Genetic predisposition to milder forms of COVID-19 may provide some resilience to head and neck cancersOncology Original Research Published on 2024-07-082024-09-05 Journal: Frontiers in Oncology [Category] update2024, [키워드] causal relationship COVID-19 genetic factors head and neck cancer mendelian randomization [DOI] 10.3389/fonc.2024.1384061 PMC 바로가기 [Article Type] Oncology Original Research
Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic ApproachesReview Published on 2024-02-212024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] atherosclerotic plaque coagulation cascade Extracellular vesicles genetic factors Inflammation platelet–endothelial interaction Platelets Therapies thrombosis [DOI] 10.3390/ijms25052523 PMC 바로가기 [Article Type] Review
Genetic predispositions to psychiatric disorders and the risk of COVID-19정신 질환에 대한 유전적 소인과 COVID-19의 위험Article Published on 2022-08-232022-09-11 Journal: BMC Medicine [Category] 변종, [키워드] 95% CI 95% confidence interval adjusted odds ratio analyses Analysis Anxiety ascertainment association calculated coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic dataset death death records Depression disorder disorders examined Factor Genetic genetic factors Genetic predisposition genetic risk Genetic variant Genome-wide association study GWAS GWAS summary statistics hospital Hospitalization increased risk individual Logistic regression participant performed phenotype phenotypic predisposition PRS Psychiatric psychiatric disorder Psychiatric disorders Psychiatric disorders. psychotic disorder Public Health England Randomly repeated risk risk of COVID-19 selected severe cases severe COVID-19 stress-related disorders study population Surveillance UK biobank vulnerable population were used [DOI] 10.1186/s12916-022-02520-z PMC 바로가기 [Article Type] Article
Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19에스트로겐 호르몬은 COVID-19에서 염증과 면역 반응을 억제하는 필수 성 인자입니다Article Published on 2022-06-082022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제, [키워드] age approved caused COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 treatment death drug effective ESR1 ESR2 estradiol estriol Estrogen Estrogens estrone evaluated Factor Fatality rate female Genetic genetic factors Host host cells immune response increase indicated infected with SARS-CoV-2 Inflammation inhibit SARS-CoV-2 inhibiting lack male mechanism medication medications men Mortality mortality rate network analysis proportion PROTECT receptors reduce SARS-COV-2 infection Sex Signaling signaling pathway signaling pathways significantly synergistic target targets Treatment unique Vaccine with COVID-19 women [DOI] 10.1038/s41598-022-13585-4 PMC 바로가기 [Article Type] Article
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphismAPOE rs7412 다형성에 의한 SARS-CoV-2 감염에 대한 잠재적 보호 효과Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] age allele anthropometry ApoE association caused characterized Clinical outcome concerning coronavirus correction Course COVID-19 COVID-19 infection environmental factor Factor Genetic genetic determinant genetic factors Genetic variant genotyped global public health global public health emergency Increasing Infection Inflammation men metabolism multiple comparisons obesity pandemic polymorphism Potential priority protective effect resulting SARS-CoV-2 coronavirus SARS-COV-2 infection severity severity of COVID-19 statistically significant the SARS-CoV-2 Volunteer women [DOI] 10.1038/s41598-022-10923-4 PMC 바로가기 [Article Type] Article
Human phospho-signaling networks of SARS-CoV-2 infection are rewired by population genetic variantsSARS-CoV-2 감염의 인간 phospho-signaling 네트워크는 인구 유전 변이에 의해 재배선됩니다Article Published on 2022-05-012022-09-11 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] alterations Amino acid amino acid substitution amino acid substitutions Analysis ARFGEF2 association Comorbidities contributing to COVID-19 COVID-19 pathology disrupt Evolution Factor Genetic genetic factors Genetic variant Genetic variation Glucose highlight homeostasis Hospitalization Host host defenses host responses Human human genetic variation identify immune responses in viral induce Infection innate immune responses Inter-individual variation interferon interferon response involved kinase leads life cycle MAPK Missense modulated motif motifs nucleotide pathology Pathways phosphorylation site phosphorylation sites protein-protein interaction RNA splicing SARS-CoV-2 SARS-COV-2 infection sequence Sequence motifs severe COVID-19 Signaling signaling pathway signaling pathways Single nucleotide variant SNV SNVs STARD13 TANK TBC1D4 TBK1 translational TRIM28 Viral viral life cycle Viral proteins with COVID-19 [DOI] 10.15252/msb.202110823 PMC 바로가기 [Article Type] Article
