A film-lever actuated switch technology for multifunctional, on-demand, and robust manipulation of liquids Research Published on 2022-08-202022-10-05 Journal: Nature Communications [Category] 치료기술, [키워드] accelerate Analysis applied coefficient Concordance controls diagnostic equipment feature fluorescence intensity function multifunctional Nasal sample offer Patient Pearson platform polymerase chain professional required robust [DOI] 10.1038/s41467-022-32676-4 [Article Type] Research
Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro저분자량 키토올리고당은 시험관 내에서 SARS-CoV-2의 감염을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Analysis Antiviral Antiviral effect antiviral effects candidate chitooligosaccharide chitosan COVID-19 cytotoxicity dose-dependent manner Drug development E gene fluorescence intensity gel in vitro infected cells Infection inhibit low molecular weight molecular weight MTT natural antiviral natural treatment. permeation Plaque assay Protein Quantitative RdRP respond SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Significance suggested tested the SARS-CoV-2 virus Treatment Vero cells Viral RNA virus-infected cell virus-infected cells was measured [DOI] 10.1111/jam.15618 PMC 바로가기 [Article Type] Article
Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLproSARS-CoV-2 Papain-like Protease PLpro용 유전적으로 인코딩된 형광 센서Article Published on 2022-07-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acceptor Biliverdin Cell cleavage co-expression coronavirus COVID-19 detect Donor downstream Endoplasmic reticulum energy transfer enzymatic activity fluorescence intensity fluorescent fluorescent protein FRET genetically encoded probes HeLa cells increase in inhibitors lifecycle linker live cell live cell imaging live cells membrane mNeonGreen non-structural protein non-structural proteins nsp1 NSP2 Nsp3 Papain Papain-like protease PLPro polyprotein protease protease PLpro Protein SARS-CoV-2 SARS-CoV-2 propagation sensor separated Stage the SARS-CoV-2 translocation [DOI] 10.3390/ijms23147826 PMC 바로가기 [Article Type] Article
Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids동시 분광형광법을 사용한 COVID-19 치료를 위한 FDA 승인 약물인 favipiravir 및 hydroxychloroquine의 정량 분석: 제약 제제 및 생물학적 유체에 적용Article Published on 2022-06-012022-09-11 Journal: Luminescence : the journal of biological and chemi [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acetate acute respiratory syndrome Analysis applied approach biological fluid biological fluids buffer cause caused condition contagious coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 country COVID-19 Detection limit diluent drug Drug administration Ethanol exhibited Favipiravir FDA-approved drug fluorescence intensity food harmonization Healthcare systems human plasma sample human plasma samples Hydroxychloroquine identify information Interference International Conference investigated limit limits medications Pharmaceutical Preparation pharmaceutical preparations quantitation SARS-CoV-2 sensitivity Severe acute respiratory syndrome synchronous synchronous fluorimetry. Treatment United State United States United States Food and Drug Administration viral infection were measured [DOI] 10.1002/bio.4240 PMC 바로가기 [Article Type] Article
Fluorescent bioassay for SARS-CoV-2 detection using polypyrene-g-poly(ε-caprolactone) prepared by simultaneous photoinduced step-growth and ring-opening polymerizations동시 광유도 단계 성장 및 개환 중합에 의해 제조된 폴리피렌-g-폴리(ε-카프로락톤)를 사용한 SARS-CoV-2 검출을 위한 형광 생물검정Article Published on 2022-04-262022-09-11 Journal: Mikrochimica Acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis approach calibrated characterized coefficient Coefficient of variation construction demonstrated described Diagnosis feature Fluorescence fluorescence intensity fluorescent Fluorescent biosensor Graft Graft copolymer high correlation immunofluorescence limit of detection Nasopharyngeal samples negative and positive Photopolymerization platform pyrene quantification repeatability reporter reproducibility Ring-opening polymerization RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody Significant significant differences spectral analysis Step-growth polymerization. Variation was tested was used [DOI] 10.1007/s00604-022-05244-2 PMC 바로가기 [Article Type] Article
