Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1article Published on 2023-05-242024-09-04 Journal: Clinical and experimental immunology [Category] 대상포진, [키워드] Chronic mucocutaneous candidiasis Gain of function inborn errors of immunity loss of function Mendelian susceptibility to mycobacteria Stat1 [DOI] 10.1093/cei/uxac106 PMC 바로가기 [Article Type] article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”Letter to the Editor Published on 2023-04-252024-09-05 Journal: mBio [Category] update2024, [키워드] biosafety coronavirus COVID-19 Gain of function pandemic SARS-CoV2 zoonosis [DOI] 10.1128/mbio.00815-23 PMC 바로가기 [Article Type] Letter to the Editor
The Need for Modernization of Biosecurity in the Post-COVID WorldCommentary Published on 2022-02-282023-06-16 Journal: mSphere [Category] COVID19(2023년), MERS, SARS, [키워드] biosecurity COVID-19 Gain of function modernization [DOI] 10.1128/msphere.00025-22 PMC 바로가기 [Article Type] Commentary
COVID‐19 and the gain of function debates Improving biosafety measures requires a more precise definition of which experiments would raise safety concernsCOVID-19 및 기능 획득 논쟁 생물안전 조치를 개선하려면 어떤 실험이 안전 문제를 일으킬 것인지에 대한 보다 정확한 정의가 필요합니다Comment Published on 2021-09-032022-09-10 Journal: EMBO Reports [Category] MERS, SARS, 변종, [키워드] biosafety COVID‐19 debate debates Economics, Law & Politics experiment experiments Gain of function Improving measure Microbiology, Virology & Host Pathogen Interaction pandemic raise risk Science Policy & Publishing [DOI] 10.15252/embr.202153739 PMC 바로가기 [Article Type] Comment
Immune cartography of macrophage activation syndrome in the COVID-19 era코로나19 시대 대식세포 활성화 증후군의 면역 지도 촬영Review Published on 2021-03-012022-09-11 Journal: Nature reviews. Rheumatology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptive alveolitis antigen receptor Arthritis Cancer Cancer immunotherapy cancers CAR Cell therapy chimeric antigen receptor complex interplay Connective tissue diseases continuum COVID-19 COVID-19 pneumonia Cytokine storm develop disease disparate dominant feature Gain Gain of function genetics Hyperinflammatory hypersensitivity immune immune function Immunity immunodeficiency immunological immunological disease immunothrombosis Implications in some Infection infectious innate and adaptive immunity innate immune juvenile idiopathic arthritis limit limits Macrophage macrophage activation syndrome MHC class MHC class II occur offer patients with COVID-19 Pneumonia provide responses second wave Sepsis severe inflammation Still T cell therapeutic therapy Trigger triggers type I interferon variant [DOI] 10.1038/s41584-020-00571-1 PMC 바로가기 [Article Type] Review
Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a reviewReview Published on 2021-02-042022-10-31 Journal: Environmental Chemistry Letters [Category] COVID-19, [키워드] bioinformatics biosafety caused China consequence coronavirus CoV COVID-19 COVID-19 pandemic death determine develop dissemination Epidemics Evolution French furin Gain of function genome analysis Infection inferences Intensive Interaction involved knowledge Laboratory mechanism molecular mechanism pandemic Phylogenetic Phylogeny Prevent Proteins question responsible SARS-CoV-2 SARS-CoV2 Sequence analysis Spike protein supplementary material therapeutic tracing translation understanding Vaccine Virology virus zoonoses zoonosis zoonotic [DOI] 10.1007/s10311-020-01151-1 PMC 바로가기 [Article Type] Review
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?심각한 COVID-19의 림프구 변화: STING의 지연된 과활성화?Review Published on 2020-12-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] ACE2 activated Activation acute respiratory syndrome affected antigen presenting cell antigen presenting cells Aspirin autophagy B cell B cell response B cells CD147 CD26 CD4+ CD8+ CD8+ T cell cGAMP cGAS change contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic cytokine cytokine secretion damages Delayed dinucleotide DNA DNA damage early stages Express expressed functional Gain of function Genes Host Human IL-6 immune cells induce infancy Infection inhibit inhibitor interferon IRF3 Last less lymphocyte Lymphocytes lymphopenia main receptor microbial NF-κB pathway Pneumonitis Recognition respiratory responsiveness SARS-CoV-2 severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients similarity SLC19A1 small molecule Small molecules stimulator STING T and B cell responses T cell T cells TBK1 TCR Th2 transfer triggered Vasculopathy [DOI] 10.3389/fimmu.2020.607069 PMC 바로가기 [Article Type] Review
Structural Variants Create New Topological-Associated Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis Pigmentosa구조적 변이체는 우성 색소성 망막염에서 새로운 위상 관련 도메인 및 이소성 망막 인핸서-유전자 접촉을 생성합니다Article Published on 2020-10-052022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] adRP affected Altered binding site blindness breakpoint Cell characterized Chr17q22 complex Contact Control creation differential expression disease domain dominant dominant retinitis pigmentosa ectopic ectopic expression enhancer enhancers Epigenetic Families fibroblast fibroblasts Gain of function GDPD GDPD1 Genome sequencing genomic genomic region genotyping Hi-C highlight increased expression individual individuals investigated leads LINC01476 locus loss of vision mechanism Mendelian diseases modeling Molecular diagnosis New photoreceptor photoreceptor precursors cells pluripotent stem cell PPCs precursor qPCR resulting Retinal retinal enhancer retinal expression retinal organoid retinal organoids retinal-specific enhancer Retinitis retinitis pigmentosa RNA RP17 stem cells Structural variant structural variants SVs topologically associated domains transcription factors vision was performed whole-genome sequencing YPEL2 [DOI] 10.1016/j.ajhg.2020.09.002 PMC 바로가기 [Article Type] Article
Application of a Biologically Contained Reporter System To Study Gain-of-Function H5N1 Influenza A Viruses with Pandemic PotentialArticle Published on 2020-08-262023-06-08 Journal: mSphere [Category] 신종인플루엔자, [키워드] Antiviral agents avian viruses biological containment biosafety Gain of function H5N1 Influenza reporter genes [DOI] 10.1128/mSphere.00423-20 PMC 바로가기
STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal DephosphorylationOriginal Research Published on 2019-07-102024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] dephosphorylation Gain of function jak inhibitors Monocytes mRNA Protein Stat1 T cells [DOI] 10.3389/fimmu.2019.01433 PMC 바로가기 [Article Type] Original Research