Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinomaArticle Published on 2021-09-012023-06-11 Journal: Molecular carcinogenesis [Category] B형 간염, [키워드] gene-environment interaction genetic risk score HBV-related hepatocellular carcinoma INTS10 single-nucleotide polymorphism [DOI] 10.1002/mc.23328
Genetic risk for severe COVID‐19 correlates with lower inflammatory marker levels in a SARS‐CoV‐2‐negative cohortOriginal Article Published on 2021-06-062022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immune response Affect age Alpha applied association baseline baseline level Blood Blood level body mass index Cohort coronavirus coronavirus disease COVID‐19 COVID‐19 patients COVID‐19 cytokine Effect electrochemiluminescence method endothelial explain genetic risk genetic risk score genotype data growth factor hypothesise IFN‐γ IFN‐γ increasingly individual Infection Inflammation Inflammatory Inflammatory marker inflammatory markers inflammatory protein Innate immunity interferon gamma marker Necrosis obesity objective overactive profile reduced Result risk SARS‐CoV‐2 SARS‐CoV‐2 serum Support susceptibility susceptible the cytokine storm TNF‐α TNF‐α variable Vascular [DOI] 10.1002/cti2.1292 PMC 바로가기 [Article Type] Original Article
Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection심각한 SARS-CoV-2 감염 위험과 혈청 HDL-콜레스테롤 및 아포지단백 A1 수치의 연관성Multicenter Study Published on 2021-03-022022-09-10 Journal: Journal of Lipid Research [Category] 바이오마커, 변종, [키워드] 95% CI, 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele alleles ApoA1, apolipoprotein A1 APOE4 apolipoprotein A1 association Biomarker CAD, coronary artery disease cholesterol clinical risk factor Clinical risk factors Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19, Coronavirus disease 2019 cumulative cumulative effects diabetes Effect elevated evaluated Evidence feature genetic risk score Genetic variant genetic variants GRS, genetic risk scores HDL-cholesterol higher risk homozygous hypertension ICD-10, International Classification of Diseases, Tenth Revision increase in individual Infection investigated Logistic regression analyses Logistic regression analysis mendelian randomization Mendelian randomization analyses Mendelian randomization analysis metabolic syndrome Mortality MR, Mendelian randomization MVMR, multivariate MR negative controls Novel coronavirus obesity OR, odds ratio outcomes PC, principal component reduced risk respiratory Respiratory disease risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 serum serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection severe respiratory disease severe SARS-CoV-2 severity of COVID-19 Sex susceptible syndrome type 2 diabetes UK biobank were used [DOI] 10.1016/j.jlr.2021.100061 PMC 바로가기 [Article Type] Multicenter Study
Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study유전적 비만, 심혈관 대사 프로필 및 COVID-19 감수성에 대한 인과 추론: 멘델식 무작위 배정 연구Genetics Published on 2020-11-112022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association BMI body mass body mass index cardiometabolic cardiometabolic trait cardiometabolic traits category Causal cholesterol co-morbidity Cohort conducted confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 Host Genetics Initiative COVID-19 infection Cox model Cox proportional hazard models European evaluate Genetic genetic risk genetic risk score genetic risk scores Genotype Glucose glycated hemoglobin hazard ratio HDL-cholesterol hemoglobin high-density High-density lipoprotein higher odd higher odds Hospitalization host genetics increased risk independent dataset independent datasets indicated individual Inference integration LDL LDL cholesterol lipid profile lipoprotein low-density Low-density lipoprotein mendelian randomization Modification morbidities MR analysis multivariable logistic regression obesity observational studies observational study Odds ratio parameter participant phenotype positive predictor present produced profile Quantitative reported respiratory Result risk Risk assessment risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity serum severe acute respiratory syndrome Coronavirus Standard deviation Support susceptibility Systolic blood pressure tested traits Treatment Triglyceride triglycerides UK biobank Waist circumference was performed [DOI] 10.3389/fgene.2020.586308 PMC 바로가기 [Article Type] Genetics
