The glycobiology of plasmodium falciparum: New approaches and recent advancesArticle Published on 2023-09-302024-09-10 Journal: Biotechnol Adv [Category] 말라리아, [키워드] glycans glycobiology Glycoconjugates glycoproteomics lectins malaria Plasmodium falciparum PMC 바로가기
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infectionarticle Published on 2023-08-152024-09-05 Journal: Cellular & molecular immunology [Category] update2024, [키워드] Glycan-binding proteins glycans glycosylation immune response Infection Inflammation Mechanisms of disease Translational immunology [DOI] 10.1038/s41423-023-01074-1 PMC 바로가기 [Article Type] article
Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2Article Published on 2022-12-012022-11-16 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor Affect angiotensin-converting enzyme 2 Area B.1.1.529 binding binding efficiency binding free energy conformation domain dominant explicit full-length glycans glycoprotein host cells hydrophobic interaction infect Infection initiated Interaction interactions ions Mechanics MMPBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated Mutation omicron Omicron variant performed RBD RBD-ACE2 receptor residue Salt Bridge SARS-CoV-2 SARS-CoV-2 spike glycoprotein Simulation spike spike glycoprotein strain surface the receptor-binding domain trajectory variant variant of SARS-CoV-2 variants wild-type [DOI] 10.1016/j.jmgm.2022.108286 PMC 바로가기
Molecular dynamics studies reveal structural and functional features of the SARS-CoV-2 spike protein분자 역학 연구는 SARS-CoV-2 스파이크 단백질의 구조적 및 기능적 특징을 보여줍니다Review Published on 2022-09-012022-09-11 Journal: Bioessays [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] approach atomic level Cell Computational approaches conformational changes COVID-19 pandemic Drug repurposing effort epitope Epitopes feature functional glycans Infection Invasion molecular molecular dynamics Perspective Protein responsible S protein SARS-CoV-2 SARS-CoV-2 virus Scientific community Spike protein the SARS-CoV-2 the spike protein variant variants [DOI] 10.1002/bies.202200060 PMC 바로가기 [Article Type] Review
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoproteinArticle Published on 2022-08-042023-07-09 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), [키워드] benzene mapping coronavirus COVID-19 cryptic pockets glycans hydrogen-deuterium exchange mass spectrometry Molecular dynamics simulation omicron Spike protein [DOI] 10.1016/j.str.2022.05.006 PMC 바로가기
Structural Evolution of Delta (B.1.617.2) and Omicron (BA.1) Spike Glycoproteins델타(B.1.617.2) 및 오미크론(BA.1) 스파이크 당단백질의 구조적 진화Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] accumulated alteration B.1.617.2 binding caused conservation coronavirus COVID-19 COVID-19 pandemic Delta elements Evolution fusion genomic data glycan glycans glycoprotein host cell human ACE2 receptor involved membrane fusion molecular molecular dynamics monomer mutants Mutation offer omicron proximal RBD receptor ACE2 Receptor binding domain receptor binding motif Region S glycoprotein SARS-CoV-2 spike structural evidence Transmissibility unique variants virus entry [DOI] 10.3390/ijms23158680 PMC 바로가기 [Article Type] Article
Structural and Dynamic Insights into SARS-CoV-2 Spike-Protein-Montmorillonite InteractionsSARS-CoV-2 스파이크-단백질-몬모릴로나이트 상호작용에 대한 구조적 및 동적 통찰력Article Published on 2022-08-022022-09-11 Journal: Langmuir : the ACS journal of surfaces and colloid [Category] COVID19(2023년), SARS, 변종, [키워드] Cell cell entry Critical develop drug drug therapy dynamic effective electrostatic explicit glycan glycans help hydrophobic hydrophobic interaction hydrophobic interactions immune response insight Interaction interactions Ion mechanism Modification molecular dynamics Molecular dynamics simulation Montmorillonite nanoparticle pandemic performed probe Protein provide residue residues S protein SARS-CoV-2 therapeutic therapy Vaccine Vaccine development Vaccines variant virus world population [DOI] 10.1021/acs.langmuir.2c00837 PMC 바로가기 [Article Type] Article
Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variantSARS-CoV-2 Omicron 변이체의 스파이크 단백질 N-말단 및 수용체 결합 도메인의 구조적 특성에 대한 통찰력Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility ACE2 addition Analysis antibody B.1.1.529 BA.1) binding binding domain binding efficiency changes in computational analysis COVID-19 COVID-19 vaccines Effect Epitopes evaluated free energy glycan glycans higher infectivity insight Interaction mAb molecular dynamics molecular dynamics simulations Mutation N-terminal N-terminal domain N-terminal domain (NTD) Neutralizing NTD NTDs omicron Omicron (B.1.1.529 Omicron variant performed Protein provide raised RBD RBD domain RBDs Receptor binding domain receptor binding domain (RBD) reduce reducing residue SARS-CoV-2 specific antibodies Spike protein stability the RBD the SARS-CoV-2 the spike protein variant variant of SARS-CoV-2 Wuhan [DOI] 10.1016/j.compbiomed.2022.105735 PMC 바로가기 [Article Type] Article
Binding of synthetic carbohydrate receptors to enveloped virus glycans: Insights from molecular dynamics simulationsArticle Published on 2022-08-012023-07-09 Journal: Carbohydrate Research [Category] COVID19(2023년), [키워드] Antiviral agents glycans molecular dynamics simulations Supramolecular chemistry viruses [DOI] 10.1016/j.carres.2022.108574 PMC 바로가기
The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor녹차 카테킨 EGCG는 범 코로나바이러스 부착 억제제에 대한 개념 증명을 제공합니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity attachment block catechin caused Cell conserved coronavirus Coronavirus-2 Coronaviruses CoV CoV infection COVID-19 pandemic CoVs EGCG Endemic epigallocatechin epigallocatechin gallate epithelial cells gallate glycans green tea HCoV-OC43 Health heparan sulfate heparin highlight highly pathogenic CoVs Infection inhibitor inhibitors Lentiviral particle lentiviral particles Lung epithelial cells mechanism murine Prevent PROTECT Proteoglycan provide pseudotyped rapid response reduce remained required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spike protein Spike proteins sulfate target cell Treatment Vaccine development virion binding virus [DOI] 10.1038/s41598-022-17088-0 PMC 바로가기 [Article Type] Article