four group – Communicable Diseases Research

Association of trace element status in COVID-19 patients with disease severity

Research article

Published on 2022-12-012022-10-05
Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 변종,

Characterization of compliance phenotypes in COVID-19 acute respiratory distress syndrome

Observational Study

Published on 2022-08-012022-10-05
Journal: BMC Pulmonary Medicine [Category] 임상,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ARDS association characterization Cohort collected Compliance compliant lungs coronavirus COVID-19 COVID-19 disease criteria dependent on diagnosis of COVID-19 disease distress driving End-Expiratory Pressure enrolled evaluated Evolution four group greater group groups Hypothesis Hypoxemia ICU ICUs identify IMPROVE initial intensive care lower quartile lung Lung compliance mechanically ventilated patient median Oxygenation PaO parameter Patient patients with COVID-19 PEEP phenotype preserved prone prone positioning prospective observational study quartile relationship respiratory Respiratory mechanics Respiratory system SARS Coronavirus significantly single-center static compliance syndrome tested the disease
[DOI] 10.1186/s12890-022-02087-8 PMC 바로가기 [Article Type] Observational Study

The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial study

Randomized Controlled Trial

Published on 2022-07-292022-10-05
Journal: Medicine [Category] COVID19(2023년), SARS, 임상,

[Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases]

[소아 오미크론 변이체 감염 회복기 혈청 IgG 항체 변화 : 110건 분석]

Article

Published on 2022-07-152022-09-11
Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis antibody BBIBP-CorV Beijing Biological Biological products booster vaccination caused Child children China Chinese citation Clinical data Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Diagnosis disease dose doses English four group four groups groups IgG IgG antibody inactivated Inactivated vaccine Infection journal no significant difference no significant differences Nucleic acid detection omicron pediatrics protective effect RBD IgG Recovery stage reduction in respiratory Retrospective analysis route SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 nucleic acid SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum IgG Serum level severe acute respiratory syndrome Coronavirus Sex significant difference significant differences significantly higher significantly lower Sinopharm status the vaccine Tianjin Transmission two group two groups vaccination Vaccine variant was performed
[DOI] 10.7499/j.issn.1008-8830.2204074 PMC 바로가기 [Article Type] Article

Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial

6~17세 어린이 대상 ChAdOx1 nCoV-19(AZD1222) 백신의 안전성 및 면역원성: 2상 단일 맹검, 무작위, 대조 시험인 COV006의 예비 보고서

Clinical Trial

Published on 2022-06-112022-09-11
Journal: Lancet (London, England) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법,

[키워드] 95% CI administration Adults adverse event adverse events age All participants anti-SARS-CoV-2 IgG antibody Antibody titre antibody titres arbitrary unit assigned AstraZeneca AZD1222 baseline capsular Cellular responses ChAdOx1 ChAdOx1 nCoV-19 children chronic respiratory conditions Concentration Controlled trial COVID-19 COVID-19 vaccine COVID-19 vaccines Cutoff Department dose doses Efficacy enrolled Fever first dose first vaccination four group four groups geometric geometric mean geometric mean ratios Geometric means group half-maximal inhibitory concentration Humoral response humoral responses immune response immune responses immunogenic immunogenicity in some intramuscular dose introduced investigators ISRCTN Laboratory laboratory-confirmed Laboratory-confirmed COVID-19 Local nucleocapsid protein Pain and tenderness participant Participants peaked Phase 2 phase 3 study preliminary report Primary outcome prime and boost raised randomised Randomly receive receiving recruitment Registered remained reported resolved respiratory response Safety safety population SARS-CoV-2 second dose second vaccination secondary outcome Serious Adverse Event Serious Adverse Events seronegative seronegative participant seronegative participants seropositive serostatus single-blind stratified study drug study groups tenderness Tolerability treatment allocation Trial vaccination Vaccine Viral viral particle were recorded
[DOI] 10.1016/S0140-6736(22)00770-X PMC 바로가기 [Article Type] Clinical Trial

Effects of different doses of methylprednisolone on clinical outcomes in patients with severe community-acquired pneumonia: a study protocol for a randomized controlled trial

