Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Detection of New H5N1 High Pathogenicity Avian Influenza Viruses in Winter 2021-2022 in the Far East, Which Are Genetically Close to Those in EuropeArticle Published on 2022-09-302023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] Bird migration genetic profile H5N1 high pathogenicity avian influenza wild birds [DOI] 10.3390/v14102168 PMC 바로가기
Unraveling the hurdles of a large COVID-19 epidemiological investigation by viral genomics바이러스 유전체학으로 대규모 COVID-19 역학 조사의 장애물 풀기Article Published on 2022-07-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] assigned caused Community Concordance contribute COVID-19 COVID-19 case detect disease outbreaks Epidemics epidemiological Epidemiological investigation epidemiologically extension Genetic genetic profile genomic data Genomics Health authority healthcare information initial Local misidentification nursing home outbreak Portugal profiles Public public health public health authorities Region respiratory virus SARS-CoV-2 sensitivity Spread Still the disease Transmission Transmission dynamics triggered [DOI] 10.1016/j.jinf.2022.05.013 PMC 바로가기 [Article Type] Article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical SiblingsImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] 10x Analysis approach BNT162b2 Cell cellular chimerism clinical trial Combined COVID - 19 declining disease Donor dose Europe feasible female genetic profile hematopoietic Hematopoietic stem cell Hematopoietic stem cell transplantation (HSCT) humoral immune responsiveness Immunity immunocompetence immunological tolerance immunology Immunosuppression induce induction induction of tolerance Infection kidney Kidney transplantation lymphoid male Microscope molecular monotherapy mRNA vaccine occurred pandemic Patient patients previous study protocol Quality of life rejection sibling Specific Stanford STEM Stem cell transplantation steroid T cell the SARS-CoV-2 Tolerance transplantation was performed [DOI] 10.3389/fimmu.2022.796456 PMC 바로가기 [Article Type] Immunology
A Brazilian Inter-Hospital Candidemia Outbreak Caused by Fluconazole-Resistant Candida parapsilosis in the COVID-19 EraCommunication Published on 2022-01-202022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] Candida parapsilosis ERG11 mutations antifungal agents azole-resistant bloodstream Brazil Cancer Cancer center Candida parapsilosis Candidemia caused clonal outbreak Contamination contributed COVID-19 COVID-19 case COVID-19 pandemic drug resistance mechanisms genetic profile Genotype genotyping healthcare highlighting horizontal transmission hospital hygiene ICU patient incidence inter-hospital transmission isolate microsatellite typing Mutation Occurrence outbreak reported responsible SARS-CoV-2 sequence sequenced submitted susceptibility Transmission [DOI] 10.3390/jof8020100 PMC 바로가기 [Article Type] Communication
The Development of SARS-CoV-2 Variants: The Gene Makes the DiseaseReview Published on 2021-12-152022-10-29 Journal: Journal of Developmental Biology [Category] COVID-19, [키워드] accumulated mutation Affect affected Alpha variant antigenicity Beta caused characteristic concerning Contact COVID-19 COVID-19 vaccines D614G defined Deleterious delta variant described determine development E484K Effectiveness escape mutation functions Gamma genetic profile Human immune defense Immune escape initial knowledge L452R Lineage morbidity and mortality MOST Mutation mutations N501Y neutralizing antibodies (NAbs) Novel coronavirus nucleocapsid occurred other variants P681R pandemic prevalent Protein receptor binding domain (RBD) SARS-CoV-2 SARS-CoV-2 genome scrutiny severe respiratory disease severity Spike protein Spread synonymous T478K the disease the SARS-CoV-2 the Spike the spike protein Transmissibility unique Vaccines variant variant of concern (VOC) Variation viral fitness virus virus genome virus variant [DOI] 10.3390/jdb9040058 PMC 바로가기 [Article Type] Review
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance프로테옴 전반에 걸친 유전자 조사는 임상 관련성이 있는 여러 SARS-CoV-2 악용 숙주 표적을 식별합니다.Research Article Published on 2021-08-172022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, [키워드] ABO Accepted Affect affecting age Alpha Analysis Antiviral Apoptosis applied approach arising association Author cause CD209 clinical trial contribute COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 phenotypes datasets DC-SIGN death Demographic factors demonstrated disease severity evade explain Factor Factors funding Gender gene expression level gene mutation Genetic genetic colocalization genetic profile healthy individuals help Host host cells host protein host proteins Human identify identifying IL-6R immune immune response individual individuals infect Infection interact Interaction involved Karim MAK mechanism Medical Research Council mendelian randomization minor symptom minor symptoms molecular mutate natural experiment new strain no symptom no symptoms OAS1 open Open Access opens Patient patients with COVID-19 pleiotropic Potential treatment precursor predict predicted Probability PROTECT Protein Proteins proteome provide randomisation reaction receptor receptor protein reduce Research response responsible risk SARS-CoV-2 severe COVID-19 severity of COVID-19 SIGN Spike protein Strains submission susceptibility susceptible susceptible hosts Symptoms target targets the spike protein the strongest Therapeutics treat Treatment Trigger unique unit variety virus virus strains viruses Wellcome Trust with COVID-19 [DOI] 10.7554/eLife.69719 PMC 바로가기 [Article Type] Research Article
Comparative Genomics Reveals Early Emergence and Biased Spatiotemporal Distribution of SARS-CoV-2비교 유전체학은 SARS-CoV-2의 조기 출현 및 편향된 시공간 분포를 나타냅니다Discoveries Published on 2021-06-192022-09-10 Journal: Molecular Biology and Evolution [Category] SARS, 변종, 유전자 메커니즘, [키워드] 3′-UTR absence Analysis approach approaches changes in China circulation classification Clinical characteristics Clusters Comparative Comparative genomics complement conserved contributing to convergent evolution COVID 19 Defense distribution driven by early emergence emergence epidemiological epidemiological studies Epidemiological study Evidence evidence of Evolution exhibiting facilitate fixation functional genetic profile Genetic variant genetic variants Genome sequences genomes genomic Genomic surveillance Genomic variability Genomics Geographic distribution highlight human pathogen independent Infectious disease Infectious diseases isolates Isolation Metadata molecular data open outbreak outlined pandemic pathogen Pathogens phenotypic feature Phylogenetic polymorphic site positive predicted question sampling SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates secondary structure Seven spatiotemporal Spread Strains substitutions Surveillance unlikely UTR UTRs Validity Variability variant Viral viral genome viral strains virus widespread [DOI] 10.1093/molbev/msab049 PMC 바로가기 [Article Type] Discoveries
Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultryResearch Article Published on 2017-05-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Analysis bronchitis can be used conducted determine diagnostic epidemiological full-length Genetic genetic distribution genetic profile group Hypothesis IBV identify Infectious Bronchitis Virus isolate isolates mass Massachusett Mutation mutations network analysis persistence Phylogenetic Population Positive selection predominant Selection sequence strain subpopulation Support trajectory Vaccine virus viruses [DOI] 10.1371/journal.pone.0176709 PMC 바로가기 [Article Type] Research Article