goblet cells – Communicable Diseases Research

Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease

Article

Published on 2022-08-312023-07-10
Journal: Microbiology Spectrum [Category] COVID19(2023년),

Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice

FVB 배경 마우스에서 SARS-CoV-2 감염에 민감하고 내성이 있는 형질전환 모델 개발

Article

Published on 2022-07-262022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome coronavirus atrophy caused Cerebellum cerebrum coronavirus 2 coronavirus disease COVID-19 COVID-19 pandemic development disease exhibited Goblet cell goblet cells hACE2 histopathological finding histopathological findings hyperplasia K18-hACE2 K18-hACE2 mice lung Lungs mice Mild mild pneumonia overcome Pneumonia reduction respiratory SARS-CoV-2 SARS-COV-2 infection sensitivities Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia small intestine spleen strain susceptibility susceptible Therapeutics transgenic mice transgenic model Vaccine viral titer weight loss White pulp
[DOI] 10.1371/journal.pone.0272019 PMC 바로가기 [Article Type] Article

Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections

세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다

Article

Published on 2022-06-282022-09-11
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein
[DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article

The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ

Research Article

Published on 2021-12-222022-10-30
Journal: mSphere [Category] Coronavirus,

[키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting
[DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Cellular and Infection Microbiology

Published on 2021-11-012022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19,

High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells

인간 결막 잔 세포에서 SARS-CoV-2 진입 인자의 높은 발현

Review

Published on 2021-04-012022-09-11
Journal: Experimental eye research [Category] MERS, SARS, 유전자 메커니즘, 진단,

The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model

위장관은 비인간 영장류 모델에서 SARS-CoV-2 감염에 대한 대체 경로입니다

Article

Published on 2021-04-012022-09-11
Journal: Gastroenterology [Category] MERS, SARS, 바이오마커, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caspase 3 caused CD68 Chain Reaction change cleaved Clinical sign Clinical signs connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines digestive dysfunction evaluated fecal Fecal-Oral Route Gastrointestinal GI Tract goblet cells Histopathology host responses Hypothesis immunohistochemistry increased expression increasingly Infection Inflammation Inflammatory cytokines inoculation intranasal investigated involved Ki67 lung macrophages manifestation Model mucin NHP Pathogenesis pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathologic Patient periodic acid Pneumonia polymerase chain polymerase chain reaction primate quantified Quantitative reported respiratory respiratory tissue respiratory tissues response reverse transcription rhesus Rhesus monkeys route SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe infections staining tissue tissues tract Viral viral genomic RNA viral infection were infected were recorded
[DOI] 10.1053/j.gastro.2020.12.001 PMC 바로가기 [Article Type] Article

Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections

Review

Published on 2021-01-292022-10-28
Journal: Biology [Category] COVID-19,

[키워드] acute respiratory disease acute respiratory syndrome airways arising Bearing Cell cellular and molecular changes in chronic respiratory disease ciliary ciliated ciliated cells clearance coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 Defense develop directional disrupt driven by dysfunction elicit epithelial epithelium Genetic goblet cells Health healthy help host infection Human implication include individual Infection integrity Interaction involved lethal infection lung lung cilia maintain management MCC mechanism microbial infection microbial infections molecular molecular component Mucociliary clearance Mucus nasopharynx novel virus pandemic pathogen pathophysiology Patient predicted Protein pulmonary Pulmonary function regulate respiratory Respiratory disease respiratory diseases respiratory epithelium Respiratory system respiratory tract SARS-CoV-2 viral simple Surveillance susceptible transcriptional
[DOI] 10.3390/biology10020095 PMC 바로가기 [Article Type] Review

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

SARS-CoV-2와 관련된 인간 폐의 노화 전사체 및 세포 경관

Article

Published on 2021-01-042022-09-10
Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단,

[키워드] age airway smooth muscle alveolar Analysis basal cells Cell cells cellular change characterized contribute coronavirus coronavirus disease COVID-19 Data integration deconvolution analysis decrease dendritic cell dendritic cells dysregulated Endothelial cell endothelial cells Factor feature fibroblasts goblet cells human lung identify IGSF21 Immunogenetics in vitro lung Mitochondria Older Patient pericytes populations proportion proportions proteome reduced Replication responses reveal risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 proteome severe coronavirus disease severe COVID-19 severity of COVID-19 smooth muscle Stress stress responses the SARS-CoV-2 the strongest transcriptional transcriptionally Transcriptome transcriptomes viral infection
[DOI] 10.1038/s41467-020-20323-9 PMC 바로가기 [Article Type] Article

Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium

Research Article

Published on 2020-11-062022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome airway airway epithelia airway epithelial damage airway epithelium Basal cell basolateral side cause caused characterized ciliated ciliated cell club cell Club cells confirmed case contribute coronavirus coronavirus disease COVID-19 COVID-19 patients Culture damaged demonstrated dominant donors epithelial epithelial cell epithelial damage epithelium exhibit expression fatality Goblet cell goblet cells HAE highlight Human human airway epithelia Human airway epithelium human airways in vitro in vitro model in vivo independent infect Infection infections initiate long-lasting long-term infection lung maintain mimicking modeling pandemic progeny proliferation recurrent infection replicate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication Support tested the SARS-CoV-2 tight junction Viral load virion virus virus infection virus replication ZO-1
[DOI] 10.1128/mBio.02852-20 PMC 바로가기 [Article Type] Research Article