Clinical Trial Protocol for ROSELLA: a phase 3 study of relacorilant in combination with nab-paclitaxel versus nab-paclitaxel monotherapy in advanced platinum-resistant ovarian cancerClinical Trial Protocol Published on 2024-07-262024-09-05 Journal: Journal of gynecologic oncology [Category] update2024, [키워드] Glucocorticoid receptor Nab-paclitaxel Neoplasm Drug Resistance Ovarian neoplasms Relacorilant [DOI] 10.3802/jgo.2024.35.e111 PMC 바로가기 [Article Type] Clinical Trial Protocol
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomicsArticle Published on 2024-07-092024-09-05 Journal: Cell Reports Methods [Category] update2024, [키워드] Glucocorticoid receptor Golden Gate assembly interactomics non-structural protein 7 nucleocapsid protein proteomics proximity labeling T2A peptide T2A split/link TurboID [DOI] 10.1016/j.crmeth.2024.100818 PMC 바로가기 [Article Type] Article
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected [DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology
Identification of potentially anti-COVID-19 active drugs using the connectivity MAP연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인Research Article Published on 2022-01-272022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus [DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article
Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era글루코코르티코이드 수용체에 의한 전사 억제: 유전체학 시대를 위한 간결한 모델Review Published on 2021-04-212022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] anti-inflammatory drug clinical effectiveness coordination COVID-19 Effect enhancer enhancers Factor Factors Gene Expression Genes glucocorticoid Glucocorticoid receptor glucocorticoid receptor (GR Glucocorticoids GR, Glucocorticoid receptor GRE, glucocorticoid response element human disease Inflammation Inflammatory inflammatory transcription mechanisms molecular mechanisms monomer negative feedback NF-κB NF-κB signaling nGRE, negative glucocorticoid response element receptor regulated repression second Signaling subset target targets tissue repair Transcription transcription factors transcriptional transcriptional enhancer treat TSS, transcriptional start site widespread [DOI] 10.1016/j.jbc.2021.100687 PMC 바로가기 [Article Type] Review
Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 PathologiesCOVID-19 병리의 알코올 증강의 기본 메커니즘에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-04-012022-08-31 Journal: Alcoholism, clinical and experimental research [Category] MERS, meta-analysis, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alcohol alcohol consumption Analysis anti-inflammatory mediator anti-inflammatory mediators augmentation base bioRxiv caused cellular metabolism changes in clinician conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokines dataset early phase Effect ENhance Ethanol EtOH Fever fibrosis Gene Expression gene expression profile GEO GEO database glucocorticoid Glucocorticoid receptor hepatic fibrosis HMGB1 homeostasis hyperinflammatory phase IL-1 IL-1β IL-6 IL-6 signaling pathways Inflammation Inflammatory mediators Ingenuity Pathway Analysis Ingenuity Pathway Analysis. inhibiting IPA JUN knowledge base lung mapped mediators Meta-analysis metabolism molecule molecules network Network meta-analysis Neuroinflammation pandemic Pathologies pathway Pathways Patient predicted receptor respiratory retrieved risk RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins sequencing data severe acute respiratory syndrome Coronavirus signaling pathway STAT systemic inflammation TNF transcription factors Viral viral infections worldwide crisis [DOI] 10.1111/acer.14573 PMC 바로가기 [Article Type] Meta-Analysis
Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2임상 단계 분자 PT150은 SARS-CoV-2에 대한 항바이러스 활성이 있는 글루코코르티코이드 및 안드로겐 수용체의 조절제입니다.Article Published on 2020-12-012022-09-11 Journal: Cell cycle (Georgetown, Tex.) [Category] SARS, 치료제, [키워드] ACE2 activity androgen Androgen receptor Anti-SARS-CoV-2 Activity antidepressant Antiviral antiviral activities antiviral activity Cell cellular clinical clinical trial Concentration cortisol COVID-19 COVID-19 progression downregulation effective epithelial lining glucocorticoid Glucocorticoid antagonist Glucocorticoid receptor glucocorticoid receptor (GR immunomodulatory effect IND inhibitory member modulating modulation molecules Phase 1 Phase 2 phase 2 clinical trials platform predominant PT150 receptor safety profile SARS-CoV-2 suggested tested therapeutic TMPRSS2 TMPRSS2 expression variety virus [DOI] 10.1080/15384101.2020.1859752 PMC 바로가기 [Article Type] Article
Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2Review Published on 2020-11-012023-07-12 Journal: The Journal of endocrinology [Category] SARS, [키워드] ACE2 angiotensin Corticosteroid COVID-19 Dexamethasone Glucocorticoid receptor nuclear receptor SARS-CoV-2 [DOI] 10.1530/JOE-20-0260 [Article Type] Review
Glucocorticoid‐mediated modulation of morphological changes associated with aging in microgliaArticle Published on 2018-06-072023-08-29 Journal: Aging Cell [Category] E형 간염, [키워드] Glucocorticoid receptor Glucocorticoids hippocampus inflammaging microglia Neuroimmunology Neuroinflammation [DOI] 10.1111/acel.12790 PMC 바로가기
The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cellsT 세포 발달에서 Bcl-2 계열 단백질과 협력하여 글루코코르티코이드 수용체에 의한 미토콘드리아 세포 사멸 경로의 조절The Many Ways of Apoptotic Cell Death Published on 2016-11-262022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] accumulated activated Activation active caspase-3 alternative Apoptosis apoptotic pathway apoptotic pathways apoptotic signaling association Bax BCL-2 Bcl-2 family Bcl-2 family protein Bcl-2 proteins Bcl-x Bim caspase-3 caspase-8 caspase-9 CD4 CD8 classical Combination cross-talk Cytochrome C demonstrated Dexamethasone early phase event genomic glucocorticoid Glucocorticoid hormone Glucocorticoid receptor glucocorticoid receptor (GR Glucocorticoids Hypothesis in vitro Interaction investigated involved mice Mitochondria mitochondrial mitochondrial accumulation mitochondrial apoptotic pathway mitochondrial translocation molecular non-genomic Non-genomic pathway offered pathway Pathways receptor regulate Regulation remained sensitivity Signaling Support T cell thymocyte Thymocyte apoptosis thymocytes treated Treatment [DOI] 10.1007/s10495-016-1320-8 PMC 바로가기 [Article Type] The Many Ways of Apoptotic Cell Death