Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock-a two-centre randomised clinical trialRandomized Controlled Trial Published on 2022-09-052022-10-05 Journal: Critical Care [Category] 임상, [키워드] Acute kidney injury Adequate Adult patient antibiotic Antibiotics clinical Clinical decision support clinical trial control group COVID-19 pandemic Critically ill patient critically ill patients data-driven dose Efficacy eligible Endpoint EudraCT European evaluate faster feasibility feasible for inclusion ICU implementation IMPROVE incidence Inclusion increased mortality Infection intervention group Lactate Mortality Netherland not significantly different outcome patients personalised pharmacokinetic pharmacokinetics Primary outcome randomisation randomised Registered renal right Safe Sepsis Septic shock significantly Support Therapeutic Drug Monitoring Trial was obtained [DOI] 10.1186/s13054-022-04098-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Immunogenicity and reactogenicity of an inactivated SARS-CoV-2 vaccine (BBV152) in children aged 2-18 years: interim data from an open-label, non-randomised, age de-escalation phase 2/3 studyClinical Trial Published on 2022-09-012022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% CI Administered Adults adverse event age all age group antibody baseline Bharat Biodefense children clinical conducted COVID-19 vaccine curtail deaths decrease demonstrated dose Efficacy eight eligible Endpoint enrolled female Fever for inclusion geometric mean GMT ratio GMTs group groups healthy children hospital Hyderabad immunogenicity immunosuppressive inactivated Inactivated vaccine India Infection injection site pain intramuscular dose less Local local reaction male Mild Mild-to-moderate multicentre neutralisation test neutralising antibody response neutralising antibody titre no difference Open-label Pain pandemic participant Phase 2 study phase 2/3 platform positive PRNT Reactions reactogenicity reduction Registered registry reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 vaccine second dose Serious Adverse Events seroconverted serology test serum sample severity of COVID-19 susceptible Symptom three group titre Trial were excluded Withdrawal [DOI] 10.1016/S1473-3099(22)00307-3 PMC 바로가기 [Article Type] Clinical Trial
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Artificial intelligence model on chest imaging to diagnose COVID-19 and other pneumonias: A systematic review and meta-analysisReview article Published on 2022-08-182022-10-05 Journal: European Journal of Radiology Open [Category] 진단, [키워드] 2Dtwo-dimensional 3Dthree-dimensional 95 % CI Accuracy AIartificial intelligence area under the curve article artificial intelligence AUC AUCarea under the curve average C-reactive protein calculate Characteristics chest imaging chest X-ray CNNConvolutional neural network Cochrane Library Computed tomography Convolutional neural network Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 COVID‐19 CRPC-reactive protein CTComputed Tomography CXRChest X-Ray Deep Learning Method diagnose diagnosing diagnostic disease for inclusion Future Generalizability GGOground-glass opacities Ground-glass opacities heterogeneity IMPROVE K-nearest neighbor KNNK-nearest neighbor LASSOleast absolute shrinkage and selection operator least absolute shrinkage and selection operator less machine learning MEERS-COVMiddle East respiratory syndrome coronavirus Meta-analysis Methodological quality methodology Middle East respiratory syndrome Coronavirus MLmachine learning negative likelihood ratio objective participant performed PLRnegative likelihood ratio PLRpositive likelihood ratio Pneumonia positive likelihood ratio predictive models QUADAS-2 Quality radiologist random-effects model regions of interest Research researcher Result retrieved Reverse transcriptase polymerase chain reaction ROIregions of interest RT-PCRReverse transcriptase polymerase chain reaction SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome score screened searched sensitivity Sensitivity and specificity Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 specificity SROCsummary receiver operating characteristic summary receiver operating characteristic support vector machine SVMSupport vector machine systematic review three-dimensional total score two-dimensional Web of Science were used [DOI] 10.1016/j.ejro.2022.100438 [Article Type] Review article
Improving child health through Big Data and data science Reviews Published on 2022-08-162022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] assessments Characteristics child health childhood children complex creating defined determinant developmental dimension disease risk Diseases fetal for inclusion Genetic Health highlight identify Impact IMPROVE Improving infancy Interaction mechanisms outcomes Patient pediatric phenotype Predictive provide Racial recommendation reducing Regulatory Research resource susceptibility the United State Therapies Trajectories while [DOI] 10.1038/s41390-022-02264-9 [Article Type] Reviews
