disease 2019 COVID-19 demonstrated detect diagnostics flexible Health help Infection location mass-spectrometry pandemic PCR peptide proteome resulting Sample SARS-CoV-2 sequence strain strain-specific Strains utility Vaccine development variant Variant detection Viral protein viral variant Wave [DOI] 10.3390/v14102205 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article