Capability of novel fluorescence DNA-conjugated CdTe/ZnS quantum dots nanoprobe for COVID-19 sensingCOVID-19 감지를 위한 새로운 형광 DNA 접합 CdTe/ZnS 양자점 나노프로브의 기능Article Published on 2022-03-152022-09-11 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] CdTe/ZnS quantum dots complementary Complementary DNA Concentration conditions conjugate COVID-19 Covide-19 virus DNA energy transfer fluorescence intensity FRET infected patient infected patients linear linear equation mixture Nanosensor Nanosensor. outcome positive control R 2 Regression replacing RNA RT-PCR Saliva thioglycolic acid was determined [DOI] 10.1016/j.saa.2021.120702 PMC 바로가기 [Article Type] Article
Digital Microfluidic qPCR Cartridge for SARS-CoV-2 DetectionArticle Published on 2022-01-272022-10-30 Journal: Micromachines [Category] COVID-19, [키워드] cartridge Contact tracing Control coronavirus disease COVID-19 Critical detect detection develop Digital digital microfluidics droplet qPCR Efficiency electrowetting fluorescence intensity health monitoring high accuracy N gene N1 and N2 pandemic parameter POC polymerase chain primer-probe set produced qPCR Quantitative reduction SARS-CoV-2 target region temperature the SARS-CoV-2 Transmission Volume [DOI] 10.3390/mi13020196 PMC 바로가기 [Article Type] Article
Response to Vaccination Against SARS-CoV-2 in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Renal InvolvementMedicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] affected Against age ANCA-associated vasculitis antibody Blood blood sample booster vaccination cohort of patient collected data COVID-19 COVID-19 vaccination COVID-19 vaccine cytoplasmic disease dose doses evaluated Evidence females first dose fluorescence intensity high risk hospital Immunosuppression Involvement IQR Local median National offer Patient Patient care patient cohorts Pfizer public health reduced regimen renal renal disease renal impairment Renal involvement response response to vaccination Result retrospective risk of COVID-19 rituximab SARS-CoV-2 second dose Seroconversion seroconversion response seroconvert subgroup analysis Support treated Treatment vaccination Vaccine was measured [DOI] 10.3389/fmed.2021.817845 PMC 바로가기 [Article Type] Medicine
Quantitation of Trastuzumab and an Antibody to SARS-CoV-2 in Minutes Using Affinity Membranes in 96-Well Plates96웰 플레이트에서 친화성 막을 사용하여 몇 분 안에 SARS-CoV-2에 대한 Trastuzumab 및 항체 정량화Article Published on 2022-01-182022-09-12 Journal: Analytical Chemistry [Category] SARS, 진단, [키워드] 96-well plate Activation affinity Analysis average binding calibration curve Combination concentrations effective fluorescence intensity group human serum mAb mAbs membrane membranes microplate reader minute monoclonal antibody occur passage Patient peptide Plate Protein quantitation Research SARS-CoV-2 secondary antibody serum Spike protein the SARS-CoV-2 therapeutic Trastuzumab Treatment Variability [DOI] 10.1021/acs.analchem.1c03654 PMC 바로가기 [Article Type] Article
High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 PatientsArticle Published on 2021-12-182022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] analyzed B-cell Biomarker Blood blood cell blood sample CD169 CD8 T-cell clinical outcomes correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 therapy cytokine Cytokine storm disease Disease progression Disruption dose-dependent manner Evidence flow cytometry fluorescence intensity healthy donor Hospitalization IL-10 IL-6 immune dysfunction immunophenotype in vitro Inflammation inflammatory markers lymphocyte marker maturation monocyte mRNA expression mRNA levels outcome overexpressed Patient PBMC Pneumonia Predictive pulmonary involvement Ratio Respiratory outcome SARS-CoV-2 severity sialoadhesin stimulated T-cell exhaustion the median the spike protein Transcription [DOI] 10.3390/pathogens10121639 PMC 바로가기 [Article Type] Article