Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell levelArticle Published on 2024-05-272024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Gene expression profiling Influenza virus Virus-host interactions [DOI] 10.1038/s41467-024-48934-6 PMC 바로가기 [Article Type] Article
Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signaturesShort Communication Published on 2024-02-062024-09-05 Journal: Clinical & Translational Immunology [Category] update2024, [키워드] COVID‐19 digital spatial profiling Gene expression profiling placental dysfunction SARS‐CoV‐2 trophoblasts [DOI] 10.1002/cti2.1488 PMC 바로가기 [Article Type] Short Communication
Variability in donor leukocyte counts confound the use of common RNA sequencing data normalization strategies in transcriptomic biomarker studies performed with whole bloodarticle Published on 2023-09-192024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Gene expression profiling RNA sequencing [DOI] 10.1038/s41598-023-41443-4 PMC 바로가기 [Article Type] article
Author Correction: Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohortarticle Published on 2023-09-072024-09-05 Journal: Scientific Data [Category] update2024, [키워드] Gene expression profiling SARS-CoV-2 [DOI] 10.1038/s41597-023-02504-5 PMC 바로가기 [Article Type] article
Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case SeriesBrief Report Published on 2023-07-252024-09-05 Journal: Pathobiology : journal of immunopathology, molecul [Category] update2024, [키워드] BAL Bronchoalveolar lavage COVID-19 Gene expression profiling SARS-CoV-2 [DOI] 10.1159/000532057 PMC 바로가기 [Article Type] Brief Report
Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohortarticle Published on 2023-06-142024-09-05 Journal: Scientific Data [Category] update2024, [키워드] Gene expression profiling SARS-CoV-2 [DOI] 10.1038/s41597-023-02289-7 PMC 바로가기 [Article Type] article
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severityarticle Published on 2023-04-242024-09-05 Journal: Nature genetics [Category] update2024, [키워드] Gene Expression Gene expression profiling Infectious diseases [DOI] 10.1038/s41588-023-01375-1 PMC 바로가기 [Article Type] article
Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic dataArticle Published on 2022-08-222022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Admission Analysis analyzed Antiviral antiviral immune response antiviral immune responses caused clinical feature Clinical outcome clinical outcomes Cluster CMPK2 correlated correlation COVID-19 COVID-19 clusters COVID-19 patient COVID-19 patients CXCL10 D-dimer levels dataset datasets DEGs differentially expressed gene downregulation elevated EPSTI1 expressed expression expression profile Gene expression profiling Genes HERC6 human host cells ICU identification Ifi44 IFI44L IFI6 immune immune regulation intensive care intensive care unit Invasion involved leukocyte mechanical ventilatory support modulate nasopharyngeal OAS1 OAS2 OAS3 OASL outcome reducing RSAD2 SARS-CoV-2 SARS-COV-2 infection SERPING1 severity of COVID-19 significantly tissue transcriptomic data upregulated ventilatory viral loads [DOI] 10.3389/fimmu.2022.930866 PMC 바로가기
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기