Spike-heparan sulfate interactions in SARS-CoV-2 infectionArticle Published on 2022-10-012022-11-16 Journal: Current opinion in structural biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding binding biochemical cellular Evolution genetic study glycan highlight Host host cell Infection Interaction potential therapy provide recent required SARS-CoV-2 SARS-COV-2 infection shown Spike protein Spread subsequent the SARS-CoV-2 the spike protein variants [DOI] 10.1016/j.sbi.2022.102439 PMC 바로가기
TNFRSF1B and TNF Variants Are Associated With Differences in Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Severe COVID-19Article Published on 2022-09-132022-11-16 Journal: The Journal of Infectious Diseases [Category] 변종, [키워드] association coronavirus disease COVID-19 COVID-19 severity determine difference ELISA evaluated exhibited expression Factor genetic study Genetic variant genetic variants genetics Genotype genotypes implicated IMV Invasive mechanical ventilation Level no difference paO2/fiO2 Patient patients patients with COVID-19 plasma plasma sample receptor severe COVID-19 severity TNF TNF-α TNFR1 TNFR2 TNFRSF1A TNFRSF1B Tumor tumor necrosis factor-α variant was used were used with COVID-19 [DOI] 10.1093/infdis/jiac101 PMC 바로가기
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 Research Published on 2022-08-152022-10-05 Journal: Nature Communications [Category] SARS, 바이오마커, 신약개발, 유전자 메커니즘, 임상, 치료법, [키워드] ACE2 alveolar association Cell cells COVID-19 COVID-19 infection eight ELF5 epithelial epithelial cell expressed Factor Factors Gene Expression Genetic genetic study higher risk highlight Host host response immunohistochemistry initiative outcome plasma plasma proteomics predicted Prognosis protein mediator RAB2A Research Respiratory system risk robust SARS-CoV-2 severe COVID-19 single-cell Single-cell RNA sequencing statistical target TMPRSS2 transcription factor [DOI] 10.1038/s41467-022-31999-6 [Article Type] Research
Knowledge gaps and national research priorities for COVID-19 in IranResearch Published on 2022-03-022022-10-31 Journal: Health Research Policy and Systems [Category] Coronavirus, MERS, SARS, [키워드] Analysis approach approved challenges Characteristics Clinical management consequence country COVID-19 COVID-19 crisis COVID-19 epidemic COVID-19 research Diagnosis dissemination domain Efficiency epidemiological Epidemiology equity genetic study Health Health systems research hygiene identify implementation International international organization Iran knowledge Knowledge need literature review Local manifestation mapped media National performed professionals public health question raised recommendations Research research priority Research priority-setting Research question researcher resources respond Result risk factor supplementary material Topic Transmission Treatment Vaccine virus [DOI] 10.1186/s12961-021-00805-y PMC 바로가기 [Article Type] Research
New insights into human immunity from ancient genomics고대 유전체학에서 인간 면역에 대한 새로운 통찰력Review Published on 2021-10-012022-09-11 Journal: Current opinion in immunology [Category] SARS, 유전자 메커니즘, [키워드] admixture analyses COVID-19 disease Defense Diseases DNA Epidemics Evolution form function functions Genetic studies genetic study Host host defense Human human immunity human populations humans hybridization immune immune gene immune genes immune response Immunity indicated infectious agents natural selection Neanderthal New Pathogens Population reported Sequencing severe COVID-19 disease subject susceptibility Variation [DOI] 10.1016/j.coi.2021.04.006 PMC 바로가기 [Article Type] Review
A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severityResearch article Published on 2021-10-012022-10-05 Journal: iScience [Category] 변종, 유전자 메커니즘, [키워드] Analysis association Biological sciences caused Chinese cholesterol clinical assessment comprehensive analysis contribute COVID-19 diagnosis COVID-19 pandemic COVID-19 severity current death disease disease severity explain functional gene gene-based analysis Genetic genetic mechanism genetic study genetics GSEA GWAS Host IFN Infection Innate immunity interferon Laboratory mendelian randomization MHC complex MR study Pathways Patient Receptor binding risk factor SARS Coronavirus traits Treatment type I interferon Virology WBC [DOI] 10.1016/j.isci.2021.103186 [Article Type] Research article
Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility증상 기반 사례 예측을 사용하여 COVID-19 감수성에 기여하는 숙주 유전자 요인을 확인Research Article Published on 2021-08-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, [키워드] Analysis Cohort conducted contribute controls COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 susceptibility cross-sectional effort Factor Genetic genetic architecture genetic association genetic associations Genetic studies genetic study genetic susceptibility Genetic variant genetic variants genome-wide significance GWAS Host identify IMPROVE Inclusion independent observé overlap phenotype predict predicted pursuit reached SARS-COV-2 infection scenario severity of COVID-19 shown SNP susceptibility Symptoms the disease variant Viral viral infectious disease viral infectious diseases viral outbreak while with COVID-19 [DOI] 10.1371/journal.pone.0255402 PMC 바로가기 [Article Type] Research Article
High-throughput framework for genetic analyses of adverse drug reactions using electronic health records전자 건강 기록을 사용한 부작용 반응의 유전자 분석을위한 고 처리량 프레임 워크Research Article Published on 2021-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] added ADR ADRS Adverse drug reaction Adverse drug reactions Adverse reaction Adverse reactions allergy Analysis approach association associations Biobank clinical guideline Clinical guidelines common diseases conducted CYP2D6 develop DNA drug Drug allergy drug response Electronic health record Electronic health records eligible patient Eligible patients Evidence expression genetic association genetic associations genetic loci Genetic studies genetic study Genetic variation Genome-wide association studies Genome-wide association study group GWAS Healthcare system help identify IMPROVE individual less loci opioid OPRM1 pathophysiological mechanism pathophysiological mechanisms phenome physiological Precision proof Quantitative recorded Research response sample sizes understanding university [DOI] 10.1371/journal.pgen.1009593 PMC 바로가기 [Article Type] Research Article
Genetic variability in COVID-19-related genes in the Brazilian populationArticle Published on 2021-04-022022-10-04 Journal: Human Genome Variation [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project 1KGP ABO ACE2 ACE2 gene Affect allele frequency Analysis analyzed angiotensin-converting enzyme 2 Brazil Brazilian Brazilians candidate gene CCR9 Clinical prognosis contribute country COVID-19 COVID-19 case COVID-19 infection COVID-19 patients COVID-19 severity CTSL CXCR6 database disease DQB1 DRB1 examined Exome exomes explain FYCO1 gene sequence genetic background genetic study genetic variability Genetic variation Genome gnomAD help highest HLA allele Host host cells human lung cells identify IL6 Immunity implicated individual individual level infect Infection infection with SARS-CoV-2 Influenza virus information International investigated life-threatening loci LZTFL1 nonsynonymous Other Patient Phase 3 Pneumonia Population predicted previous study Protein Rare variants rate of infection recent receptor recorded reported risk SARS-CoV-2 SARS-COV-2 infection Seven shown SLC6A20 suggested susceptibility therapeutic targets TMPRSS2 transmembrane serine protease type I interferon unique university Variability variant Variation viral infection XCR1 [DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection인간의 일반적인 유전적 변이가 SARS-CoV-2 감염에 대한 시험관 내 감수성에 영향을 미침Article Published on 2021-03-092022-09-11 Journal: Stem Cell Reports [Category] SARS, 변종, [키워드] addition alveolar antibody repertoire Brain Cell clinical complications clinical heterogeneity common Comorbidities contribute COVID-19 COVID-19 pandemic CRISPR disease drugs etiologic agent facilitate furin FURIN rs4702 genetic study Genetic variant Genetic variation healthy individual healthy individuals help Host host genetics host response Human human induced pluripotent stem cell identify Impact in vitro individual individuals Infection influence males Neuron neurons polymorphism predict principle protease SARS-CoV-2 single-nucleotide single-nucleotide polymorphism stem cell UTR Variability viral infection Viral load [DOI] 10.1016/j.stemcr.2021.02.010 PMC 바로가기 [Article Type] Article