An Insight into Modern Targeted Genome-Editing Technologies with a Special Focus on CRISPR/Cas9 and its ApplicationsReview Published on 2023-02-012023-07-09 Journal: Molecular biotechnology [Category] COVID19(2023년), [키워드] CRISPR/Cas9 gene editing meganuclease SARS-CoV2 TALENs. [DOI] 10.1007/s12033-022-00501-4 PMC 바로가기 [Article Type] Review
Gene Editing Technologies to Target HBV cccDNAReview Published on 2022-11-282023-06-12 Journal: Viruses [Category] B형 간염, [키워드] base editing cccDNA CRISPR/Cas gene editing HBV Hepatitis B virus meganuclease. TALEN ZNF [DOI] 10.3390/v14122654 PMC 바로가기 [Article Type] Review
Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivoArticle Published on 2022-09-072023-06-12 Journal: Molecular therapy : the journal of the American So [Category] B형 간염, [키워드] AAV ARCUS gene editing Gene therapy HBsAg HBV hepatitis B LNP meganuclease. NHP [DOI] 10.1016/j.ymthe.2022.05.013 PMC 바로가기
Recent advances in delivering RNA-based therapeutics to mitochondriaReview Published on 2022-09-012023-07-09 Journal: Expert opinion on biological therapy [Category] COVID19(2023년), [키워드] drug delivery system gene editing gene therapy. MITO-Porter Mitochondria RNA delivery therapy [DOI] 10.1080/14712598.2022.2070427 PMC 바로가기 [Article Type] Review
New strategies for the treatment of chronic hepatitis BReview Published on 2022-09-012023-06-12 Journal: Trends in molecular medicine [Category] B형 간염, [키워드] cccDNA functional cure gene editing Hepatitis B virus. RNA interference [DOI] 10.1016/j.molmed.2022.06.002 PMC 바로가기 [Article Type] Review
The State-of-the-Art of Gene Editing and its Application to Viral Infections and Diseases Including COVID-19최신 유전자 편집 기술과 코로나19를 포함한 바이러스 감염 및 질병에 적용Review Published on 2022-06-092022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral application Biotechnology Cas9 caused combating contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CRISPR CRISPR-Cas9 CRISPR/Cas9 diagnostic disease Disease progression Diseases domain feature gene editing Gene therapy help highlight highly pathogenic implication Including Infectious diseases mechanism Multiple pandemic pandemic disease public health SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown therapeutic therapy Vaccines viral infection Viral infection. virus [DOI] 10.3389/fcimb.2022.869889 PMC 바로가기 [Article Type] Review
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapyResearch article Published on 2022-03-012022-10-05 Journal: Bioactive Materials [Category] Coronavirus, 비임상, [키워드] accumulated addition adverse effect Cancer therapy cancer treatment Cas9 cells CRISPR/Cas DNA Efficiency element encapsulate expressing Factor gene editing in vitro in vivo Intravenous injection kidneys lack Lipid nanoparticle liver Neutral nucleic acid organ Plasmid PLK1 Protein provide regimen RNA robust Safe sgRNA significantly siRNA triggered tumor growth [DOI] 10.1016/j.bioactmat.2021.05.051 [Article Type] Research article
Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infectionsReview Published on 2022-02-252023-06-03 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] B형 간염, COVID19(2023년), MERS, SARS, [키워드] CRISPR-Cas gene editing Infection Treatment virus [DOI] 10.1016/j.biopha.2022.112743 PMC 바로가기 [Article Type] Review
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsReview Published on 2022-02-112022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] approval approved candidate clinically COVID-19 delivery develop disease Efficacy Emergency use evaluated gene editing genetic disease Genetic diseases global pandemic issue lesson Lipid Lipid nanoparticles LNP mRNA mRNA platform mRNA-based mRNA-based therapeutics mRNA-based vaccine mRNA-LNP nanoparticle Onpattro Pharmaceutics platform prophylactic vaccines PROTECT SARS-COV-2 infection siRNA-LNP Spread System therapeutic Therapeutics translation treat Treatment University of Pennsylvania utility Vaccine [DOI] 10.3390/pharmaceutics14020398 PMC 바로가기 [Article Type] Review
CRISPR Technology in Gene-Editing-Based Detection and Treatment of SARS-CoV-2Molecular Biosciences Published on 2022-01-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE-2 receptors acute respiratory syndrome approach caused changes in coronavirus coronavirus disease Coronaviruses COVID-19 CRISPR CRISPR/Cas9 detection Diagnosis disease DNA double-stranded gene editing genetic information Genome human-to-human transmission induce palindromic repeat Prevalence problem Protein RNA SARS-CoV-2 SARS-COV-2 infection severe respiratory infections Spread suggested target gene technology Treatment Wuhan [DOI] 10.3389/fmolb.2021.772788 PMC 바로가기 [Article Type] Molecular Biosciences