Polymorphisms in the human angiotensin converting enzyme gene (ACE) linked to susceptibility of COVID-19 and malaria infections in the Ghanaian populationarticle Published on 2024-04-302024-09-01 Journal: Infection, Genetics and Evolution [Category] 말라리아, [키워드] ACE ACE2 angiotensin converting enzyme genetic polymorphisms Ghana [Article Type] article
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacyReview Published on 2023-11-132024-09-05 Journal: Inflammopharmacology [Category] update2024, [키워드] COVID-19 genetic polymorphisms Long COVID-19 metformin observational studies randomized clinical trials Vitamin D [DOI] 10.1007/s10787-023-01383-x PMC 바로가기 [Article Type] Review
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms and severe COVID-19: A protocol for systematic review and meta-analysisIFNL4, ACE1, PKR, IFNG, MBL2 유전적 다형성 및 중증 COVID-19: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-05-272022-09-11 Journal: Medicine [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] ACE-2 ACE1 angiotensin angiotensin-2 converting enzyme association caused Chinese Cochrane Handbook Cochrane Library Corona virus COVID-19 disease Effect English enzyme evaluated Evidence Genetic polymorphism genetic polymorphisms Google Scholar Handbook host cells IFNg IFNL4 include MBL2 Meta-analysis Methodological quality pathogenic peer-reviewed PKR Population progression PROSPERO protocol registration number researcher review SARS-CoV-2 severe COVID-19 submitted systematic review systematic reviews Virus Disease Web of Science [DOI] 10.1097/MD.0000000000029405 PMC 바로가기 [Article Type] Article
Genetic polymorphisms in genes associated with drug resistance in Plasmodium vivax parasites from northeastern Myanmar미얀마 북동부의 플라스모디움 비박스 기생충에서 약물 저항성과 관련된 유전자의 유전적 다형성Research Published on 2022-03-032024-08-01 Journal: Malaria Journal [Category] 말라리아, [키워드] drug resistance genetic polymorphisms Northeastern Myanmar Plasmodium vivax [DOI] 10.1186/s12936-022-04084-y PMC 바로가기 [Article Type] Research
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictorsCOVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다Article Published on 2022-03-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 변종, 치료기술, [키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate Multisystem inflammatory syndrome network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19 [DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article
The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19레닌-안지오텐신 시스템: SARS-CoV-2-유도 COVID-19의 핵심 역할Review Published on 2021-11-172022-09-10 Journal: Molecules [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE-2 ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected age Ang II Ang II/AT1R axis angiotensin Angiotensin II Angiotensin-converting enzyme ARDS Asia AT1R balance blood pressure cardiovascular diseases cascade causative agent cellular receptor characterized Comorbidities Comorbidity complications coronavirus coronavirus disease Coronavirus disease 2019 correlation country COVID-19 Cytokine storm diabetes downregulation dual dysregulation effective electrolyte balance Europe Factor feature followed by Gender Genetic polymorphism genetic polymorphisms Health Organization higher risk Host host susceptibility factors human tissue Hypercoagulation individual Infection Interaction involved less lung Lungs mechanism morbidity Mortality Multiple organ damage organ damage organs other organs outcome overactivation pandemic pathogenicity pathology produced proinflammatory promote RAS RAS imbalance receptor renin–angiotensin system respiratory respiratory distress risk factor role SARS-CoV-2 severity spread to subsequent syndrome the disease type I underlying diseases Vaccine vasoconstriction Viral virus while WHO World Health Organization Wuhan Wuhan, China [DOI] 10.3390/molecules26226945 PMC 바로가기 [Article Type] Review
A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19CTCF 결합을 방해하는 인터루킨-6의 저생산 일배체형은 심각한 COVID-19를 예방합니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, [키워드] 95% confidence interval allele Analysis antisense Asia Asian bidirectional transcription carrier carriers Chinese conserved correlated COVID-19 COVID-19 patient COVID-19 severity CTCF defined Disease progression disturbance element Endemic enhancer expression functional genetic polymorphisms Genotype Haplotype Human humans hyperinflammation IL-6 IL-6 blockade IL-6 expression induce Inflammatory responses inflammatory stimuli interleukin-6 intronic SNP intronic SNPs loci locus long noncoding RNA lower risk Mild Neanderthal Odds ratio outcome patients polymorphism Polymorphisms promoter Protective Quantitative reduced severe symptom severe symptoms severity significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs T allele therapy transcribed Variability variant Viral viral infection with COVID-19 [DOI] 10.1128/mBio.01372-21 PMC 바로가기 [Article Type] Research Article
Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals인간과 동물의 SARS-CoV-2 변이체의 푸린 절단 부위에 대한 진화론적 통찰력Article Published on 2021-09-012022-09-11 Journal: Archives of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Affect Alter Amino acid Analysis analyzed B.1.1.7 B.1.1.7 isolate B.1.351 B.1.429 B.1.429 + B.1.427 B.1.525 binding cell tropism circulating variants cleavage database Deletion deletions Effect eight except for FCS Frequency furin furin cleavage site genetic polymorphisms GISAID GISAID initiative Human initiative investigated isolates Laboratory motif Multiple Mutation mutations P.1 P681H pathogenicity Point mutation predicted prevalent Q677H SARS-CoV-2 spike protein SARS-CoV-2 variant sequence Seven shown significantly spike Spike protein Spike protein sequence Surveillance Transmissibility USA variant variants virus transmissibility [DOI] 10.1007/s00705-021-05166-z PMC 바로가기 [Article Type] Article
Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infectionSARS-CoV-2 감염에서 바이러스와 숙주 유전자 및 비코딩 RNA의 게놈 상호작용Review Published on 2021-09-012022-09-11 Journal: Immunobiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 age candidate Candidates Comorbidities contributed COVID-19 COVID-19 pathogenesis described Factor Genes genetic polymorphisms Genetic variant Genome Genome interaction genomes groups highlight Host host gene host genome Infection Interaction involved knowledge lncRNA mechanism miRNA molecular ncRNA non-coding RNA Pathogenesis Pathways Patient populations Regulatory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 virus Sequence analysis severity signaling pathway signaling pathways significantly SNPs SNPs, ncRNA, miRNA, lncRNA. susceptibility target gene Target genes the disease the patient TMPRSS2 Treatment strategies treatment strategy viral infectious diseases virus virus infection [DOI] 10.1016/j.imbio.2021.152130 PMC 바로가기 [Article Type] Review