Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
Cognitive phenotyping of post-infectious SARS-CoV-2 patients감염 후 SARS-CoV-2 환자의 인지 표현형Article Published on 2022-08-012022-09-11 Journal: Neurological Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Assessing orientation assessment battery both groups clinically cognitive Cognitive impairment Cognitive impairment: executive functioning confounder COVID-19 Cutoff dysfunction examination executive executive functioning feature fluency Frontal in both groups individual less Measures medical records Mini-Mental State Examination Neuroinvasive Neuropsychology Orientation outcome Patient patients predominant premorbid risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient state variable [DOI] 10.1007/s10072-022-06130-8 PMC 바로가기 [Article Type] Article
Treating the body to prevent brain injury: lessons learned from the coronavirus disease 2019 pandemic뇌 손상을 예방하기 위한 신체 치료: 2019년 코로나바이러스 전염병에서 배운 교훈Review Published on 2022-04-012022-09-11 Journal: Current opinion in critical care [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, [키워드] Brain coronavirus disease COVID-19 discharge Doppler edema Electroencephalography emboli Encephalopathy epileptic Evidence Frontal Hypoxemia infrared spectroscopy Intervention intracranial pressure invasive large vessel Limited management marker morbidity morbidity and mortality near-infrared spectroscopy neurologic Neurological complication Neurological complications Occurrence optic nerve optic nerve sheath oxygen Oxygenation pandemic parameter patients with COVID-19 peripheral oxygen saturation Prevent Pupillometry recent reduce transcranial Doppler treating utility [DOI] 10.1097/MCC.0000000000000917 PMC 바로가기 [Article Type] Review
Diagnostic Performance of a Deep Learning Model Deployed at a National COVID-19 Screening Facility for Detection of Pneumonia on Frontal Chest RadiographsArticle Published on 2022-01-172022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] 95% confidence interval Algorithm Area artificial AUC average baseline calculated characteristic Chest radiograph COVID-19 COVID-19 pandemic CXR dataset datasets deep Degradation detect detection develop diagnostic facility Frontal hospital implementation initial input intelligence learning mass chest Model NIH performance Pneumonia positive provided Radiograph radiological radiologist reference standard Screening sensitivity specificity statistically significant the mean unique was reduced X-ray [DOI] 10.3390/healthcare10010175 PMC 바로가기 [Article Type] Article
Intermittent Frontal Rhythmic Discharges as an Electroencephalogram Biomarker of Acute SARS-CoV-2 Infection-Associated Encephalopathy in ChildrenNeurology Published on 2021-10-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Adults Agitation Autoimmune Biomarker blood glucose brain MRI Characteristics children clinical recovery Cohort cohort of patient Confusion COVID-19 infection CSF Culture Diabetes Mellitus discharge EEG electroencephalogram Encephalopathy female Fever Follow-up Frontal frontal intermittent rhythmic discharges headache Headaches High-dose implication Inflammatory response Intermittent Neuroinvasive neurological neurological manifestation Neurological symptoms nonspecific observational study Patient PCR pediatric pediatric COVID-19 Pediatric patients positive RBCs reported reported symptom respiratory symptoms SARS-CoV-2 SARS-CoV-2 PCR Seizure steroid subsequent Symptom syndrome the SARS-CoV-2 virus WBCs weakness [DOI] 10.7759/cureus.19149 PMC 바로가기 [Article Type] Neurology
Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patientsCOVID-19 환자의 전두엽 피질에서 SARS-CoV-2 게놈 및 전체 전사체 시퀀싱 검출Article Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] affected Analysis Brain categories category Control controls COVID-19 COVID-19 patient COVID-19 patients Defense demonstrated Deprivation detection died downregulation dysfunction examined expressed Frontal Frontal cortex Gene Expression hemoglobin hydrogen hydrogen peroxide hypoxia infect Infection inhibit investigated lncRNA Manifestations molecular mRNA mRNAs multi nervous neurological organ Patient Protein qRT-PCR quantity remains uncertain replicate RNA-seq analysis SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection Structure System tissue transcriptional Transcriptome transcriptome sequencing transcriptomic analysis transcriptomic profile Viral RNA [DOI] 10.1016/j.bbi.2021.05.012 PMC 바로가기 [Article Type] Article
COVID-19 patients and Dementia: Frontal cortex transcriptomic dataData Article Published on 2021-09-292022-10-31 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, [키워드] affected Analysis association Brain cortex COVID-19 COVID-19 patient COVID-19 positive patient criteria detection differential expression examined Frontal Gene Expression gene expression difference Genes Guaita individual individuals individuals with COVID-19 Infection isoforms Manifestations Medici mRNA nervous non-COVID-19 patient Patient performed positive protein coding genes Research RNA-sequencing SARS-CoV-2 SARS-CoV-2 genome System transcript transcriptome sequencing transcriptomic data transcriptomics [DOI] 10.1016/j.dib.2021.107432 PMC 바로가기 [Article Type] Data Article
Neuropsychological Pattern in a Series of Post-Acute COVID-19 Patients in a Rehabilitation Unit: Retrospective Analysis and Correlation with Functional OutcomesCase Report Published on 2021-05-312022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Admission alteration analyzed Anxiety assessment Barthel Index battery Brescia cognitive complex correlated correlation COVID-19 COVID-19 infection delirium described disorder evaluated Forward Frontal functional functions impairment Insomnia intensive care unit memory Neuropsychological assessment outcomes Patient patients patients with COVID-19 pattern Pneumonia recovering from COVID-19 rehabilitation Sery Spearman subsequent Tower of London verbal [DOI] 10.3390/ijerph18115917 PMC 바로가기 [Article Type] Case Report