Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challengesReview article Published on 2022-02-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 비임상, [키워드] AAV approach caused clinical trial clinical trials component CRISPR CRISPR-Ca CRISPR-Cas delivery Diseases effective Gene therapy Genome genomic integration High dose highlight in vivo limitations Lipid nanoparticle liver LNP Mutagenesis overcome palindromic repeat Safe shown therapy Toxicity trend virus Virus-like particle VLP [DOI] 10.1016/j.jconrel.2022.01.013 [Article Type] Review article
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissuesParry et al.에 대한 응답: SARS-CoV-2 서열의 게놈 통합 및 환자 조직에서의 발현에 대한 강력한 증거Comment Published on 2021-08-172022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, [키워드] Evidence expression genomic integration Patient response SARS-CoV-2 sequence Strong tissue [DOI] 10.1073/pnas.2109497118 PMC 바로가기 [Article Type] Comment
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다Research Article Published on 2021-07-162022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic [DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues역전사된 SARS-CoV-2 RNA는 배양된 인간 세포의 게놈에 통합될 수 있으며 환자 유래 조직에서 발현될 수 있습니다.422 Published on 2021-05-252022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′ end absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 can not cellular chimeric chimeric RNAs clinical recovery Consensus contribute coronavirus COVID-19 Culture DNA duplication Evidence explain expressed fraction fusing Genome genomic integration help host cell human cell human cells Hypothesis in some infected cell Infection Infectious virus initial integration integration sites investigated LINE1 majority mechanism Patient patients PCR PCR-positive positive positive PCR test produced Prolonged recurrence reported respiratory reverse transcription RNA SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 sequences sequence severe acute respiratory syndrome Coronavirus Significance Support tissue tissues transcribed transcript Transcription transcripts Viral viral genome viral replication Viral RNA viral sequence viral sequences viral transcript viral transcripts [DOI] 10.1073/pnas.2105968118 PMC 바로가기 [Article Type] 422
Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs OutbreakEndocrinology Published on 2020-09-102022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, [키워드] ALAN anthropogenic artificial bat component Coronaviridae coronavirus coronavirus disease COVID-19 Endocrine feature functions genomic genomic integration HCoVs immune influence LIGHT majority melatonin mitigate Mutation Night nocturnal Occurrence organism outbreak pandemic physiological Potential Stress sustainability synchronization variable virus zoonotic [DOI] 10.3389/fendo.2020.00622 PMC 바로가기 [Article Type] Endocrinology
Fusion of HPV L1 into Shigella surface IcsA: A new approach in developing live attenuated Shigella-HPV vaccineHPV L1이 Shigella 표면 IcsA로 융합: 생약화된 Shigella-HPV 백신 개발의 새로운 접근법journal-article Published on 2014-02-012024-07-30 Journal: Antiviral research [Category] 세균성이질, [키워드] Autotransporter genomic integration human papillomavirus vaccine Shigella sonnei [DOI] 10.1016/j.antiviral.2013.12.003 [Article Type] journal-article