Nutrient Limitation Mimics Artemisinin Tolerance in Malaria영양소 제한이 말라리아에서 아르테미시닌 내성을 모방한다.Article Published on 2023-04-252024-08-01 Journal: mBio [Category] 말라리아, [키워드] Artemisinin drug resistance evolution GSEA nutrient starvation Parasitology physiological media RNA-Seq stress response Tolerance [DOI] 10.1128/mbio.00705-23 PMC 바로가기
HPAI-resistant Ri chickens exhibit elevated antiviral immune-related gene expressionArticle Published on 2023-01-012023-06-22 Journal: Journal of veterinary science [Category] 조류인플루엔자, [키워드] GSEA influenza A virus Ri chicken RNA-Seq signaling pathway [DOI] 10.4142/jvs.22229 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Gene Set Enrichment Analysis Reveals That Fucoidan Induces Type I IFN Pathways in BMDC유전자 세트 농축 분석을 통해 후코이단이 BMDC에서 I형 IFN 경로를 유도한다는 사실이 밝혀졌습니다Article Published on 2022-05-272022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Analysis Antigen presentation Antiviral antiviral activity BMDC CD40 CD80 cytometric DEGs dendritic dendritic cell dendritic cells differentially expressed gene Differentially expressed genes differentially expressed genes (DEGs) driven by enrichment enrichment analysis Flow Flow cytometric analysis fucoidan gene set enrichment analysis gene set enrichment analysis (GSEA) greater GSEA highlighting IFN IFN-stimulated gene immune cells Inflammatory response innate immune Innate immune cells IRF ISG ISGs maturation mechanism MHCII NF-κB NLR nucleic acid pathway Pathways polysaccharide potential mechanism Prevent PRR receptor SARS-CoV-2 Signaling STAT STING sulfated surface marker TLR transcription factors transcriptional change transcriptionally Transcriptome transcriptome change treat Type type I Type I IFN type I interferon upregulated viral infections viruses [DOI] 10.3390/nu14112242 PMC 바로가기 [Article Type] Article
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2–Related Genes in Kidney Renal Clear Cell CarcinomaBioengineering and Biotechnology Published on 2022-01-242022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] ACADM Accuracy Analysis applicability carcinoma caused Cell CENPF cohorts correlation COVID-19 CTLA-4 dataset enrichment analysis exhibit expand expressed gene expression follicular General population Genes global public health GSEA higher risk immune Immune cell indicated investigated kidney renal clear cell carcinoma LAG-3 Macrophage malignancy nomogram novel pathway Patient patients PDCD1 PLOD2 potential therapeutic target prediction Predictive predictor prognostic prognostic signature proportion provided Regulatory T cell renal reported SARS-CoV-2 SARS-COV-2 infection serious complication severe disease signature significantly survival TIGIT tissues Tregs TRMT1 urinary system [DOI] 10.3389/fbioe.2021.744659 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Molecular Mechanisms of Cardiac Injury Associated With Myocardial SARS-CoV-2 InfectionCardiovascular Medicine Published on 2022-01-202022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] activated acute respiratory syndrome Analysis Apoptosis Bioinformatics analysis cardiac cardiac injury caused Cell cellular coronavirus Coronavirus disease 2019 COVID-19 Cytokine activation dataset DEGs differentially expressed gene drug enrichment analysis excessive inflammatory response expression profiling functional Gene Expression Omnibus Genes Genome GEO GSEA hypoxia immune Inflammation inhibited Injury involved KEGG Kyoto myocardial injury Ontology Pathogenesis Pathway analysis patients with COVID-19 PPI Protein–protein interaction reduction response resulting RNA-Seq SARS-CoV-2 SARS-COV-2 infection Spread upregulated gene was obtained [DOI] 10.3389/fcvm.2021.643958 PMC 바로가기 [Article Type] Cardiovascular Medicine
Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltrationResearch Paper Published on 2022-01-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] acute respiratory syndrome Algorithms Analysis cellular CIBERSORT clinicopathological parameter coronavirus correlated COVID-19 Cox regression Decreased DNA methylation drug target examined exhibited expression GEO global pandemic GSEA HPA immune Immune cell infiltration immune infiltration investigated KEGG lung cancer lung cancer patient lung cancer patients metabolic pathway molecular function mRNA mRNA expression outcome pathway Patient performed poor prognosis predict predictive power prognostic prognostic biomarker Prognostic value protease protein expression reduced SARS-CoV-2 SARS-CoV-infected cells serine 2 significantly Spread survival therapeutic target TMPRSS2 TMPRSS2 expression transmembrane was determined [DOI] 10.18632/aging.203823 PMC 바로가기 [Article Type] Research Paper
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severityResearch article Published on 2021-10-012022-10-05 Journal: iScience [Category] 변종, 유전자 메커니즘, [키워드] Analysis association Biological sciences caused Chinese cholesterol clinical assessment comprehensive analysis contribute COVID-19 diagnosis COVID-19 pandemic COVID-19 severity current death disease disease severity explain functional gene gene-based analysis Genetic genetic mechanism genetic study genetics GSEA GWAS Host IFN Infection Innate immunity interferon Laboratory mendelian randomization MHC complex MR study Pathways Patient Receptor binding risk factor SARS Coronavirus traits Treatment type I interferon Virology WBC [DOI] 10.1016/j.isci.2021.103186 [Article Type] Research article