Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 InfectionArticle Published on 2022-10-142022-11-16 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Adequate approach cancers cardiovascular disease chronic disease Chronic diseases communicable disease complementary coronavirus COVID-19 CVD Diabetes Mellitus dietary dietary supplements effective fasting fatty acids feasible hallmark immunomodulatory Importance Inflammation Inflammatory Intermittent intermittent fasting Modification nutraceutical obesity outcome oxidative oxidative stress Patient Polyunsaturated Post-infection quercetin Randomized controlled trial regimen SARS-CoV-2 Selection severe coronavirus disease suggested systemic Therapies time-restricted eating Treatment variant Vitamin vitamins was performed [DOI] 10.3390/nu14204299 PMC 바로가기
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike proteinArticle Published on 2022-09-122022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] activate blocking calprotectin circulating contribute COVID-19 Cytokine storm Delta Dok3 downstream dysregulated immune response effective elevated hallmark Increased JAK2 mechanism neutrophil Neutrophils omicron Prevent Protein recruit S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 severe COVID-19 manifestation Signaling STAT3 susceptible patients target therapy TLR4 variant variants [DOI] 10.3389/fimmu.2022.996637 PMC 바로가기
Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulationArticle Published on 2022-09-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition antibody Antigen C57BL/6 CD4 Complete conditions coronavirus COVID-19 demonstrated Diseases displaying dose effective hallmark highlight IgG immune response immunization in vitro in vivo Lipid-based nanoparticles mice modulated MPLA Nano-multilamellar vesicles promote Protein RBD Receptor binding domain reduced required responses Safe SARS-CoV-2 serum spike subunit Subunit vaccine T-cell Response T-cell responses toxic effect Vaccine Vaccines Vesicle virus-neutralizing antibody [DOI] 10.1016/j.nano.2022.102595 PMC 바로가기
Humoral and adaptive immune responses to the SARS-CoV-2 vaccineArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation Adaptive immune response Adaptive immunity adverse outcome B.1.1.7 B.1.617.2 Blood booster booster dose CD8+ Delta dose hallmark healthy volunteer high affinity humoral humoral immune response Humoral response IFN-γ immune response Infection memory mRNA vaccine neutralizing antibody nine omicron phenotype protective antibody response SARS-CoV-2 SARS-CoV-2 specific antibody SARS-CoV-2 spike antigen SARS-CoV-2 vaccines second vaccination sera Serum level subset T cell the SARS-CoV-2 vaccination Vaccine Wuhan [DOI] 10.1016/j.ijid.2022.06.020 PMC 바로가기
In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Is IFN expression by NK cells a hallmark of severe COVID-19?Research article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] 변종, 치료기술, 치료제, [키워드] addition CD107a clinical form contribute CoV COVID-19 cytolytic cytotoxic activity Cytotoxic granules decrease Defense disease elicited Express expression form Frequency Granule granzyme B groups hallmark Host IFN IFN-α IFN-γ immune responses immune system individual Innate immunity interferons involved Ki-67 Killer cell mechanism Mild natural Natural killers NK cell NK cells pathogenesis of COVID-19 PBMC PBMCs peptide pool profile question recovered COVID-19 patient reduced SARS-CoV-2 severe COVID-19 severity significant increase spike the disease the healthy viruses Volunteer [DOI] 10.1016/j.cyto.2022.155971 [Article Type] Research article
Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on ErythropoiesisArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] SARS, 변종, [키워드] ACE2 Affect Blood blood circulation Bone marrow CD45 CD8 Cell COVID-19 patient COVID-19 patients degranulation Delta disease severity dominant erythropoiesis erythropoiesis. Express expressing expression Frequency function functions granzyme hallmark Hematopoiesis hypoxia immature immunosuppressive immunosuppressive properties Impact impair in vitro investigated omicron oxygen Patient prevalent provide RBC RBCs reactive oxygen specy receptor red blood cell reversed ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly strain subpopulation suppress T cell the SARS-CoV-2 these cell tissues TMPRSS2 Transmissibility variant variants Wuhan Wuhan strain [DOI] 10.1128/spectrum.01730-22 PMC 바로가기
Evidence for deleterious effects of immunological history in SARS-CoV-2SARS-CoV-2에서 면역학적 병력의 유해한 영향에 대한 증거Article Published on 2022-08-242022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] Amino acid amino acid change antibodies binding antibody Antigen antigenic association binding binding assay Binding assays blood sample COVID-19 disease COVID-19 disease severity COVID-19 infections cross-reactive cross-reactivity deleterious effect demonstrated epitope H3N2 hallmark hallmarks homologous identify IgG immunological Immunological memory Infection Influenza influenza A influenza A virus influenza infection influenza strain influenza vaccine Injury Patient presence of antibody Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid sequence severe COVID-19 infections underlie upregulation Vaccine widespread [DOI] 10.1371/journal.pone.0272163 PMC 바로가기 [Article Type] Article
High Monocyte Count Associated with Human Cytomegalovirus Replication In Vivo and Glucocorticoid Therapy May Be a Hallmark of DiseaseArticle Published on 2022-08-242022-11-16 Journal: International Journal of Molecular Sciences [Category] 치료기술, [키워드] caused CD14 Characteristics clinical model/translational medicine clinical response Clinical symptoms CMV comparable correlated corticosteroid therapy count COVID-19 cytomegalovirus cytomegalovirus (CMV) kinetics decrease defined definitions of cytomegalovirus disease described Dexamethasone disease dose glucocorticoid growth hallmark healthy subjects homogeneous homogeneous sample of subjects logarithmic phase of infection Human Increased Infection Infectious disease innate immune innate immune response investigated leukopenia lymphopenia macrophages molecular monocyte monocytes characteristics and analysis monocytosis mononucleosis neutropenia observation onset of fever pathogen detection Patient prodrome Replication Sample Significant steroid subject syndrome tested the median viral infection Viral load viral replication Viremia virome virus virus replication [DOI] 10.3390/ijms23179595 PMC 바로가기