Mass Switch From Intravenous to Subcutaneous Tocilizumab in Rheumatic Diseases During the SARS-COV-2 PandemicArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] administration adverse event Analysis Cell COVID Critical disease effective Follow-up Giant giant cell arteritis headache hospital injection intravenous juvenile idiopathic arthritis mass pandemic Patient remained rheumatoid arthritis rheumatological patient rheumatology Safe Subcutaneous subgroup analysis switch switching Systemic sclerosis TCZ the SARS-CoV-2 Tocilizumab Treatment was performed [DOI] 10.1097/RHU.0000000000001862 PMC 바로가기
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessmentArticle Published on 2022-09-012022-11-16 Journal: Journal of Pharmacological and Toxicological Methods [Category] 신약개발, [키워드] Abstract Analysis Annual appear approach arising article assessments attrition automated clinical study COVID-19 drug effort FDA Giant global pandemic hERG. ICHE14/S7B in vitro in vivo manuscript Perspective Pharmacology Prevent problem protocol QT correction Regulatory Safety Safety assessment safety pharmacology Society SPS Taking Volume [DOI] 10.1016/j.vascn.2022.107206 PMC 바로가기
“Is Omicron mild”? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies"오미크론은 마일드한가"? 세 계보의 돌연변이 환경과 기존 백신 및 치료 항체에 대한 반응으로 이 내러티브 테스트Review Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody conserved convalescent COVID-19 infections Effectiveness Evolution Genome Giant immune immune evasion Immunity infections Lineage mild symptoms monoclonal Mutation narrative neutralization neutralization resistance Neutralizing antibodies neutralizing antibody omicron Omicron lineages Pathogenesis polyclonal Positive selection produced raised Receptor-binding domain reduction in Reinfection reported SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants shown Spike protein tested Testing the receptor-binding domain the spike protein therapeutic triggered Vaccine vaccine effectiveness (VE) Viral viral evolution viral evolution. virus infectivity [DOI] 10.1002/jmv.27749 PMC 바로가기 [Article Type] Review
Detailed videocapillaroscopic microvascular changes detectable in adult COVID-19 survivors성인 COVID-19 생존자에서 감지할 수 있는 상세한 비디오모세혈관경 미세혈관 변화Article Published on 2022-07-012022-09-11 Journal: Microvascular research [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] age Analysis Angiogenesis Capillaries capillary cause change CNT concerning concomitant therapies contrary control group control groups control subject control subjects controls COVID-19 detectable disease disease onset disease severity Effect endothelial cells Endothelial dysfunction evaluate Frequency Giant Glucocorticoids induce less linear Microcirculation Multivariate analysis Nailfold capillaroscopy no statistically significant difference organ damage parameter Patient raynaud s phenomenon Raynaud's phenomenon reduced SARS-CoV-2 SARS-CoV-2. scored searched selective significantly significantly lower statistically significant difference survivor Therapies therapy [DOI] 10.1016/j.mvr.2022.104361 PMC 바로가기 [Article Type] Article
Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case SeriesCOVID-19 백신 접종 후 심근내 염증: 심근내막 생검으로 입증된 사례 시리즈Article Published on 2022-06-222022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] administration analysis Analysis can not Cardiomyopathy Case report causal relationship cause CD4 CD8 Cell clinical suspicion Comirnaty connection COVID-19 COVID-19 vaccination criteria demonstrated Diagnosis Differential analysis dominance Ejection fraction EMB Endomyocardial biopsy epidemiological excluded expression of SARS-CoV-2 Giant giant cell giant cell myocarditis heart histopathological increased risk individual infectious Inflammatory inflammatory cardiomyopathy Inflammatory marker inflammatory markers Inflammatory response investigated janssen Johnson & Johnson LVEF male mRNA mRNA-based vaccines Myocardial inflammation myocarditis nine Occurrence Patient patients Pfizer-BioNTech reduced reported SARS-CoV-2 SARS-CoV-2 spike protein Sery Spike protein T cell T cells the vaccine triggered vaccination vaccination. Vaxzevria [DOI] 10.3390/ijms23136940 PMC 바로가기 [Article Type] Article
Mutation induced infection waves in diseases like COVID-19COVID-19와 같은 질병에서 돌연변이 유발 감염 파동Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] Coronavirus, 변종, 치료법, [키워드] caused competing contagious COVID-19 COVID-19 disease death decrease disease Diseases Evolution example Giant grain growth increasingly induce Infection Infectious disease Infectious diseases majority measure Mutation mutations occur outcomes positive feedback positive feedback loop predict reduce risk statistical statistical mechanics Strains tested vaccination wave train wave trains [DOI] 10.1038/s41598-022-13137-w PMC 바로가기 [Article Type] Article
Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats Research Published on 2022-05-142022-10-05 Journal: The ISME Journal [Category] 바이오마커, [키워드] adaptation aerobe Ailuropoda Amino acid Analysis Bacteria Bacteroidaceae Bacteroidale Bamboo circulating composed Concentration conducted Degradation elevated enzyme facultative Fatty acid fatty acid metabolism Giant Gut Host host gene expression Interaction mammal mechanism metabolite metabolome microbial Microbiome SCFAs serum significantly vitamins [DOI] 10.1038/s41396-022-01247-2 [Article Type] Research
Computer-designed repurposing of chemical wastes into drugs Research Published on 2022-04-272022-10-05 Journal: Nature [Category] 신약개발, [키워드] accelerate Algorithm analysis Comprehensive criteria Degradation drug experiment generate Giant hazards help knowledge Metrics reuse substrate tracing [DOI] 10.1038/s41586-022-04503-9 [Article Type] Research
Giant compressive emphysema: a rare complication of COVID-19Case Report Published on 2021-12-302022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antibiotic therapy association beta-coronavirus chronic obstructive Comorbidities complication of COVID-19 coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Critical CT scan curative described Diagnosis dose emphysema evaluate Giant had no Hospitalization Hospitalized ipsilateral lung lung involvement Manifestations oxygen Oxygen therapy Pain Patient Physical examination Pneumonia Prognosis pulmonary disease pulmonary involvement pulmonary parenchyma responsible RNA SARS-CoV-2 severity Structure subject the patient Thoracic Thoracic CT scan tympany was performed worldwide pandemic [DOI] 10.1186/s12879-021-07006-6 PMC 바로가기 [Article Type] Case Report
Community Intervention System: COVID-19 Control in Inner Mongolia Autonomous Region, ChinaArticle Published on 2021-12-062022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] autonomous caused Characteristics chi-square test China Combination Community Community intervention Control COVID-19 COVID-19 epidemic COVID-19 prevention Effectiveness event function Giant Guidance identify IMPROVE independent influence influences on Inner Mongolia inner mongolia autonomous region internal and external Intervention major public health events mechanism principal component analysis public health Region Research [DOI] 10.3390/ijerph182312857 PMC 바로가기 [Article Type] Article