Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics proteomics. pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic VirusesArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Activation Antiviral agents antiviral drug cause Cell change changes changes in coronavirus D-Mannose Effect Glucose Glycolysis glycosylation host cell infected cell Infection Influenza virus inhibitors limit mechanism metabolic shift Mimetic noroviruses novel analogs Other pathway pharmacokinetic reduce respond rhinoviruses SARS-CoV-2 target therapeutic approach upregulated viral infections Viral infections. Zika virus [DOI] 10.3390/molecules27185928 PMC 바로가기
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research
Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases면역 요법 및 인간 질병에서 사이토카인 방출에 기여하는 게놈 결정인자의 식별Article Published on 2022-07-282022-09-11 Journal: Journal of Translational Medicine [Category] Coronavirus, 유전자 메커니즘, [키워드] abrogate Analysis Autoimmune diseases CAR CAR T-cell therapy CD22 cells cellular Cohort cohorts collected contribute contributing to CRS cytokine release Cytokine release syndrome dataset determinant develop driving drugs targeting expression Frequency genomic Glycolysis human disease identification immune system Immunotherapy IMPROVE in vivo Infection Influenza influenza infection influenza infections lupus erythematosus management mRNA not increased occur outcomes pathway Patient patients with influenza PFKFB4 PFKFB4. platform Prevent reaction reduce RNA extraction severity SLE syndrome systemic lupus erythematosus T-cell T-cells targeted therapy therapy tissues Treatment Tumor upregulated was used were used while with COVID-19 [DOI] 10.1186/s12967-022-03531-3 PMC 바로가기 [Article Type] Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절Review Published on 2022-07-232022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법, [키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule. stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus [DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics Reviews Published on 2022-07-072022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 신약개발, [키워드] Activation addition biological processes Cancer Cell cell metabolism cell proliferation cellular pathways change Chronic diseases disease Diseases downstream gene drugs Endoplasmic reticulum ERK expression Extracellular Factor Glycolysis Health hypoxia immune response implication Infection interact involved kinase mammalian cells mechanism Metastasis microbe Molecular oxygen NF-κB nuclear oxygen pathogenic pathway question Rapamycin reaction regulate respond responses Signaling Stress subsequent therapeutic therapeutic target tumorigenesis [DOI] 10.1038/s41392-022-01080-1 [Article Type] Reviews
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesisSARS-CoV-2는 활성화된 뉴클레오티드 합성에 대한 염증 반응의 회피를 결합합니다Article Published on 2022-06-282022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus aerobic aerobic glycolysis Antiviral antivirals aspartate CAD cellular coronavirus de novo deamidation deplete dihydroorotase effective enzyme evidenced Genetic changes Glycolysis highlighting host immunity Inflammatory Inflammatory response inhibitor metabolism metabolism. metabolite metabolites NF-κB NF-κB activation Nsp9 nucleotide offer pressure promote provide pyrimidine RELA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent targeting up-regulate Vaccinations variant Waves while [DOI] 10.1073/pnas.2122897119 PMC 바로가기 [Article Type] Article
Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients입원 시 해당과정 부산물인 메틸글리옥살의 혈장 수준 상승은 ICU COVID-19 환자의 사망률에 대한 독립적인 바이오마커입니다Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] MERS, 바이오마커, 치료기술, 치료법, [키워드] Admission Biomarker Biomarkers byproduct Care correlated COVID-19 patient COVID-19 patients CRP death died elevated enzyme Evidence evidence of explained glutathione Glycolysis high risk ICU ICU patient ICU Patients identify IL-1β independent inflammation markers Logistic regression analysis management methylglyoxal monocyte Monocytes Mortality on admission Patient plasma Plasma levels predict provide regression analysis survived therapeutic These data TNF-α uninfected control Variability [DOI] 10.1038/s41598-022-12751-y PMC 바로가기 [Article Type] Article