Annelid genomes: Enchytraeus crypticus , a soil model for the innate (and primed) immune systemArticle Published on 2021-09-062022-10-29 Journal: Lab Animal [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Annelid Annelida antibiotic Bioscience cell entry Combination coronavirus SARS-CoV-2 distribution elements Environmental sciences enzyme gene families Genes Genome Genomics highlight homolog horizontal gene identify Illumina immune system innate immune system Innate immunity Interaction invertebrate involved nuclear P450 platform Protein reference genome Sequencing Significant Stress transfer worm [DOI] 10.1038/s41684-021-00831-x PMC 바로가기 [Article Type] Article
Genomic epidemiology of SARS-CoV-2 in the UAE reveals novel virus mutation, patterns of co-infection and tissue specific host immune responseUAE에서 SARS-COV-2의 게놈 역학은 새로운 바이러스 돌연변이, 공동 감염 패턴 및 조직 특이 적 숙주 면역 반응을 나타낸다.Article Published on 2021-07-072022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR adenosine APOBEC APOBEC4 Bronchoalveolar lavage fluid clade Co-infection collected conducted COVID-19 epidemic cytosine defined distribution enrichment epidemiological Epidemiology Evolution expression FIVE gene families gene family Genetic variant genetics genomic Host Host immune response host response human-to-human transmission infected patients Infectious diseases innate immune Inosine Interaction knowledge Local molecular Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharynx pattern provide reported reveal SARS-CoV-2 SARS-CoV-2 evolution Sequencing subclade the SARS-CoV-2 tissue specific Transmission United Arab Emirates upregulation uracil Viral virus was related [DOI] 10.1038/s41598-021-92851-3 PMC 바로가기 [Article Type] Article
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다Research Article Published on 2018-04-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast [DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article
Comparative Genomics of the Sigatoka Disease Complex on Banana Suggests a Link between Parallel Evolutionary Changes in Pseudocercospora fijiensis and Pseudocercospora eumusae and Increased Virulence on the Banana Host바나나에 대한 Sigatoka 질병 복합체의 비교 유전체학은 Pseudocercospora fijiensis와 Pseudocercospora eumusae의 병렬 진화적 변화와 바나나 숙주의 독성 증가 사이의 연관성을 시사합니다Research Article Published on 2016-08-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation Analysis analyzed assimilation banana biological process caused cell walls change changes in Comparative Comparative analysis Comparative genomics complementary complex conserved convergent evolution core gene Degradation disease disease control Diversity Dothideomycetes driven by effective effector proteins effectors Evolution evolutionary relationships facilitate facilitated fungi gene count gene families gene family Genes Genome genome architecture genome sequence genomes genomic genomic change Genomics higher efficiency Host host immune system identify increase in Increased indicated involved LTR management metabolic pathway metabolic pathways metabolism Modification pathogen pathogenic Pathogens plant cell profile proliferation Radiation remained sequenced Seven significant difference significant differences speciation Still supported understanding utilization virulence virulent [DOI] 10.1371/journal.pgen.1005904 PMC 바로가기 [Article Type] Research Article
Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of NematodesDrechmeria coniospora의 비교 게놈 분석을 통해 선충류의 곰팡이 내부 기생충에 대한 핵심 및 특정 유전적 요구 사항이 밝혀졌습니다.Research Article Published on 2016-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adhesion Analysis arms race branch Caenorhabditis elegan Caenorhabditis elegans can be used characterisation characterized Comparative core Dissection elegan elegans Endoparasitism Evolution evolutionary arms race expresse expressed fluorescent reporter genes functional fungal Fungal infection fungi fungus Gene Expression Gene expression analysis gene families gene family Genes Genetic genetic engineering genetic transformation Genome genomic growth Host in silico infect Infection initial Interaction Interference involved kill killing knock-out knowledge lifecycle mechanism Modification molecular mycelia nematode nematodes NETs opens parasitic nematodes parasitism pathogen pathogen’ Phylogenetic analysis probe regulated reported reporter genes Requirement sequenced Specific spore Stage Tolypocladium transformation TRAP virulence [DOI] 10.1371/journal.pgen.1006017 PMC 바로가기 [Article Type] Research Article
A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga Helicosporidium절대 기생 녹조류 헬리코스포리디움의 기생 감소 부족Research Article Published on 2014-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Algae animals autotrophy biological function Biological functions categories Cell cell wall chitinases chitinous Chlorella comparable Complete complexes contraction early stage early stages Evidence Evolution example expression extreme Families function functional functions gene families gene family Genome genome maintenance genomic green Helicosporidium Host hosts infection mechanism loss of function majority malaria metabolic function molecular analysis molecular mechanisms nuclear Obligate organism Other outcome parasites parasitism photosynthesis Plasmodium predicted predominant preserved reduction retained sequenced the cell took place Transcriptome transition [DOI] 10.1371/journal.pgen.1004355 PMC 바로가기 [Article Type] Research Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article