Functional enrichment analysis – Communicable Diseases Research

The potential mechanism of the Ruhao Dashi formula in treating acute pneumonia via network pharmacology and molecular docking

4200

Published on 2023-03-172024-09-05
Journal: Medicine [Category] update2024,

IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA

Article

Published on 2022-09-152022-11-15
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1,25-dihydroxy vitamin D3 activated acute respiratory syndrome analyses Analysis applied autoimmune conditions Bacteremia Bacterial Bacterial infection Bacterial infections Bioinformatics analysis Biomarker caused Cell cell membrane CIBERSORT conducted coronavirus COVID-19 Cytoscape database dataset datasets DEGs dendritic cell dendritic cells dendritic cells. differentially expressed differentially expressed gene disease DNA drug target Effectiveness examined expression FIVE functional enrichment Functional enrichment analysis GBP1 gene network GeneMANIA Genes global pandemic HERC5 humans identify Ifi44 IFI44L IFIT3 IFIT5 IFN signaling IFN signaling pathway IFN-α/β Immune cell infiltration immune cells Immune escape immune evasion immune system Immunological response Infection infections infiltration Intersection ISG15 KEGG mechanism miRNA molecular mechanism molecular target NLR OAS1 oxidative phosphorylation pathogenic bacteria pathway Patient platform positive correlation PPI network prevalent proliferation promote regulate Regulation Rheumatoid rheumatoid arthritis risk factor ROC curves RSAD2 Rtp4 SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease signaling pathway Staphylococcus Staphylococcus aureus target the SARS-CoV-2 therapeutic viral infection viral replication virus were used YY1
[DOI] 10.3389/fimmu.2022.1013322 PMC 바로가기

Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 Disease

COVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석

Review

Published on 2022-08-172022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘,

[키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization
[DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review

Enrichment analysis on regulatory subspaces: A novel direction for the superior description of cellular responses to SARS-CoV-2

규제 부분 공간에 대한 농축 분석: SARS-CoV-2에 대한 세포 반응의 우수한 설명을 위한 새로운 방향

Article

Published on 2022-07-012022-09-11
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자,

[키워드] affected Algorithm Analysis applied Biclustering Cell cell line cellular response Characteristics classic Clustering Comparative analysis complex Computational biology Coverage COVID-19 database Discriminative regulatory patterns enrichment enrichment analysis False positive functional enrichment Functional enrichment analysis GO term GO terms H1N1 IAV identify Impact IMPROVE in vivo infected cell infected cells Interaction KEGG pathway knowledge knowledge extraction lack lung cell line lung cell lines machine machine learning machine learning algorithm machine learning approach motivation observations pathophysiological performed Predictive Regulatory RSV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scarcity significantly the SARS-CoV-2 virus transcriptional response transcriptomic data transcriptomics variant virus viruses
[DOI] 10.1016/j.compbiomed.2022.105443 PMC 바로가기 [Article Type] Article

Analysis of mechanisms of Shenhuang Granule in treating severe COVID-19 based on network pharmacology and molecular docking

Research article

Published on 2022-07-012022-10-05
Journal: Journal of integrative medicine [Category] 유전자 메커니즘, 임상,

[키워드] ABCB1 acute respiratory syndrome Analysis Calcium signaling CAMP Chinese complex component coronavirus coronavirus disease COVID-19 CXCL8 Cytokine storm database DNMT1 docking effective enrichment analysis expected experiments Functional enrichment analysis Gene Expression Omnibus GEO Granule HDAC3 Helicase HSP90AA1 IFNg indicated inhibit Interaction Invasion MDM2 mechanism mechanisms mild cases MMP9 molecular docking Molecular dynamics simulation Multiple network pharmacology neuroactive objective pathway performed platform predicted protein targets Protein–protein interaction provide PTGS2 randomized clinical trial regulated Result Safe SARS-CoV-2 severe COVID-19 Shenhuang granule shown Signaling signaling pathway stability SwissTargetPrediction target therapeutic target therapeutic targets Treatment TYMS virus were used worse prognosis
[DOI] 10.1016/j.joim.2022.07.005 [Article Type] Research article

Identification of critical genes and molecular pathways in COVID-19 myocarditis and constructing gene regulatory networks by bioinformatic analysis

