Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance insulin resistance. intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology
Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium인간기도 상피에서 SARS-COV-2 유도 유전자 시그니처의 통합 메타 분석에 기초한 COVID-19에 대한 약물 용도Research Article Published on 2021-09-282022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 치료제, [키워드] activated acute respiratory syndrome Algorithm Algorithms ALPL Anti-viral approved Biomarker candidate canonical CCL20 CLC clinical trial clinical trials coronavirus coronavirus 2 COVID-19 COVID-19 pathogenesis COVID-19 treatment CSF3 CXCL1 CXCL10 CXCL8 database differentially expressed gene drug Drug repurposing drug target drugs effective intervention epithelial cells FDA gene network gene networks gene signature Genomics Human airway epithelium IL6 independent indications Infection inflammatory pathways information Ingenuity Pathway Analysis inhibit IPA list log2FC Meta-analysis pathway primary human airway Primary human airway epithelial cells Protein Qiagen regulate respiratory RNA sequencing SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severe acute respiratory syndrome-related coronavirus 2 target targets Treatment Trial [DOI] 10.1371/journal.pone.0257784 PMC 바로가기 [Article Type] Research Article
Estimates of gene ensemble noise highlight critical pathways and predict disease severity in H1N1, COVID-19 and mortality in sepsis patients유전자 앙상블 노이즈 추정치는 중요한 경로를 강조하고 H1N1, COVID-19의 질병 중증도 및 패혈증 환자의 사망률 예측Article Published on 2021-05-242022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] alteration among others Analysis approach bioinformatics biological pathway Biomarker calculated changes Clinical outcome clinical outcomes Complex I COVID-19 Critical Differential gene expression differential gene expression analysis disease disease severity disease-associated dissect estimate expression of gene finding Gene Expression Gene expression analysis gene network gene networks genes encoding H1N1 hallmark heterogeneous highlight immune include individual inter-individual Interpretation measure mitochondrial molecular molecular mechanism molecular mechanisms Mortality oxidative stress pathology pathway Pathways Patient patients peroxisomes predict Predictive markers Prism Prognostic markers protein complex protein complexes reflected respiratory chain Respiratory system models response Sepsis sepsis patient sepsis patients subunit subunits Variability variance [DOI] 10.1038/s41598-021-90192-9 PMC 바로가기 [Article Type] Article
KnetMiner: a comprehensive approach for supporting evidence‐based gene discovery and complex trait analysis across speciesResearch Article Published on 2021-04-052022-10-29 Journal: Plant Biotechnology Journal [Category] Coronavirus, MERS, SARS, [키워드] accelerate adopted Algorithm Analysis applied approach approach approaches Arabidopsis thaliana bioinformatics candidate gene candidate gene prioritization complex COVID‐19 Data integration database disease example exploratory data mining feature fungal gene discovery gene network gene networks generate Genes hypothese Information visualization insect knowledge Knowledge discovery Knowledge graph organization platform QTL Research researchers Support Systems biology Triticum [DOI] 10.1111/pbi.13583 PMC 바로가기 [Article Type] Research Article
Determining crucial genes associated with COVID-19 based on COPD Findings ✶,✶✶COPD 결과를 기반으로 COVID-19와 관련된 중요 유전자 결정 ✶,✶✶Article Published on 2021-01-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] analyzed CCR1 CD40LG cellular COPD COVID-19 COVID-19 virus dataset detect Determining disease FASLG finding function gene network gene networks GeneCard group ICAM1 immune system information IRF7 JUN LIFR MAPK8 MERS MOST NFkB1 NFKBIA organs pathway Patient patients POLD4 respiratory organs RPA2 SARS. severe COVID-19 STAT2 susceptible the disease this system virus viruses was used with COVID-19 [DOI] 10.1016/j.compbiomed.2020.104126 PMC 바로가기 [Article Type] Article
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver diseaseArticle Published on 2020-01-012023-06-12 Journal: Archives of Toxicology [Category] B형 간염, [키워드] gene networks Liver injury regeneration transcriptomics. [DOI] 10.1007/s00204-019-02630-3 PMC 바로가기
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system박테리아 단백질 글리코실화 시스템에서 속 수준 글리칸 다양성의 유전적 결정인자Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Bacteria Bacterial bacterial pathogen bacterial species bacterial specy biosynthetic biosynthetic pathway biosynthetic pathways Comparative genomics component components conjunction conservation core genome determine driven by effort event Evolution Express expressed functional gene networks Genes Genetic genetic determinant genetic difference genetic interactions genus glycosylation Host Human human disease human pathogen identify independent influence instance instances Interaction involved isolate isolates loss-of-function Neisseria gonorrhoeae Neisseria meningitidis oligosaccharide oligosaccharides Pathogens pathway Pathways Perspective phylogenetically polymorphism post-translational modification Protein Recombination required robust selective status subset sugar sugars unique [DOI] 10.1371/journal.pgen.1008532 PMC 바로가기 [Article Type] Research Article
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article