Corrigendum: ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cellsCell and Developmental Biology Correction Published on 2024-06-212024-09-05 Journal: Frontiers in Cell and Developmental Biology [Category] update2024, [키워드] ACE2 CRISPR-Cas9 gene editing gene knockout iPS cells SARS-CoV-2 [DOI] 10.3389/fcell.2024.1407164 PMC 바로가기 [Article Type] Cell and Developmental Biology Correction
Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of MycobacteriaReview Published on 2024-05-122024-09-05 Journal: Vaccines [Category] update2024, [키워드] BCG gene knockout live attenuated vaccines (LAVs) Mycobacterium tuberculosis secretory antigens Tuberculosis [DOI] 10.3390/vaccines12050530 PMC 바로가기 [Article Type] Review
ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cellsarticle Published on 2023-12-082024-09-05 Journal: Frontiers in Cell and Developmental Biology [Category] update2024, [키워드] ACE2 CRISPR-Cas9 gene editing gene knockout iPS cells SARS-CoV-2 [DOI] 10.3389/fcell.2023.1290876 PMC 바로가기 [Article Type] article
A novel factor modulating X chromosome dosage compensation in AnophelesArticle Published on 2023-11-062024-08-28 Journal: Current Biology [Category] 말라리아, [키워드] developmental delay female-specific intron retention gene knockout malaria vector male-specific splicing tandem gene duplication.
Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice폐 실질 세포를 표적으로 하고 SARS-CoV-2-감수성 마우스를 개발하기 위한 AAV의 비침습적 투여Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 치료법, [키워드] AAV AAV2/8 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus administration Alveolar Type II angiotensin AT1 AT2 can be used Cell cells coronavirus develop enzyme expression gene delivery gene knockout Gene therapy hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 IFNAR immune immune function injected interferon receptor intratracheal administration intratracheal injection lung lung targeting. lung tissue lung tissues Lungs mice multiple lesion multiple lesions Non-invasive nucleocapsid protein parenchymal Protein pulmonary diseases receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling target technique Trachea transduced type I interferon viral titer virus [DOI] 10.1016/j.ymthe.2022.01.010 PMC 바로가기 [Article Type] Article
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells인간 윤부 줄기세포에서 SARS-CoV2 바이러스 진입 관련 단백질의 고발현Article Published on 2022-01-012022-09-11 Journal: The Ocular Surface [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ABCB5 ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed caused Cell cell population cellular cellular tropism conjunctival coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 testing Culture datasets deficiency Donor epithelial cell epithelial cells evaluated Express expression expression value flow cytometry gene knockout immunohistochemistry knockdown Limbal stem cells mechanism ocular Ocular surface overexpression Patient PAX6 promote Protein Proteins qRT-PCR regulate Regulation RNA-Seq RNAseq SARS-CoV2 SARS-CoV2 infection severe acute respiratory syndrome Coronavirus siRNA stem cell stem cells susceptibility TMPRSS2 TMPRSS2 expression transcription factor Transmission routes transplantation viral entry was performed were assessed western blot while [DOI] 10.1016/j.jtos.2021.10.002 PMC 바로가기 [Article Type] Article
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic networkResearch Article Published on 2020-11-242022-10-30 Journal: Life Science Alliance [Category] COVID-19, SARS, [키워드] Amino acid Analysis approach can be used Cell cellular central metabolism demonstrated drugs enzyme gene knockout genomic highlight Host human lung human lung cells information inhibit inhibiting Interaction nucleic acid nucleotide offer Pathways Perturbation platform predict protein expression reaction RNA interference SARS-CoV-2 virus [DOI] 10.26508/lsa.202000869 PMC 바로가기 [Article Type] Research Article
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathologyArticle Published on 2020-08-112024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] gene knockout interferon Plasmodium berghei Plasmodium yoelii Signaling
Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium bergheiArticle Published on 2019-03-292024-08-28 Journal: Brain stimulation [Category] 말라리아, [키워드] 2-phospho-L-lactate 2-phosphoglycolate 4-phosphoerythronate gene knockout Glycolysis malaria Metabolic regulation phosphatase phosphoglycolate phosphatase (PGP) Plasmodium berghei protozoan.