The role of the glucocorticoid receptor and its impact on steroid response in moderate-severe COVID-19 patientsArticle Published on 2023-01-302024-09-05 Journal: European journal of pharmacology [Category] update2024, [키워드] Corticosteroids COVID-19 GILZ Glucocorticoid receptors isoform IκBα Mutation NR3C1 gene [DOI] 10.1016/j.ejphar.2023.175555 PMC 바로가기 [Article Type] Article
Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infectionSARS-COV-2 감염에 대한 잠재적 약물로서 덱사메타손의 용도를 다른 용도를위한 약물 유전전증 고려 사항Review Published on 2021-06-042022-08-31 Journal: Personalized Medicine [Category] MERS, SARS, 신약개발, 유전자 메커니즘, [키워드] Abstract agonist analgesic effect analgesic effects anti-inflammatory drug benefit changes in chronic patients clinically Control Corticosteroid COVID-19 COVID-19 case Critical cure CYP3A5 Dexamethasone drug drug response Effect effort evaluate Factor Genetic genetic factors Genetic variation glucocorticoid Glucocorticoid receptors Health Organization immunomodulatory drugs individual individuals inherent involved metabolism metabolome NR3C1 NR3C2 outcome pathway Patient patients pharmacogenetics pharmacokinetic pharmacokinetics Potential treatment Randomized controlled trials receptors recovery RECOVERY trial reduce mortality Regulatory reported SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient severe COVID-19 patients therapy Transcriptome United Kingdom Usage World Health Organization [DOI] 10.2217/pme-2020-0183 PMC 바로가기 [Article Type] Review
Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes: An in silico perspectiveArticle Published on 2021-04-182023-06-16 Journal: Computers in biology and medicine [Category] MERS, SARS, [키워드] anti-inflammatory activity antiviral activity COVID-19 Cytokine storm Glucocorticoid receptors Pregnanes [DOI] 10.1016/j.compbiomed.2021.104406 PMC 바로가기 [Article Type] Article