Analysis of genetic biomarkers, polymorphisms in ADME-related genes and their impact on pharmacotherapy for prostate cancerarticle Published on 2023-10-192024-09-05 Journal: Cancer Cell International [Category] update2024, [키워드] Androgen metabolism Biomarkers Genetic polymorphism pharmacotherapy Prostate cancer SNPs [DOI] 10.1186/s12935-023-03084-5 PMC 바로가기 [Article Type] article
Genetic polymorphism of the thrombospondin-related apical merozoite protein (TRAMP) of Plasmodium knowlesi in Malaysiaarticle Published on 2023-01-312024-09-01 Journal: Parasitology Research [Category] 말라리아, [키워드] Genetic polymorphism haplotypes Plasmodium knowlesi Thrombospondin-related apical merozoite protein [Article Type] article
Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 OutcomesHealth Archive Published on 2023-01-202024-09-05 Journal: British journal of biomedical science [Category] update2024, [키워드] COVID-19 outcomes Genetic polymorphism HLA IFNλ4 Prognostic markers [DOI] 10.3389/bjbs.2023.11044 PMC 바로가기 [Article Type] Health Archive
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations Meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
In vitro susceptibility profile of Plasmodium falciparum clinical isolates from Ghana to antimalarial drugs and polymorphisms in resistance markersarticle Published on 2022-10-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] drug resistance Genetic polymorphism In vitro assay malaria parasite ring survival assay West Africa [Article Type] article
From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22Article Published on 2022-10-212022-11-15 Journal: Cardiovascular Research [Category] 바이오마커, 유전자 메커니즘, [키워드] Anti-viral therapy approaches Atherosclerosis basic Basic science Biomarker Biomarkers Cardiac arrhythmia Cardiology cardiovascular cardiovascular system Cell Community Council COVID-19 demonstrated disease driving European extracellular vesicle Genetic polymorphism highlight Inflammation knowledge mechanism Medicine molecular molecular basis non-coding RNA pathogenic Personalized medicine Physiology Precision precision medicine Prize PROTECT Protective responses Science single-cell Society syndrome thrombotic complication Vascular [DOI] 10.1093/cvr/cvac114 PMC 바로가기
Genetic Sequence Variation in the Plasmodium falciparum Histidine-Rich Protein 2 Gene from Field Isolates in Tanzania: Impact on Malaria Rapid DiagnosisArticle Published on 2022-09-132024-08-29 Journal: Genes [Category] 말라리아, [키워드] amino acid repeats Genetic polymorphism Malaria diagnosis PfHRP2 Plasmodium falciparum sequence variation
Important roles of transporters in the pharmacokinetics of anti-viral nucleoside/nucleotide analogsArticle Published on 2022-09-132024-09-04 Journal: Expert opinion on drug metabolism & toxicology [Category] 대상포진, [키워드] Antiviral agents drug transporter drug-drug interaction Genetic polymorphism nucleoside/nucleotide analogs pharmacokinetics [DOI] 10.1080/17425255.2022.2112175 PMC 바로가기 [Article Type] Article
Association of single nucleotide polymorphisms in immune-related genes with spontaneous HBsAg seroconversion: A systematic review and meta-analysisReview Published on 2022-09-012023-06-12 Journal: International immunopharmacology [Category] B형 간염, [키워드] Genetic polymorphism Hepatitis B virus Meta-analysis Seroconversion systematic review [DOI] 10.1016/j.intimp.2022.108982 [Article Type] Review
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into CellsArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral surface virus virus entry virus infection viruses were infected wild-type [DOI] 10.1128/spectrum.00870-22 PMC 바로가기