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope우성 SARS-CoV-2 킬러 T 세포 에피토프에서 면역 탈출의 출현Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen CD8 CD8 T cell Cohort cohorts convalescent patient Convalescent patients coronavirus COVID-19 dominant emergence epitope Epitopes for inclusion Frequency glycoprotein highlighting HLA human leukocyte antigen immune Immune escape individual leukocyte Lineage lineages mounted Mutation new SARS-CoV-2 Next generation vaccine next generation vaccines peptide-HLA Phylogenetic prevalent Protein response SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 spike SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus spike spike glycoprotein T cell T cell epitope T cell epitopes T cell receptors vaccine immunity variants viral escape Viral protein Viral proteins [DOI] 10.1016/j.cell.2022.07.002 PMC 바로가기 [Article Type] Article
Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: A systematic review최근 또는 현재 SARS-CoV-2 감염이 있는 기증자의 고형 장기 이식: 체계적인 검토Review Published on 2022-08-012022-09-11 Journal: Anaesthesia, critical care & pain medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] anti-SARS-CoV-2 titer Cochrane COVID-19 Study Register complications COVID-19 COVID-19 symptoms cycle database died Donor donors dysfunction evaluate for inclusion heart Hospital stay IQR kidney kidneys liver lung median Mortality occurred organ Organ donation organ transplantation organs outcome Patient patients died positive recipient recipients rejection risk of transmission Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral Septic shock solid organ solid organ transplantation SOT Symptom symptomatic systematic review threshold Transmission Transplant two patients viral replication Viral transmission was performed Web of Science [DOI] 10.1016/j.accpm.2022.101098 PMC 바로가기 [Article Type] Review
Consensus recommendations for opioid agonist treatment following the introduction of emergency clinical guidelines in Ireland during the COVID-19 pandemic: A national Delphi studyResearch article Published on 2022-08-012022-10-05 Journal: The International Journal on Drug Policy [Category] 치료법, [키워드] Addiction services Care change clinical clinical guideline Clinical guidelines Community Consensus COVID-19 DelPhi Delphi technique develop domains dosage doses drug policy Emergency Final for inclusion Frequency Guidance guideline harm reduction Health identify include introduced involved Ireland lower quartile maintenance phase median methodology National OAT Opioid agonist treatment over pandemic practitioners promote provided psychiatrists reached recommendation recruited Result resulting retained risk Safe Substance use disorder Treatment Urine [DOI] 10.1016/j.drugpo.2022.103768 [Article Type] Research article
COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review사후 평가에서 COVID-19-관련 심장 병리: 공동 체계적 검토Review Published on 2022-08-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] article Autopsy autopsy studies biases cardiac Cardiac pathology cardiovascular complication cardiovascular complications change Cohort Cold Confirmed confirmed COVID-19 patients coronavirus COVID-19 COVID-19 patient database Deceased EBM Effect eligibility eligible fibrosis for inclusion Harbor hearts Histopathology hypertrophy individual Infection information interquartile range IQR IQRs manuscript median median age Myocardial myocardial necrosis myocarditis Myocardium oedema OVID Patient Post-mortem Postmortem Prevalence prevalent reported risk SARS Coronavirus SARS-CoV-2 searched small sample size spring systematic review Web of Science with COVID-19 [DOI] 10.1016/j.cmi.2022.03.021 PMC 바로가기 [Article Type] Review
Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis사망 예방을 위한 SARS-CoV-2 백신의 효능 및 효과: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] adverse event all-cause mortality analyzed approved assessment Bia calculated case-control studies case-control study Cohort controlled trials COVID-19 death deaths effective Effectiveness Efficacy Egger eligible Evidence exploratory for inclusion forest plot forest plots funnel plot hazard hazard ratios heterogeneity Hospitalization incident independent intervals Intervention Meta-analysis Mortality Observational data outcome Placebo Prevent Primary outcome PROSPERO protocol Publication bia publication bias randomized control trial Randomized controlled trials RCT Record reducing Registered risk reduction SARS-CoV-2 vaccine SARS-CoV-2 vaccines Secondary outcomes Severe case severe cases statistical statistical test systematic review the vaccine the vaccines university vaccination Vaccination Status Vaccine visual inspection York [DOI] 10.1371/journal.pone.0265414 PMC 바로가기 [Article Type] Article