Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19코로나19 극복을 위한 포크헤드 박스 O의 치료 가능성 탐색Review Published on 2021-06-092022-09-10 Journal: Open Biology [Category] MERS, SARS, 바이오마커, 신약개발, [키워드] Activation acute respiratory distress alleviate Anti-inflammatory Antiviral Apoptosis approach B lymphocytes cell physiology Clinical management complications coronavirus COVID-19 COVID-19 pandemic cytokine Cytokine storm Cytokines damaged tissue deregulated distress Efficacy FoxO highlight homeostasis immune response infected individual infected individuals Inflammation Inflammatory Inflammatory cytokines lymphocyte Lymphocytes maturation Memory cells Mild multi-organ failure Novel coronavirus oxidative stress pandemic Patient repair reported repurposing respiratory distress SARS-CoV-2 SARS-COV-2 infection secretion severe symptoms survival T and B lymphocytes therapeutic potential transcription factor transcription factors [DOI] 10.1098/rsob.210069 PMC 바로가기 [Article Type] Review
Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugsSARS-CoV-2에 대한 네트워크 분석 및 분자 매핑을 통해 약물 표적을 밝히고 임상적으로 개발된 약물의 용도 변경Article Published on 2021-03-012022-08-31 Journal: Virology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] (hydroxychloroquine) Analysis Antibiotics antimalarial antiretroviral Azithromycin BCL-2 biological process carried chemokine Chemokine receptor clinically Combination coronavirus dietary supplement dietary supplements disease networks docking docking analysis docking study drug drug combination Drug repurposing drug target effective EGFR ErbB Estrogen event FoxO global pandemic GnRH HIF-1 host inflammatory response Hydroxychloroquine IL-17 insulin Interaction involved Jak-STAT KEGG pathway analysis life cycle Lopinavir LOPINAVIR AND RITONAVIR MAPK modulation molecular molecular docking molecular mechanism morbidity and mortality mortality rate multiple pathway multiple pathways network Neurotrophin novel Novel coronavirus Ontology PARP pathway platelet activation predict PRKCB Process analysis receptor reduce Ritonavir SARS-CoV-2 SARS–CoV–2. signaling pathway STAT suggested target targets thyroid hormone TNF Toll-like receptor Treatment VEGF Viral viral infection viral infectivity viral life cycle viral replication virus Vitamin Vitamin C [DOI] 10.1016/j.virol.2020.12.006 PMC 바로가기 [Article Type] Article
Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating FactorsReview Published on 2020-06-102022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] accompanied activated Activation adopted Affect AMPK B cells Biomarker Cancer cardiovascular disease change chronic Chronic low-grade inflammation Combination Community complex Context COVID-19 COX2 demonstrated diabetes diet dietary dietary habit Diseases dose driven by Epidemics Factor fasting fatty acids fiber FoxO Health healthcare help hospitals Human IKK IMPROVE individual individual level Inflammation Inflammatory intervention study IκB MAPK marker Metabolic diseases metabolic disorder MMP9 modulate molecular molecular mechanism Multiple neurodegenerative Nrf2 nuclear pathway Patient polyphenols Polyunsaturated protein kinases public health real-life risk simulation reduced reducing Resilience risk School significantly STAT3 Transcription [DOI] 10.3390/ijerph17114135 PMC 바로가기 [Article Type] Review
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
Involvement of FOXO Transcription Factors, TRAIL-FasL/Fas, and Sirtuin Proteins Family in Canine Coronavirus Type II-Induced ApoptosisResearch Article Published on 2011-11-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activate Activation addition Analysis Blot canine cell death cell line cells coronavirus cytosol decrease demonstrated Effect expression extrinsic extrinsic apoptosis family found FoxO FOXO1 In vitro infection increase in induce Infection intrinsic apoptotic pathway investigated involved Involvement Ligand mitochondrial nuclear pathway post infection pro-apoptotic Protein protein expression Proteins regulate shown significantly SIRT1 SIRT3 SIRT4 sirtuin TRAIL transcription factor translocation Type virus infection [DOI] 10.1371/journal.pone.0027313 PMC 바로가기 [Article Type] Research Article