Evaluation of a genetic risk score for severity of COVID-19 using human chromosomal-scale length variationPrimary Research Published on 2020-10-092022-10-31 Journal: Human Genomics [Category] COVID-19, MERS, SARS, [키워드] Algorithm Asymptomatic AUC autosomes build classification algorithm Classifier clinically Course COVID-19 dataset develop DNA evaluated expected Genetic genetic risk score Genetic variation machine learning Patient patients predict random Randomized responsible Result SARS-COV-2 infection severity severity of COVID-19 significant level Symptom UK biobank Variability Variation [DOI] 10.1186/s40246-020-00288-y PMC 바로가기 [Article Type] Primary Research
Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis – a phenome-wide association study and inverse-variance weighted meta-analysisArticle Published on 2020-06-132024-09-04 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] 대상포진, [키워드] genetic risk score Pleiotropy rheumatoid arthritis [DOI] 10.1002/art.41291 PMC 바로가기 [Article Type] Article
Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort완전 모유 수유는 유전적으로 민감한 어린이의 체질량 지수 증가를 약화시킬 수 있습니다. ALSPAC 코호트의 종단 연구Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI adiposity peak adiposity rebound Adolescence age allele ALSPAC Analysis attenuate Birth BMI Breastfeeding childhood children Cohort composed Critical decrease early childhood EBF evaluated exclusive breastfeeding explain Factors Genetic genetic factors genetic risk genetic risk score genetic variability Genetic variant genetic variants Genome-wide association study genome-wide significant growth GRS GWAS GWASs increase in influence Intervention large-scale genome-wide association studies life longitudinal longitudinal study modulating non-communicable diseases obesity overweight parent parents pediatric Predictive Previous studies previous study priority proportion quartile recent reduce reducing risk shown significantly SNP susceptible variant was used while [DOI] 10.1371/journal.pgen.1008790 PMC 바로가기 [Article Type] Research Article
Causal relationships between obesity and the leading causes of death in women and men비만과 여성과 남성의 주요 사망 원인 사이의 인과 관계Research Article Published on 2019-10-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect Analysis association blood pressure BMI body mass body mass index cardiometabolic disease cardiometabolic diseases causal relationship causal relationships cause Chronic kidney disease chronic liver disease chronic obstructive chronic obstructive pulmonary disease chronic renal failure Cochran’s Q-test Coronary artery Coronary artery disease death diabete diabetes Diabetes Mellitus disease disease risk downstream Effect etiological Fatty liver fatty liver disease genetic data genetic risk score genetic variants glycemic GRS heart disease higher risk implicated implication increase increased risk indicate instrumental variable instrumental variables investigated involved Kidney disease lung cancer majority mediators men men and women mendelian randomization Mortality Non-alcoholic fatty liver disease non-communicable diseases obesity obstructive pulmonary disease preventative measure public health pulmonary disease renal renal failure risk smoking Still stroke traits type 2 diabete type 2 diabetes UK biobank waist waist-hip ratio Waist-hip-ratio WHR women [DOI] 10.1371/journal.pgen.1008405 PMC 바로가기 [Article Type] Research Article
Genetic association of complement component 2 variants with chronic hepatitis B in a Korean populationArticle Published on 2018-09-012023-06-19 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] Chronic Hepatitis B complement component 2 genetic risk score Single nucleotide polymorphism [DOI] 10.1111/liv.13675
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study자궁 경부 종양에 대한 유전적 감수성 정의 - 전체 게놈 연관 연구Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele amino-acid Antigen approaches association biological basis Cancer cancer development carried cervical cancer Combination complex correlation demonstrated determine determined by DRB1 error foundation Future Genetic genetic loci genetic risk genetic risk score genetic risk scores genetic susceptibility Genetic variant genetic variants Genome-wide association study healthy controls highest HLA HLA alleles HLA haplotype HLA-B HLA-DRB1 host genetics HPV human leukocyte antigen human papillomavirus identify immune immune-related protein immune-related proteins include increased risk indicated Infection inheritance involved leukocyte major histocompatibility complex MHC MHC alleles neoplasia performed pocket Previous studies previous study Prognosis progression Protective residue risk risk factor Risk factors screening methods standard error statistical the major histocompatibility to define Treatment variant women [DOI] 10.1371/journal.pgen.1006866 PMC 바로가기 [Article Type] Research Article