중증 지역사회획득 폐렴 환자의 임상 결과에 대한 다양한 용량의 메틸프레드니솔론 효과: 무작위 대조 시험을 위한 연구 프로토콜

Article

Published on 2022-05-212022-09-11
Journal: Trials [Category] COVID19(2023년), SARS, 임상,

[키워드] 28-day mortality Chinese clinical Clinical efficacy Clinical outcome clinician community-acquired pneumonia complications Consensus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment determine diagnosed different dose different doses dose dose-dependent double-blind Effect Efficacy Efficacy and safety Endotracheal intubation evaluate Final four group Frequency gastrointestinal hemorrhage glucocorticoid help Hospital stay hyperglycemia ICU interleukin interleukin-6 mechanical ventilation duration Methylprednisolone normal saline Nosocomial infections optimal dose PaO parallel group Patient Placebo placebo-controlled trial Primary outcome protocol randomization Randomized Randomized controlled trial registry SCAP secondary outcome Secondary outcomes serum CRP Severe community-acquired pneumonia. Study protocol temperature treat Treatment Vasopressor vasopressors ventilator-free day Volume
[DOI] 10.1186/s13063-022-06404-8 PMC 바로가기 [Article Type] Article

Possible therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19: A pilot randomized, double-blind, clinical trial

Research article

Published on 2022-05-012022-10-05
Journal: Journal of trace elements in medicine and biology [Category] 임상,

[키워드] biochemical parameter Boron Boron citrate clinical trial Combination Concentration concentrations cough COVID-19 COVID-19 patients diagnosis of COVID-19 double-blind erythrocyte sedimentation rate fatigue four group group groups hemoglobin High-sensitivity C-reactive protein IMPROVE interleukin-1β Lymphocyte count medications myalgia O2 Saturation Oleoylethanolamide Patient patients with COVID-19 Placebo Platelet post-intervention PPAR-α Randomized recruited reduction in respiratory rate Result SARS-CoV-2 serum interleukin-6 levels serum lactate Shortness of breath significant decrease significant difference significant increases in significantly symptoms of COVID-19 therapeutic effect Therapies Treatment were assessed White blood cell
[DOI] 10.1016/j.jtemb.2022.126945 [Article Type] Research article

Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months

6개월 후 백신 단독 또는 SARS-CoV-2 감염 + 백신(하이브리드 면역)에 의해 유도된 항체에 의한 오미크론(B.1.1.529) 변이체의 차선 중화

Article

Published on 2022-04-012022-09-11
Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종,

[키워드] 95% CI Against Anti-RBD IgG antibody B.1.1.529 BBV152 Biotechnology ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine correlation Covaxin Covishield cross-sectional cross-sectional study demonstrated Department exhibited explain foundation four group four groups geometric mean geometric mean titre GMT group groups hybrid Hybrid immunity Immune escape Immunity inactivated India individual Infection limit Live virus Live-virus neutralisation Melinda Gate Melinda Gates moderate natural infection nCoV neutralisation neutralisation assay neutralisation test neutralisation titre Neutralisation titres neutralise neutralising ability omicron Omicron variant outcome Primary outcome quantification Rapid reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant serum Significant Spread subjects tested titre USA vaccinated individual vaccinated individuals vaccination Vaccine variant virus Virus neutralisation
[DOI] 10.1016/j.ebiom.2022.103938 PMC 바로가기 [Article Type] Article

Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit

Article

Published on 2022-03-072022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Does quality assured eLearning provide adequate preparation for robotic surgical skills; a prospective, randomized and multi-center study

Randomized Controlled Trial

Published on 2022-03-012022-10-05
Journal: International Journal of Computer Assisted Radiolo [Category] SARS, 임상,

[키워드] Academy approach Complete conducted Course COVID-19 pandemic Critical defined demonstrated effective eLearning. four group individual manuscript methodology Metrics Participants PBP peer-reviewed Primary outcome Proficiency-based progression progression Quality Randomized ranged surgeon surgical surgical training
[DOI] 10.1007/s11548-021-02545-4 PMC 바로가기 [Article Type] Randomized Controlled Trial