A genetic variant in IL-6 lowering its expression is protective for critical patients with COVID-19발현을 낮추는 IL-6의 유전적 변이는 COVID-19에 걸린 중요한 환자를 보호합니다Article Published on 2022-04-022022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis association Asymptomatic COVID-19 changes in Chinese Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical critical condition expression Factor Formal G allele Genetic genetic factors Genetic variant Genome-wide association study genome-wide significance genome-wide significant Genotype healthy control healthy controls high mortality identify IL-6 IL-6 expression in vitro involved luciferase luciferase expression male Patient patients with asymptomatic patients with COVID-19 performed PROTECT Protective recruited replicated reported responsible serum significantly surpassed threshold variant Variation with COVID-19 [DOI] 10.1038/s41392-022-00923-1 PMC 바로가기 [Article Type] Article
Relapsed and newly diagnosed Graves’ disease due to immunization against COVID-19: A case series and review of the literature코로나19 예방접종으로 인한 그레이브스병 재발 및 새로 진단: 사례 시리즈 및 문헌 고찰Review Published on 2022-04-012022-09-11 Journal: Journal of autoimmunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant adjuvants age Autoimmune Autoimmune thyroid diseases case sery causal relationship coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine cross-reactivity develop diagnosed disease environmental factor environmental factors Factors female Genetic genetic factors grave Graves' disease Hashimoto Hashimoto's thyroiditis Hyperthyroidism immunization inactivated Inactivated COVID-19 vaccine Infection literature review mammalian protein manifestation mechanism mechanisms median median age molecular mRNA mRNA vaccine multicenter one patient Patient Prospective Study reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity symptom onset the median the patient the vaccine thought Thyroid Thyroiditis Trigger triggers viral particle Viral particles virus [DOI] 10.1016/j.jaut.2022.102809 PMC 바로가기 [Article Type] Review
Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19IL17의 유전적 연관성과 코로나19에 대한 타액 내 ABO 혈액형 항원의 중요성Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] ABO Activation Analysis Antigen association Blood Group carried caused conducted COVID-19 COVID-19 patient determine Factor FOXP4 FOXP4-AS1 FUT2 General population Genetic genetic association genetic factors genetics genome-wide association Genome-wide association study Genomic analysis Genotype GWAS identify IFNAR2 IL17 IL17A IL17F individual infection with SARS-CoV-2 innate immune response International involved Japan Japanese Meta-analysis mRNA expression nine outbreak Patient presenting replicated reported Respiratory failure risk allele Risk factors Saliva SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severity severity of COVID-19 significantly significantly lower SNP virus worldwide pandemic [DOI] 10.1038/s41598-022-07856-3 PMC 바로가기 [Article Type] Article
Exploring the ethics of genetic prioritisation for COVID-19 vaccinesCOVID-19 백신에 대한 유전적 우선순위의 윤리 탐구Review Published on 2022-03-072022-09-10 Journal: European Journal of Human Genetics [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] COVID-19 COVID-19 infection COVID-19 vaccine disease Ethics evaluate Evidence Factor Genetic genetic factors genetic marker Genetic markers genomic Health policy Host individual Infection resistance to infection response variability Spread vaccination Vaccine Variability vulnerability [DOI] 10.1038/s41431-022-01058-1 PMC 바로가기 [Article Type] Review