Phylodynamics of a regional SARS-CoV-2 rapid spreading event in Colorado in late 2020Article Published on 2022-10-042022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Academy Aurora collected Community Course Divergence estimate Evolution force genomic initial Lineage Local outbreak Phylogenetic protocol rapid expansion replicate reported SARS-CoV-2 SARS-CoV-2 genome Sequencing spring Surveillance the SARS-CoV-2 the United State Transmission Transmission dynamics transmission pathway university variant Variation [DOI] 10.1371/journal.pone.0274050 PMC 바로가기
Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI)전기화학적 면역센서(GDEI)에 증착된 금 나노막대를 제작하여 SARS CoV-2 수용체 결합 도메인(RBD) 단백질의 무표지 검출Article Published on 2022-09-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] AFM antibody binding Blot chain Chain Reaction characterized cloned collected coronavirus disease Coronavirus disease 2019 COVID-19 Cross reactivity cyclic Detection limit DPV dynamic early diagnosis Efficiency electrochemical electron electron carrier Electrophoresis ELISA enzyme enzyme-linked immunosorbent assay expressed fabrication flight fluorine followed by force FTO gel electrophoresis gold Gold nanorods house immobilization Infectious disease kDa lAbel Laser LIGHT MERS middle Middle East Middle East respiratory syndrome molecular weight nasopharyngeal sample Outbreaks output Oxide pandemic polyacrylamide Population Protein RBD RBD antigen RBD gene reaction Receptor binding domain respiratory reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS CoV SARS CoV-2 SDS-PAGE shown Spectroscopy spike Spike protein stability TEM tested the patient Tin Tin Oxide transmission electron microscopy viral transport media VTM was determined western blot [DOI] 10.1016/j.bios.2022.114406 PMC 바로가기 [Article Type] Article
U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task ForceResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 바이오마커, 유전자 메커니즘, [키워드] addition Admission association body mass index Clinical characteristics co-morbidities Cohort COVID-19 COVID-19 severity enrolled force High serum uric acid Hyperuricemia Hypouricemia identify IMV increased risk Invasive mechanical ventilation Japan Japanese Laboratory Logistic regression analysis Low serum uric acid objective Odds ratio Older outcomes Patient Respiratory care Result serum severity significantly uric acid with COVID-19 [DOI] 10.1016/j.ijid.2022.07.014 [Article Type] Research article
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)Research article Published on 2022-08-262022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Administered Adults aerobic age asymptomatic infection base Blood BMI cardiovascular complications cholesterol cohort study Concentration control group COVID-19 COVID-19 group criteria defined Diagnosis diagnostic dyslipidaemia enrolled fatigue Fatigue scale female finding Follow-up force funding Health healthy higher risk individual Intensive IQR Laboratory Laboratory parameters LDL longitudinal cohort study male management median men metabolic disorder negative RT-PCR neurological no symptoms non-hospitalised organ systems outcomes participant Participants persistent physical polymorphism positive positive PCR test presenting Prevalence Psychological public health quantified questionnaire Registered renal reported reproductive RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serologically serologically positive significant difference study groups Switzerland Symptom the median threshold were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00449-2 [Article Type] Research article
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force일본 COVID-19 태스크포스의 465개 COVID-19 감염 샘플의 전혈 전사 조절 풍경Article Published on 2022-08-222022-09-11 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] Analysis caused CLEC4C coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 infected individual COVID-19 infection COVID-19 phenotype COVID-19 severity deaths Differential gene expression differential gene expression analysis disease eQTL eQTLs evaluate example expression expression quantitative trait loci force functions Gene Expression genotyped highlight increased expression independent Infectious disease Japan Japanese loci mechanism MYBL2 phenotype provide QTL Quantitative Regulation Regulatory REST RNA-seq data severe COVID-19 single variant splice STING1 Task Force TOR1AIP1 transcriptional transcriptional regulation variant Whole blood [DOI] 10.1038/s41467-022-32276-2 PMC 바로가기 [Article Type] Article
Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics Research Published on 2022-08-092022-10-05 Journal: Nutrition & Diabetes [Category] SARS, 바이오마커, 유전자 메커니즘, 치료법, [키워드] adjusted adjusted odds ratio Analysis analyzed benefit BMI body mass index class coronavirus disease COVID-19 COVID-19 patient Critical Critical case critical cases defined died disease severity Effect enrolled force host genetics independent risk factor indicated intensive care Invasive mechanical ventilation Japan Japanese Mild mortality rate multiple logistic regression no difference obesity Odds ratio outcome Oxygen administration Oxygenation Patient patients with COVID-19 reported required Respiratory failure Result risk risk factor severe COVID-19 severe disease severity of COVID-19 stratified the patient treated [DOI] 10.1038/s41387-022-00217-z [Article Type] Research
Interactions listed in the Paxlovid fact sheet, classified according to risks, pharmacological groups, and consequences위험, 약리학 그룹 및 결과에 따라 분류된 Paxlovid 팩트 시트에 나열된 상호 작용Article Published on 2022-08-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered Antiviral consequence COVID-19 CYP3A4 drug Drug interactions ELLA English force groups inhibitor Isoenzyme low dose medication Medicine Medicines metabolism Nirmatrelvir oxidative Paxlovid pharmacological Precaution precautions Prophylaxis protease responsible Ritonavir SARS-CoV-2 SARS-CoV-2 main protease Spanish therapeutic therapeutic effect Treatment [DOI] 10.37201/req/054.2022 PMC 바로가기 [Article Type] Article
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trialChAdOx1 nCoV-19 또는 BNT162b2 2회 접종 및 BNT162b2(COV-BOOST) 3차 접종 후 4차 접종으로 제공된 BNT162b2 및 mRNA-1273 COVID-19 백신의 안전성, 면역원성 및 반응성: 다기관, 맹검, 단계 2, 무작위 시험Clinical Trial Published on 2022-08-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 95% CI adverse event All participants analysed anti-spike protein IgG assigned blinded block size BNT162b2 boost booster Booster vaccine cellular Cellular and humoral immunity Cellular immune response ChAdOx1 nCoV-19 computer-generated Concentration Controlled trial country COV-BOOST COVID-19 COVID-19 vaccine COVID-19 vaccines dose doses Effectiveness ELISA ELISPOT Endpoint enrolled fatigue female Fold change Fold changes force geometric geometric mean groups Humoral immunity immunogenicity Intramuscular injection IQR ISRCTN Laboratory Local male median age median interval Moderna modified intention-to-treat mRNA mRNA-1273 mRNA-1273 booster mRNA-1273 COVID-19 vaccine multicentre of BNT162b2 outcome participant peak per-protocol population Pfizer-BioNTech Phase 2 random randomisation list randomised controlled trial Randomised trial Randomly reactogenicity receive Registered reported representing response Safety SARS-CoV-2 screened Serious Adverse Event seronegative participant seronegative participants serostatus Seven significant increase statistician T-cell Response T-cell responses Task Force the vaccine the vaccines titre treatment allocation Trial upper arm Vaccine variant were assessed wild-type [DOI] 10.1016/S1473-3099(22)00271-7 PMC 바로가기 [Article Type] Clinical Trial
Asia Pacific perspectives on the second year of the COVID-19 pandemic: A follow-up surveyCOVID-19 대유행 2년차에 대한 아시아 태평양 전망: 후속 조사Article Published on 2022-08-012022-09-12 Journal: Clinical and experimental allergy : journal of the [Category] Coronavirus, 진단, [키워드] Adverse reaction anaphylaxis Anti-viral anticipated Asia Baricitinib Care changes in cilgavimab clinical complement contributed Coronavirus disease 2019 country COVID-19 COVID-19 disease COVID-19 vaccination programme Dexamethasone Endemic endemic diseases Epidemiology Follow-up force incidence males mild-to-moderate disease morbidity and mortality mRNA neutralizing antibody novel Pacific Association pandemic Perspective preventive measures Prophylaxis public health public health measure question Remdesivir response Ritonavir severe disease Severe infection survey Therapeutics Tixagevimab vaccination Vaccine [DOI] 10.1111/cea.14191 PMC 바로가기 [Article Type] Article
Repurposing Positive SARS-CoV-2 Antigen Test Devices for Variant Tracking변이 추적을 위한 양성 SARS-CoV-2 항원 테스트 장치 용도 변경Article Published on 2022-07-262022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analysed Antigen antigen tests appearance circulating variant circulating variants Community determine Device diagnosed expand expansion force Healthcare systems include nasopharyngeal swabs new SARS-CoV-2 pandemic positive positive sample processed protocol repurposing RT-PCR SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variants statistically significant Taking Test the patient the SARS-CoV-2 to be done variant variants virus [DOI] 10.1007/s00284-022-02973-8 PMC 바로가기 [Article Type] Article