Metabolism and Nutrition of L-Glutamate and L-Glutamine in RuminantsReview Published on 2024-06-142024-09-05 Journal: Animals : an Open Access Journal from MDPI [Category] update2024, [키워드] amino acids Glutamate Glutamine Health metabolism nutrition ruminants [DOI] 10.3390/ani14121788 PMC 바로가기 [Article Type] Review
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Electrostatic Map of the SARS-CoV-2 Virion Specifies Binding Sites of the Antiviral Cationic PhotosensitizerSARS-CoV-2 Virion의 정전기 지도는 항바이러스 양이온 광감작제의 결합 부위를 지정합니다Article Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] antibodies Antiviral Brownian dynamics coarse-grain model component computational method different materials distribution domain drugs E protein electrostatic electrostatic interactions Electrostatics Glutamate glutamate residue groups heterogeneous host cells Interaction Lipid lipids Map Numerous oxygen photosensitizer phthalocyanine positive Positive Charge predict Protein Proteins Reactions reactive oxygen SARS-CoV-2 Site Structure target the SARS-CoV-2 understanding viral envelope viral membrane virion virus Zinc [DOI] 10.3390/ijms23137304 PMC 바로가기 [Article Type] Article
Cryo-EM structures of human bradykinin receptor-G q proteins complexesArticle Published on 2022-02-072022-10-04 Journal: Nature Communications [Category] 변종, [키워드] acting Activation agonist binding cardiovascular system complex complexes conformational change conserved Cryo-electron microscopy cryo-EM cryo-EM structure Cryoelectron microscopy determine dysfunction G protein-coupled receptor G protein-coupled receptors Glutamate induce Inflammation Interaction Ligand mechanism molecular mechanism motifs Pain peptide peptides PROTECT Protein Proteins receptor Receptor pharmacology Structure Type [DOI] 10.1038/s41467-022-28399-1 PMC 바로가기 [Article Type] Article
Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)SARS-CoV-2의 세포 친화성, COVID-19의 병태생리학 및 이러한 매개체의 발현을 조절할 수 있는 microRNA의 식별에 연루된 숙주 세포 진입 매개체(검토)Review Published on 2022-02-012022-09-11 Journal: International journal of molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAM17 Affect angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association Basigin binding Biomarker Candidates canonical cell entry cellular tropism changes in Clinical outcome clinical utility complexity coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 dependent on domain enzyme expression expression level Future Genes Glucose Glutamate GRP78 host cell host cells implicated in silico analysis indicated Kidney injury mechanism microRNA miRNA miRNAs modulate Necrosis NPR1 pathophysiology Patient protease Protein provide recent receptor Regulation review SARS‑CoV2 Serine serine 2 severe acute respiratory syndrome Coronavirus therapeutic target TLR4 TMPRSS2 TMPRSS4 transmembrane [DOI] 10.3892/ijmm.2021.5075 PMC 바로가기 [Article Type] Review
Analysis of Clinical Parameters, Drug Consumption and Use of Health Resources in a Southern European Population with Alcohol Abuse Disorder during COVID-19 PandemicCOVID-19 Pandemic 동안 알코올 남용 장애가있는 남유럽 인구에서 임상 파라미터, 약물 소비 및 건강 자원 사용 분석Observational Study Published on 2022-01-262022-08-31 Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료제, [키워드] Abuse alarm alcohol Alcohol Abuse alcohol dependence alcohol use disorder antidepressants benzodiazepines body mass body mass index Care changes in cholesterol clinical clinical variable clinical variables clinically Consumption country COVID-19 COVID-19 pandemic creatinine decompensation Diagnosis Diastolic blood pressure disorder disorders Disruption dose drug electronic medical record electronic medical records EMR glomerular filtration Glutamate HDL Health health resource health resources Health Service Health services healthcare LDL lifestyle lockdown maintenance men moderate Oxaloacetate Patient per day pharmacological Population primary care Psychological pyruvate Regional Registered reorganization resource service Social service social services Southern European Spain Student’s t -test Systolic blood pressure Total cholesterol triglycerides variable vulnerable population was performed [DOI] 10.3390/ijerph19031358 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cellsArticle Published on 2021-12-142022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral binding Cell Clathrin-mediated endocytosis coronavirus Coronavirus infection decrease facilitate Glutamate identify infect cell interact involved knockdown Lungs Mechanisms of disease mice Middle East Molecular biology nasal turbinate receptor reduced respiratory syndrome coronavirus SARS-CoV spike protein SARS-CoV-2 SARS-COV-2 infection significantly Spike protein the SARS-CoV-2 viral infection [DOI] 10.1038/s41421-021-00357-z PMC 바로가기 [Article Type] Article
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infectionCOVID-19의 위험 계층화 및 질병 중증도 및 사망률 예측: COVID-19 감염에 대한 숙주 반응 측정을 위한 차세대 대사체학Research Article Published on 2021-12-012022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] abnormality Admission alteration association AUC biochemical Carnitine change changes in Characteristics characterized citrulline clinical evaluation Clinical management clinical severity score collected Comorbidities Comorbidity Concentration Confirmed COVID-19 infection COVID-19 COVID-19 infection COVID-19 severity Curve demographics determinant develop disease disease severity enrolled Glutamate healthy volunteers highest Host host response identify immune signature implication individual investigated Kynurenine mass spectrometry measure medical records metabolic factors metabolism metabolite metabolites metabolomics Mild moderate morbidity morbidity and mortality Mortality organic acid ornithine Patient Peripheral blood Peripheral blood sample peripheral blood samples plasma predictor profile Prognosis Prognostic marker Prognostic markers Quantitative receiver risk risk stratification ROC RT-PCR selected severe complication severe complications severity tested Tryptophan urea urea cycle WHO [DOI] 10.1371/journal.pone.0259909 PMC 바로가기 [Article Type] Research Article
Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?Review Published on 2021-10-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] affecting Cell cell death component contributing to COVID-19 cytoplasm damage erastin Fatty acid Ferroptosis Glutamate GPX4 GSH GSH-GPX4 axis inactivation inducer inhibit Intervention iron kidney leading lipid peroxides Manifestations metabolism molecular mechanism Multiorgan Multiorgan damage multiple organs Myocardial myocarditis oxidative stress pathology Polyunsaturated precursor Process programmed cell death promoted reactive oxygen specy reduce reported SARS-CoV-2 SARS-COV-2 infection Shock upregulation [DOI] 10.3390/antiox10111677 PMC 바로가기 [Article Type] Review
SARS-CoV-2, Trait Anxiety, and the MicrobiomePsychiatry Published on 2021-09-082022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Accuracy Activation Affect antibody Anxiety anxiety disorders Brain cause caused Central nervous system CNS Cognition cognitive COVID-19 COVID-19 pandemic Critical default mode network disease Effect effective Effects Efficiency elevated example Glutamate glutamic acid high-density homeostatic Host human host Immunity Immunological response immunological responses Infection information mechanism microbial Microbiome microbiota microglial modulating modulation neuronal pathology priming Research SARS-CoV-2 structures subsequent susceptibility Symptom toll-like receptor signaling Treatment turn viral infection virus [DOI] 10.3389/fpsyt.2021.720082 PMC 바로가기 [Article Type] Psychiatry