Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern우려되는 모든 SARS-CoV-2 변이체의 유연한 검출을 위한 다중 단편 분석Article Published on 2022-07-272022-09-11 Journal: Clinical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] ABI Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus allele Analysis analyzed approach capillary electrophoresis concern coronavirus cycle threshold deleted Deletion Delta detection effective equipment exhibited fluorescent fragment insertion insertions Lambda limit of detection multiplex mutants omicron ORF1a ORF8 PCR performed primer primer pair primer pairs RDR RDR1 RDR2 RDR3 Receptor binding domain resolved respiratory specimens S-gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity subsequent target variant variants variants of concern VoC VOCs WGS whole genome Whole genome sequencing [DOI] 10.1093/clinchem/hvac081 PMC 바로가기 [Article Type] Article
Concordance of SARS-CoV-2 RNA in Aerosols From a Nurses Station and in Nurses and Patients During a Hospital Ward Outbreak병원 병동 발병 중 간호사 스테이션과 간호사 및 환자의 에어로졸에서 SARS-CoV-2 RNA의 일치Article Published on 2022-06-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 치료기술, [키워드] aerosol Aerosols Affair Care Chain Reaction cohort study collected Concordance conducted Contact tracing contributed COVID-19 COVID-19 outbreak Department detect finding fraction fragment genome sequence genomic genomic sequence Health Health care Health care system hospital Hospital wards masking nosocomial Nosocomial outbreaks Nurse outbreak outcome Particle Patient polymerase chain reaction positive positive RT-PCR Primary outcome reduce reducing representing reverse transcriptase reverse transcriptase-polymerase chain reaction risk RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sequence identity sequenced similarity Station Surveillance Transmission Ventilation veteran ward were used [DOI] 10.1001/jamanetworkopen.2022.16176 PMC 바로가기 [Article Type] Article
CRISPR/Cas12a-Based Diagnostic Platform Accurately Detects Nocardia farcinica Targeting a Novel Species-Specific GeneCRISPR/Cas12a 기반 진단 플랫폼, 새로운 종 특이적 유전자를 표적으로 하는 Nocardia farcinica를 정확하게 검출Article Published on 2022-05-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] 치료제, [키워드] accurate diagnosis applied Cas12a caused conserved COVID-19 pandemic CRISPR CRISPR-CLA cross-reaction detect detection system diagnose DNA DNA extraction Fluorescence fragment fragment of gold gold standard Infection Infectious disease isothermal amplification LAMP lateral flow limit of detection linker Loop-mediated isothermal amplification media meet Molecular diagnosis MONITOR Nocardia Nocardia farcinica nocardiosis novel nucleic acid Nucleic acid detection PAM pandemic pbr1. platform primer principle probe protospacer adjacent motif reaction real-time qPCR reference strain reported RNA screened sequence single-strand DNA specificity specimen sputum ssDNA strain target targeting tested Validity was used were used [DOI] 10.3389/fcimb.2022.884411 PMC 바로가기 [Article Type] Article
Crystal-structures-guided design of fragment-based drugs for inhibiting the main protease of SARS-CoV-2SARS-CoV-2의 주요 단백질 분해효소를 억제하기 위한 단편 기반 약물의 결정 구조 유도 설계Article Published on 2022-05-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 치료제, [키워드] active site approved binding free energy caused comparable contagious COVID-19 COVID-19 pandemic cure derivative drug drug candidate drug design Drug discovery FDA fragment fragment-based drug design free energy globe infected patients Infectious disease inhibiting Ligand main protease molecular docking molecular dynamics Molecular dynamics simulation MPro principle processed protease Protein resolved SARS-CoV-2 SARS-CoV-2 virus the SARS-CoV-2 virus treat [DOI] 10.1002/prot.26260 PMC 바로가기 [Article Type] Article
SARS-CoV-2 detection using quantum dot fluorescence immunochromatography combined with isothermal amplification and CRISPR/Cas13a등온 증폭 및 CRISPR/Cas13a와 결합된 양자점 형광 면역 크로마토그래피를 사용한 SARS-CoV-2 검출Article Published on 2022-04-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] anal swabs Analysis can not Chromatography cleavage clinical sample clinical samples Combination CRISPR CRISPR/Cas13a diagnosis of COVID-19 equipment fluorescent fragment fragment of gene encoding immunochromatographic immunochromatography isothermal amplification New coronavirus outbreak pandemic point-of-care positive probe Quantum dot Quantum dot fluorescence immune-chromatography resources reverse transcription S protein SARS-CoV-2 SARS-CoV-2 detection Sensitivity and specificity sputum the S protein the SARS-CoV-2 throat swabs [DOI] 10.1016/j.bios.2022.113978 PMC 바로가기 [Article Type] Article
Interaction Analysis of the Spike Protein of Delta and Omicron Variants of SARS-CoV-2 with hACE2 and Eight Monoclonal Antibodies Using the Fragment Molecular Orbital Method단편 분자 궤도 방법을 사용한 hACE2 및 8개의 단일클론 항체와 SARS-CoV-2의 델타 및 오미크론 변이체의 스파이크 단백질 상호작용 분석Article Published on 2022-04-112022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin binding binding affinities binding affinity changed changes in coronavirus crystal structure Delta eight enzyme fragment hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction molecular monoclonal antibodies monoclonal antibody mutated Mutation omicron Omicron variant performed predict predicted Protein Quantum mechanics required residue respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein statistical analysis the binding affinity the Spike the spike protein variant variant of SARS-CoV-2 Viral viral surface [DOI] 10.1021/acs.jcim.2c00100 PMC 바로가기 [Article Type] Article
Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)Review article Published on 2022-01-262022-10-05 Journal: Organic & Biomolecular Chemistry [Category] 치료제, [키워드] active against antiviral drug approach biological activities Compound COVID-19 derivative fragment information Riamilovir SARS-CoV-2 Structure synthetic [DOI] 10.1039/d1ob02125g [Article Type] Review article
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune ResponseCOVID-19 환자의 혈장에서 회수된 엑소좀은 SARS-CoV-2 스파이크 유래 단편을 노출시키고 적응 면역 반응에 기여합니다Immunology Published on 2022-01-172022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute phase acute respiratory syndrome antigen-presenting cells (APCs) beta-coronavirus caused CD4 chronic inflammation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients Exosome Exosomes Extracellular extracellular vesicle fragment globe immune activation immune response immune system immunomodulatory molecules Infectious disease Patient performed plasma Protein proteome recovered reflect response SARS-CoV-2 soluble mediators in immunity spike-derived peptide Spread T-cell responses the disease vector Vesicle viral infection [DOI] 10.3389/fimmu.2021.785941 PMC 바로가기 [Article Type] Immunology
Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 FragmentResearch Article Published on 2022-01-112022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Amino acid cleave cleaved coronavirus CoV CoV infection CoVs Critical epidemic diarrhea Evidence facilitate fragment gasdermin D GSDMD hepatic disease humans Infection inhibit initial MERS-CoV molecular mechanism nsp5 pathway PEDV protease pyroptosis Regulation Replication RNA virus SARS-CoV-2 viral replication virus [DOI] 10.1128/mbio.02739-21 PMC 바로가기 [Article Type] Research Article