Non-glycosylated G protein with CpG ODN provides robust protection against respiratory syncytial virus without inducing eosinophiliaImmunology Original Research Published on 2023-12-192024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] adjuvant CpG oligodeoxynucleotide eosinophil G protein respiratory syncytial virus Vaccine [DOI] 10.3389/fimmu.2023.1282016 PMC 바로가기 [Article Type] Immunology Original Research
β-arrestins and G protein-coupled receptor kinases in viral entry: A graphical reviewReview Published on 2023-02-012023-07-11 Journal: Cellular signalling [Category] COVID19(2023년), [키워드] B-arrestin clathrin endocytosis Filovirus flavivirus G protein GPCR GRK Influenza virus Polyomavirus Signaling virus [DOI] 10.1016/j.cellsig.2022.110558 [Article Type] Review
Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection sartans Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Alpha antagonist antagonists applied BA.1 Beta Caco2 cells Cathepsin-L cell entry cells cellular entry chlorpromazine Combination Compound D614G Delta drug Drug repurposing Drug screening Entry inhibitor FDA-approved drugs G protein G protein coupled receptor antagonist G-protein help highest identify Infection route inhibit inhibitors lentiviral Lentiviral vector lentiviral vectors mechanism membrane fusion omicron pathway phenothiazine preference pseudotyped pseudovirus pseudoviruses receptor receptor antagonist Receptor binding receptors respiratory responsible resulting SARS-CoV-2 several variant several variants Severe acute respiratory syndrome specific inhibitors spike variant synergistic targets TMPRSS2 variant variant of concern viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
Delayed respiratory syncytial virus outbreak in 2020 in Taiwan was correlated with two novel RSV-A genotype ON1 variants2020년 대만에서 지연된 호흡기 세포융합 바이러스 발병은 2개의 새로운 RSV-A 유전자형 ON1 변이체와 상관관계가 있었습니다Article Published on 2022-05-012022-09-11 Journal: Influenza and Other Respiratory Viruses [Category] MERS, 변종, 진단, [키워드] Affect Amino acid amino acid substitution Analysis analyzed association caused children Clinical characteristics Clinical data Cluster conducted correlated COVID-19 mitigation measures Delayed demonstrated determine disease Epidemiology exploration Factor G protein Genotype greater Hospital admission Hospitalized Human Human respiratory syncytial virus Infant Infants Infection Molecular epidemiology MOST nasopharyngeal sample Nasopharyngeal samples need for oxygen outbreak oxygen pathogen Patient patient data performed Phylogenetic analysis positive profile proportion recorded respiratory respiratory syncytial virus respiratory tract RSV sequenced steroid steroid therapy strain Taiwan therapy variant variants Viral [DOI] 10.1111/irv.12951 PMC 바로가기 [Article Type] Article
Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine경구 랍도바이러스 백신을 사용한 비인간 영장류의 SARS-CoV-2 면역 강화Article Published on 2022-04-012022-09-12 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] administration cell tropism clinical clinical trials cynomolgus macaques effort G protein help immune response Immunity intramuscular Lipid nanoparticle Neutralizing antibodies oral Oral vaccine parental poorly immunogenic Rhabdovirus SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike glycoprotein stomatitis T cells vaccinated individual Vaccine virion virus VSV VSV. [DOI] 10.1016/j.vaccine.2021.12.063 PMC 바로가기 [Article Type] Article
Immunogenicity of a recombinant VSV-Vectored SARS-CoV vaccine induced robust immunity in rhesus monkeys after single-dose immunization재조합 VSV-Vectored SARS-CoV 백신의 면역원성은 단일 용량 면역 후 붉은털 원숭이에서 강력한 면역을 유도했습니다Article Published on 2022-04-012022-09-12 Journal: Virologica Sinica [Category] SARS, 진단, [키워드] accumulate acute respiratory syndrome animal models can be used caused chimeric China contagious coronavirus coronavirus disease COVID-19 death disease dose effective G protein glycoprotein Guangdong heterogeneous human population humans Immunity immunization immunogenic antigen immunogenicity indicate induce Infection maintain mice Neutralizing antibodies neutralizing antibody New coronavirus non-human primate novel coronavirus disease outbreak Protein rapid response replaced reported Rhesus monkey robust S protein Safe SARS Coronavirus SARS-CoV SARS-CoV S SARS-CoV vaccine severe acute respiratory syndrome coronavirus (SARS-CoV) spike T cell response TCID Trial Vaccine vaccine candidate Vaccine development vesicular stomatitis vesicular stomatitis virus vesicular stomatitis virus (VSV) virus VSV zoonotic disease [DOI] 10.1016/j.virs.2022.01.002 PMC 바로가기 [Article Type] Article
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severityGPCR 및 RAS 관련 분자를 표적으로 하는 자가항체는 COVID-19 중증도와 연관Article Published on 2022-03-092022-09-11 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] AGTR1 alteration antibody antibody levels association autoantibodies autoantibody characterized Chemokine receptor chemokine receptor CXCR3 Clinical severity component COVID-19 COVID-19 disease COVID-19 disease severity cross-sectional cross-sectional study CXCR3 deregulated disease severity G protein G protein-coupled receptor G protein-coupled receptors healthy control healthy controls human biology identify immune individuals Mild Mild COVID-19 disease moderate Pathogenesis Patient predict Previous studies previous study severe disease severity Systemic autoimmune diseases target targets the disease the strongest with COVID-19 [DOI] 10.1038/s41467-022-28905-5 PMC 바로가기 [Article Type] Article
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B2R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Optical imaging spectroscopy for rapid, primary screening of SARS-CoV-2: a proof of conceptArticle Published on 2022-02-182022-10-29 Journal: Scientific Reports [Category] COVID-19, COVID19(2023년), SARS, [키워드] Analysis coronavirus disease COVID-19 G protein human saliva information Lentiviral particle molecular test nasopharyngeal near-infrared spectroscopy optical Patient PCR-negative point-of-care pseudotyped Quantitative analysis reduce required saline solution Saliva SARS-CoV-2 SARS-CoV-2 viral loads screening strategy specificity symptomatic cases the SARS-CoV-2 the spike protein Transmission vesicular stomatitis virus viral infection [DOI] 10.1038/s41598-022-06393-3 PMC 바로가기 [Article Type] Article