Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key AreasReview Published on 2024-08-142024-09-05 Journal: Microorganisms [Category] update2024, [키워드] bacterial proteins Experimental vaccines extended-spectrum beta-lactamases (ESBLs) global healthcare immunology Microbiology NPSLE Tuberculosis [DOI] 10.3390/microorganisms12081672 PMC 바로가기 [Article Type] Review
Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crisesArticle Published on 2022-11-012022-11-16 Journal: Biophysical chemistry [Category] 신약개발, [키워드] affected Analysis approach Cheminformatics clinical clinical study clinical trials complex compounds COVID-19 COVID-19 pandemic COVID-19 therapeutics deep learning develop Disease progression drug Drug repurposing drugs effort global healthcare Health help identify in silico Infectious disease information Intervention lack limitation machine machine learning miRNA MONITOR New pandemic pharmacological strategy Regulatory Research robust Side-effects System Systems biology targets therapeutic therapeutic target Treatment strategies [DOI] 10.1016/j.bpc.2022.106891 PMC 바로가기
Targeting SARS-CoV-2 papain-like protease in the postvaccine eraArticle Published on 2022-11-012022-11-15 Journal: Trends in pharmacological sciences [Category] SARS, 치료제, [키워드] approval artificial intelligence Compound computer-aided drug design COVID-19 Critical direct-acting antiviral drug drugs expected global healthcare Host innate immune response methodology Papain-like protease PLPro Rapid responses SARS-CoV-2 SARS-CoV-2 protein Small molecules small molecules. targeting therapeutic target Vaccine viral replication waning immunity while [DOI] 10.1016/j.tips.2022.08.008 PMC 바로가기
SARS-CoV-2-on-Chip for Long COVID ManagementArticle Published on 2022-10-182022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome biosensors complex coronavirus coronavirus disease costly COVID diagnosis of SARS-CoV-2 diagnostic global healthcare Laboratory Long Long COVID management mortalities point-of-care polymerase chain progression public health emergency raised reduce representing resource reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2-on-chip time-consuming viral infection [DOI] 10.3390/bios12100890 PMC 바로가기
Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signalsReview article Published on 2022-10-012022-10-05 Journal: Sleep medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Activation addition adverse event Compliance Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Critical disease manifestation global healthcare Healthcare professional Hypothesis IL-1β Immunity IMPROVE INF-γ Inflammatory inflammatory signal inhibit innate immune system interactions knowledge mechanism morbidity and mortality Narcolepsy Neuron occur Orexin physiological pro-inflammatory cytokine reactogenic reactogenicity Regulation reported Research SARS-COV-2 infection Sickness Side effect Sleep Sleep disturbance Symptom TNF-α vaccination Vaccine while [DOI] 10.1016/j.sleep.2022.06.011 [Article Type] Review article
Inflammatory Biomarkers Associated with In-Hospital Mortality in Critical COVID-19 PatientsArticle Published on 2022-09-092022-11-15 Journal: International Journal of Molecular Sciences [Category] 바이오마커, [키워드] Analysis AST calculated Clinical course contribute COVID-19 COVID-19 pandemic creatinine Critical critical COVID-19 patients CRP cut-off demonstrated diagnosed with COVID-19 global healthcare groups healthcare identify IL-6 in-hospital mortality in-hospital mortality rate Inflammation Inflammatory biomarker inflammatory parameter INR Kaplan-Meier survival curve laboratory parameter marker Mortality non-survivor parameter Patient patients performed Predictive prognostic reducing retrospective risk stratification ROC significantly higher statistical analysis statistically significant statistically significant difference survival survivor thresholds urea WBC [DOI] 10.3390/ijms231810423 PMC 바로가기
A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] 1:1 28-day mortality addition Admission Admissions Analysis Appendix 1 benefit Care changes in chronic chronic condition chronic disease chronic liver disease cirrhosis clinical Clinical improvement Clinicians Cohort conducted COVID-19 COVID-19 pandemic criteria disease evaluated exploratory subgroup analysis feasibility generalisability generate global healthcare Health Health Service health team healthcare Healthcare systems heart failure hospitalisation implementation implication include Interdisciplinary health team. interim analysis Intervention intervention arm liver Liver disease Melbourne, Australia Mortality mortality risk New outcome participant Patient performed Prevalence Primary outcome Quality of life randomisation randomised randomised controlled trial RCT readmission recruit recruited recruitment reduced reducing Registered Registration registry required resource rising robust Safe secondary severity small sample size social work Study protocol suggested Treatment Trial well WHO [DOI] 10.1186/s13063-022-06679-x PMC 바로가기 [Article Type] Article
A non-invasive ultrasensitive diagnostic approach for COVID-19 infection using salivary label-free SERS fingerprinting and artificial intelligenceResearch article Published on 2022-09-012022-10-05 Journal: Journal of photochemistry and photobiology. B, Bio [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Accuracy approach artificial intelligence biochemical change Classifier clinical COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 outbreak demonstrated Diagnosis diagnostic diagnostics Efficiency false-negative genetic diversity global healthcare gold standard healthy healthy control high accuracy invasive Label-free limit Machine learning algorithms management MERS-CoV Mutation Nasopharyngeal swab Non-invasive Patient Population screening positive predicted reagents risk Saliva salivary SARS-CoV SARS-CoV-2 SARS-COV-2 infection scattering sensitivity specificity Stage subjects Support surface enhanced Raman spectroscopy SVM the patient virus virus spike protein [DOI] 10.1016/j.jphotobiol.2022.112545 [Article Type] Research article
Can machines learn the mutation signatures of SARS-CoV-2 and enable viral-genotype guided predictive prognosis?기계가 SARS-CoV-2의 돌연변이 신호를 학습하고 바이러스 유전자형 유도 예측 예후를 가능하게 할 수 있습니까?Article Published on 2022-08-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulation added Additive age approach Can caution changes in clade cleaning Continuous driving epitope Epitopes Factor Features Genome genomes genomic data Genotype genotypic global healthcare hallmark HLA Implications Infection information Interaction life threatening machine machine learning machine-learning mutated Mutation Mutation identification mutations nucleotide Pathogens performed Predictive Predictive prognosis Prognosis representing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity Temporal Temporal benchmarking. Total variant variants Viral diseases virus [DOI] 10.1016/j.jmb.2022.167684 PMC 바로가기 [Article Type] Article
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article