Two new and effective food-extracted immunomodulatory agents exhibit anti-inflammatory response activity in the hACE2 acute lung injury murine model of COVID-19Immunology Original Research Published on 2024-05-142024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] ajoene-enriched garlic extract Anti-inflammatory COVID-19 hACE2 sulforaphane [DOI] 10.3389/fimmu.2024.1374541 PMC 바로가기 [Article Type] Immunology Original Research
Coronavirus Spike-RBD Variants Differentially Bind to the Human ACE2 ReceptorArticle Published on 2024-03-082024-09-05 Journal: bioRxiv [Category] update2024, [키워드] ACE2 downregulation hACE2 NL63 Omicron variant RBD SARS-CoV-2 Spike protein Xbb.1.5 variant [DOI] 10.1101/2024.03.07.583944 PMC 바로가기 [Article Type] Article
Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-Cov-2-Spike-RBD ProteinArticle Published on 2024-03-082024-09-05 Journal: bioRxiv [Category] update2024, [키워드] ACE2 downregulation hACE2 NL63 Omicron variant RBD SARS-CoV-2 Spike protein Xbb.1.5 variant [DOI] 10.1101/2024.03.07.583884 PMC 바로가기 [Article Type] Article
Computational design of medicinal compounds to inhibit RBD-hACE2 interaction in the Omicron variant: unveiling a vulnerable target siteArticle Published on 2023-05-252024-09-05 Journal: Informatics in Medicine Unlocked [Category] update2024, [키워드] BA.2 hACE2 MD simulation RBD SARS-CoV-2 Virtual screening [DOI] 10.1016/j.imu.2023.101281 PMC 바로가기 [Article Type] Article
The influence of SARS‐CoV ‐2 infection on expression of drug‐metabolizing enzymes and transporters in a hACE2 murine modelOriginal Article Published on 2023-05-032024-09-05 Journal: Pharmacology Research & Perspectives [Category] update2024, [키워드] COVID‐19 drug transporters drug‐metabolizing enzymes hACE2 SARS‐CoV‐2 [DOI] 10.1002/prp2.1071 PMC 바로가기 [Article Type] Original Article
Functionalized protein microparticles targeting hACE2 as a novel preventive strategy for SARS-CoV-2 infectionArticle Published on 2023-04-052024-09-05 Journal: International journal of pharmaceutics [Category] update2024, [키워드] hACE2 Preventive strategy Protein microparticles SARS-CoV-2 [DOI] 10.1016/j.ijpharm.2023.122921 PMC 바로가기 [Article Type] Article
Molecular recognition of SARS-CoV-2 spike protein with three essential partners: exploring possible immune escape mechanisms of viral mutantsOriginal Paper Published on 2023-03-242024-09-05 Journal: Journal of molecular modeling [Category] update2024, [키워드] antibody hACE2 Molecular dynamics simulation SARS-CoV-2 TMPRSS2 [DOI] 10.1007/s00894-023-05509-4 PMC 바로가기 [Article Type] Original Paper
Development of indolealkylamine derivatives as potential multi-target agents for COVID-19 treatmentResearch Paper Published on 2023-01-272024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] calmodulin COVID-19 hACE2 Indolealkylamine Melatonin receptors SARS-CoV-2 [DOI] 10.1016/j.ejmech.2023.115152 PMC 바로가기 [Article Type] Research Paper
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug EvaluationArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] COVID-19 hACE2 hiPSC-derived spheroids in vitro drug evaluation. SARS-CoV-2 TMPRSS2 [DOI] 10.1128/spectrum.03490-22 PMC 바로가기