Characteristics of RNA Stabilizer RNApro for Peripheral Blood CollectionArticle Published on 2024-05-072024-09-05 Journal: Diagnostics [Category] update2024, [키워드] GAPDH guanidinium thiocyanate RNA extraction RNA stabilizers RNApro [DOI] 10.3390/diagnostics14100971 PMC 바로가기 [Article Type] Article
Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host CellsBrief Report Published on 2024-02-072024-09-05 Journal: Journal of innate immunity [Category] update2024, [키워드] ACE2 GAPDH inhibition Innate immune defense severe acute respiratory syndrome coronavirus-2 [DOI] 10.1159/000535634 PMC 바로가기 [Article Type] Brief Report
Novel electrochemical PMI marker biosensor based on quantum dot dissolution using a double-label strategy Research Published on 2022-05-252022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis antibody applicability Biomarker Characteristics Concentration conducted detect determine ENhance GAPDH hydrogen peroxide Interaction introduced limit of detection linear marker monoclonal novel Post-mortem sensitivity stability was used [DOI] 10.1038/s41598-022-12444-6 [Article Type] Research
Colonic Epithelial Angiotensin-Converting Enzyme 2 (ACE2) Expression in Blacks and Whites: Potential Implications for Pathogenesis Covid-19 Racial Disparities흑인과 백인의 결장 상피 안지오텐신 전환 효소 2(ACE2) 발현: 발병 원인 Covid-19 인종 격차에 대한 잠재적 의미Article Published on 2022-04-012022-09-11 Journal: Journal of racial and ethnic health disparities [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Actin age Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Beta beta-actin biopsy black BMI cell receptor Chain Reaction concert correlation COVID-19 COVID-19 infections Cytokine storm disparity downregulation epithelial epithelial cell expression fold GAPDH Gender host protein immune response Infection Inflammation Inflammatory response knowledge mechanism Mortality mRNA mucosal multivariable multivariable analyses multivariable analysis neoplasia normalization not altered Perspective polymerase chain polymerase chain reaction Potential protease Racial Racial disparities real-time polymerase chain reaction rectal mucosa Serine serine 2 severity statistical significance suppress susceptibility targets TMPRSS2 TMPRSS2 level TMPRSS2 levels TMRPSS2 Total transmembrane transmembrane protease serine 2 univariable was performed were used white [DOI] 10.1007/s40615-021-01004-9 PMC 바로가기 [Article Type] Article
Evaluation of an Automated High-Throughput Liquid-Based RNA Extraction Platform on Pooled Nasopharyngeal or Saliva Specimens for SARS-CoV-2 RT-PCRSARS-CoV-2 RT-PCR에 대한 풀링된 비인두 또는 타액 표본에 대한 자동화된 고처리량 액체 기반 RNA 추출 플랫폼 평가Article Published on 2021-04-022022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] automated comparable COVID-19 COVID-19 pandemic Ct values detect diagnostics Efficiency extraction GAPDH inhibitors Large-scale testing liquid-based nucleic acid extraction magnetic bead Mass screening Nasopharyngeal swab no significant differences nucleic acid nucleic acid extraction Oropharyngeal paucity of data platform pooled specimens positive positive rate real-time RT-PCR RNA RNA extraction RT-PCR Saliva saliva specimen saliva specimens SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 RT-PCR significant difference significant differences specimen specimens the SARS-CoV-2 was performed was used [DOI] 10.3390/v13040615 PMC 바로가기 [Article Type] Article
Diseasome and comorbidities complexities of SARS-CoV-2 infection with common malignant diseases일반적인 악성 질환과 SARS-CoV-2 감염의 질병 및 동반 질환 복잡성Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] ACTB APCDD1 approach bioinformatics Bioinformatics analysis Cancer cancer patient Cancer patients cancers CASP1 cell activation chemokine CHI3L1 CLEC1B COL6A3 Colon Comorbidities Comorbidity conditions COVID-19 CXCL10 CXCL8 cytokine cytokine production dataset DDIT4 deregulated develop disease diseasome dysregulated FABP5 FN1 GAPDH Gene Expression Omnibus Genes GPNMB higher risk HMOX1 identify IGFBP3 immune systems JUND kidney LGALS1 Lungs malignant disease malignant tumors Marco molecular Mortality MSH3 MYO10 NPC2 OAS2 Ontology outcome pathway Pathways PRDX3 ribosome biogenesis S100A8 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections semantic similarity severity signaling pathway synergistic SYTL2 the disease Thyroid Timp1 transcriptomic transcriptomic data tumors VCAN Wnt signaling pathway [DOI] 10.1093/bib/bbab003 PMC 바로가기 [Article Type] Article
Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patientsResearch Article Published on 2020-12-212022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] blood cell bronchoalveolar Cell cells cellular cellular response characterized clinical manifestations COVID-19 COVID-19 patient COVID-19 severity Critically ill CXCL8 CXCR1 CXCR2 event events explain Express expressed expression FIVE GAPDH Genes HIF1α hypoxia immature immature myeloid cells Immunopathogenesis Increased Inflammation involved leukocyte lung cell marker metabolism molecular monocyte monocyte-macrophages Monocytes mRNA myeloid cell Neutrophils oxygen levels performed peripheral blood cells PFKFB3 PGK1 physiological response potential molecular precursors regulated Result RNAseq SARS-CoV-2 scRNAseq severe cases SLC2A3 SOD2 subset target targets therapy TLR TLR2 transcription factor transcriptional transcriptionally virus [DOI] 10.1080/07853890.2020.1858234 PMC 바로가기 [Article Type] Research Article
Interferon‐stimulated gene products as regulators of central carbon metabolismViewpoint Published on 2020-12-012022-10-31 Journal: The Febs Journal [Category] Coronavirus, MERS, SARS, [키워드] activate analyses Antigen antiviral immune response antiviral response biochemical carbon metabolism cellular COVID‐19 eicosanoid enzyme Evidence expression GAPDH gene product help immune response immunometabolism individual inhibit inhibiting innate immune response innate immune system interfere ISG ISGs mechanism metabolic product metabolite modulate modulating NFAT nitric oxide NOS Pathways performed Protein Proteins reaction regulate RSAD2 SAM stimulate Support viperin viral disease viral infections viral life cycle Viral proteins viral replication viruses [DOI] 10.1111/febs.15625 PMC 바로가기 [Article Type] Viewpoint
Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacologyResearch Published on 2020-10-162022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing [DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis갑상선 세포에서 SARS-COV-2 수용체 ACE-2 mRNA 검출: 코로나19 관련 아급성 갑상선염의 단서Original Article Published on 2020-10-062022-09-10 Journal: Journal of Endocrinological Investigation [Category] MERS, 진단, 치료제, [키워드] ACE-2 ACE-2 receptor angiotensin Angiotensin-converting enzyme carboxypeptidase Cell cell cultures cells cellular entry clinical study coronavirus COVID-19 described detection enzyme Ex vivo expressed expression follicular follicular cell follicular cells Future GAPDH human tissue in vitro independent involved mRNA nodules pandemic pathogenic pathway Patient patients with COVID-19 primary culture receptor Renin Renin-Angiotensin pathway reporter reporter genes required responsible Result RT-PCR SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection surgical the mean Thyrocytes Thyroid thyroid follicular cells thyroid nodules thyroidectomy Thyroiditis tissue sample tissues transcript transmembrane type I was performed β-actin [DOI] 10.1007/s40618-020-01436-w PMC 바로가기 [Article Type] Original Article