코로나19 심근염의 핵심 유전자 및 분자경로 규명 및 생물정보분석을 통한 유전자 조절 네트워크 구축

Article

Published on 2022-06-242022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] adjusted Algorithms Analysis bioinformatic analysis bioinformatics biological processe biological processes CDC20 CDK1 Cell cell cycle Compound correlation COVID-19 Critical Cytoscape dataset DEGs differentially expressed gene down-regulated genes drug drugs enrichment analysis etoposide Evidence evidence of fold Functional enrichment analyses Functional enrichment analysis Gene Expression Gene Expression Omnibus gene regulatory network Genes GEO highlighting hydrolysis identification identify in vitro indicated infected with SARS-CoV-2 Interaction KIF20A KIF2C mechanism methotrexate molecular myocarditis network analysis overlapped P-value Pathogenesis pathway Patient PBK performed Perspective pluripotent stem cell Potential biomarker potential biomarkers PPI probe protein-protein interaction provide R software Regulatory signature target transcription factor Treatment Troglitazone turquoise module UBE2C up-regulated was used website were assessed WGCNA with COVID-19
[DOI] 10.1371/journal.pone.0269386 PMC 바로가기 [Article Type] Article

Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related Stroke

COVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석

Article

Published on 2022-05-092022-09-11
Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘,

Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity

Medicine

Published on 2022-01-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] association change characterized COVID-19 COVID-19 disease severity COVID-19 patient COVID-19 severity diabete Diabetes Mellitus Diabetic diabetic patient diabetic patients diagnostic disease severity docosahexaenoic acid docosapentaenoic acid exhibiting Fatty acid FDR Functional enrichment analysis hypertension hypertensive patient hypertensive patients identify Increased metabolic metabolic pathway metabolomics oleic acid palmitic acid pathway Patient patients with diabete Polyunsaturated reduced serum sample severe COVID-19 signature significant changes in Tandem mass spectrometry therapeutic targets triacylglycerol triacylglycerols Type type 2 diabete unsaturated was performed
[DOI] 10.3389/fmed.2021.788687 PMC 바로가기 [Article Type] Medicine

Identification of the Key Immune-Related Genes in Chronic Obstructive Pulmonary Disease Based on Immune Infiltration Analysis

면역 침윤 분석을 기반으로 한 만성 폐쇄성 폐 질환의 주요 면역 관련 유전자 식별

Article

Published on 2022-01-042022-09-11
Journal: International journal of chronic obstructive pulmo [Category] SARS, 유전자 메커니즘,

[키워드] activated AHNAK Algorithm Analysis biological processe Biomarker cause of death chronic chronic obstructive chronic obstructive pulmonary disease CIBERSORT complex mechanism conducted COPD coronavirus disease coronavirus disease COVID-19 correlation Correlation analysis correlations CXCR1 CXCR2 database dataset death defined DEGs dendritic cell dendritic cells Diagnosis diagnostic biomarker Diagnostic biomarkers differentially expressed gene Differentially expressed genes downloaded enrichment analysis expressed FCGR3B follicular fraction Fractions Functional enrichment analyses Functional enrichment analysis Gene ontology Genes greater helper T cell hub genes identification Immune cell immune cells immune-related gene immune-related genes immune-related genes. Ingenuity Pathway Analysis Interaction investigated IPA IRGs KEGG Kyoto lung tissue morbidity neutrophil Neutrophils NK cells Obstructive obstructive pulmonary disease pathway Pathways Patient potential mechanism PPI progression proportion proportions protein-protein interaction pulmonary pulmonary disease significantly SLIT2 subset T cells Treatment
[DOI] 10.2147/COPD.S333251 PMC 바로가기 [Article Type] Article

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking

네트워크 약리학 및 분자 도킹을 기반으로 Covid-19에 대한 수 헥치 안약의 잠재적 메커니즘 탐색

4200

Published on 2021-12-232022-08-31
Journal: Medicine [Category] 유전자 메커니즘, 치료제,

[키워드] activator Analysis Anti-viral applied AutoDock binding affinity biological processe cells chemokine Chinese classic collected Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytokine storm Cytoscape software database Diagnosis disease endothelial epidermal epidermal growth factor Functional enrichment analysis GeneCard Genes growth factor guideline hub genes hypoxia immune function immune system include inflammatory storm ingredient interleukin interleukin 17 interleukin 6 Intersection janus Janus kinase KEGG Kyoto mechanism moderate molecular docking molecular mechanism Necrosis network pharmacology Ontology pathway enrichment Pathways phosphatidylinositol phosphatidylinositol 3-kinase PI3K pill plague platform potential mechanism potential therapeutic targets predicted Protein kinase B protein-protein interaction R language receptor Regulation screened severe COVID-19 signaling pathways STAT3 suggested suhexiang pill synergistic T cell T cell receptor target target gene Target genes targets TNF Traditional Chinese medicine Transcription Treatment Tumor tumor necrosis tumor necrosis factor Vascular Viral viral invasion was used
[DOI] 10.1097/MD.0000000000027112 PMC 바로가기 [Article Type] 4200