Metabolism and Nutrition of L-Glutamate and L-Glutamine in RuminantsReview Published on 2024-06-142024-09-05 Journal: Animals : an Open Access Journal from MDPI [Category] update2024, [키워드] amino acids Glutamate Glutamine Health metabolism nutrition ruminants [DOI] 10.3390/ani14121788 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificitySARS-CoV-2 주요 프로테아제 기질 펩타이드 특이성 분석을 위한 proteomics-MM/PBSA 이중 접근법Article Published on 2022-08-012022-09-11 Journal: Peptides [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] Amine amino acids Analysis approach Area binding energy carried cleavage site Combination COVID-19 determine diagnostic drug drug target Effects enzyme expected free energy Free energy calculations Glutamine identify indicated introduced lung M pro main protease Mechanics MM/PBSA Molecular mechanics pathogenicity peptide Perspective protease proteome proteomics SARS-CoV-2 SARS-CoV-2 main protease specificity structural homology substrate substrates surface surface area TAILS. terminal unique variant virus [DOI] 10.1016/j.peptides.2022.170814 PMC 바로가기 [Article Type] Article
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies이종 saRNA 프라임, DNA 이중 항원 부스트 SARS-CoV-2 백신 접종으로 강력한 세포 면역원성과 교차 변형 중화 항체 유도Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Adenovirus animal model animal models B.1.617.2 Beta boost CD4+ CD8+ T-cell combinations COVID-19 D614G mutation Delta distribution DNA dual dual antigen ENCODE enhanced expression followed by furin furin cleavage region Glutamine Heterologous highest homologous homologous or heterologous Humoral response humoral responses IgG immune response immune responses immunogenicity lipid carrier MHC class I MHC class I and II mice motif N antigen Neutralizing nucleic acid nucleocapsid omicron peptide peptides prefusion conformation prime proline prolines protease pseudovirus receiving regimen regimens Region response RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant self-amplifying RNA sequence sera serotype spike Stimulation strain Strains Support T-cell T-cell responses vaccination Vaccine Vaccines variant wild type Wuhan [DOI] 10.3389/fimmu.2022.910136 PMC 바로가기 [Article Type] Article
Paxlovid: Mechanism of Action, Synthesis, and In Silico StudyPaxlovid: 작용 메커니즘, 종합 및 인 실리코 연구Review Published on 2022-07-072022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 치료제, [키워드] Action antiviral activity antiviral drug antiviral efficacy antivirus antiviruses Biochemistry candidate cleave clinical trial Combination coronavirus COVID COVID-19 COVID-19 pandemic described description drug flexible Glutamine human coronavirus Immune profile in vitro in vivo inhibiting inhibitor mechanism mechanism of action molnupiravir Nirmatrelvir Organic chemistry pandemic Paxlovid PF-07321332 Pfizer Pharmacology polyprotein protease Protease inhibitor Proteases replaced REPLACED BY reported Ritonavir SARS-CoV-2 protease synthesis Treatment treatment of COVID-19 Vaccine viral replication [DOI] 10.1155/2022/7341493 PMC 바로가기 [Article Type] Review
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography [DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article
The Catalytic Mechanism of Pdx2 Glutaminase Driven by a Cys-His-Glu Triad: A Computational StudyArticle Published on 2022-05-042024-08-28 Journal: ChemBioChem [Category] 말라리아, [키워드] catalytic mechanisms glutaminase Glutamine pyridoxal 5’-phosphate synthase. QM/MM
Identification of a novel SARS-CoV-2 variant with a truncated protein in ORF8 gene by next generation sequencing차세대 시퀀싱에 의한 ORF8 유전자의 절단된 단백질을 갖는 신규 SARS-CoV-2 변이체 식별Article Published on 2022-03-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptive addition America Amino acid Canada changed Complete D614G mutation database distribution Evolution Genome Germany GISAID GISAID database Glutamine Greece growth advantage identification India indicate Japan Latvia Lineage Mutation NCBI nucleotide nucleotides ORF8 gene ORF8 protein Point mutation Protein ranged resulting Russia SAR-CoV-2 SARS-CoV-2 variant Sequencing sequencing technology STOP stop codon the Spike the United State United States variant viral genome virus wild type [DOI] 10.1038/s41598-022-08780-2 PMC 바로가기 [Article Type] Article
Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its AnalogsArticle Published on 2022-02-132022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] activity addition Amphibian AMPs analyzed antimicrobial antimicrobial peptide antimicrobial peptides Antiviral antiviral activity antiviral agent Antiviral effect antiviral therapy Compound Coronaviruses COVID-19 pandemic cytotoxicity demonstrated DNA and RNA drug drug resistance evaluated evidenced frog peptides Glutamine Gram-negative bacteria help herpesviruses HSV-1 Influenza virus inhibit inhibition activity MOST overcome peptide peptides previous study Pro proline reduced replaced Replication rising SARS-CoV-2 selective Temporin temporins Therapeutic molecule therapeutic option Threats viral family virus Virus-host interaction viruses widespread [DOI] 10.3390/ijms23042060 PMC 바로가기 [Article Type] Article
Disturbed lipid and amino acid metabolisms in COVID-19 patientsCOVID-19 환자의 지질 및 아미노산 대사 장애Original Article Published on 2022-01-222022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] 바이오마커, [키워드] alteration Amino acid amino acid metabolism Analysis arachidonic acid arginine Biomarker control patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Disturbed GABA gamma-aminobutyric acid Glutamine Healthcare systems hospitalized COVID-19 patient identification impacted indicated Infection information Intervention lead matched controls metabolic disturbance metabolic disturbances metabolic pathway metabolic pathways metabolism metabolisms metabolite metabolomics pandemic pathway Pathways Patient performed plasma plasma sample plasma samples reduced sensitivity severe COVID-19 significantly sphingolipid Stratification supplementary material System systemic reaction systemic reactions therapeutic target therapeutic targets Tryptophan tyrosine Viral viral infection [DOI] 10.1007/s00109-022-02177-4 PMC 바로가기 [Article Type] Original Article