Prospects of halofuginone as an antiprotozoal drug scaffoldarticle Published on 2022-09-302024-09-01 Journal: Drug Discovery Today [Category] 말라리아, [키워드] coccidiosis cryptosporidiosis Febrifugine halofuginone Leishmaniasis malaria toxoplasmosis [Article Type] article
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article
The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α SignalingArticle Published on 2019-04-122024-08-28 Journal: ACS Infectious Diseases [Category] 말라리아, [키워드] drug resistance halofuginone malaria Plasmodium stress response
Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activationArticle Published on 2017-10-102023-06-16 Journal: Drug design, development and therapy [Category] B형 간염, [키워드] AMPK halofuginone Hepatitis B virus Inflammation [DOI] 10.2147/DDDT.S149623 PMC 바로가기
The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatmentArticle Published on 2016-04-022024-08-27 Journal: Bioengineered [Category] 말라리아, [키워드] aminoacyl-tRNA synthetase borrelidin cladosporin halofuginone malaria Plasmodium falciparum