Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks내피 기능 장애는 조절 이상 림프구 반응 및 사이토카인 네트워크와 함께 심각한 COVID-19에 기여합니다Observational Study Published on 2021-12-102022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상, 진단, 치료법, [키워드] activated Activation acute disease Adaptive immunity addition analyses Analysis change Clustering Combination contribute convalescent patient Convalescent patients COVID-19 cytokine disease Disease progression driven by dysfunction dysregulated dysregulation endothelial endothelial injury endothelial integrity expansion flow cytometry granulocyte Granulocytes hallmark hallmarks Hannover ICU patient ICU Patients Immune cell immune cells immune response immune responses immune signature Infectious diseases Inflammatory Inflammatory response Injury involved life-threatening lymphocyte response lymphopenia manifestation medical school microenvironment NK cell observational study plasma protein plasma proteins plasmablast plasmablasts proteomics data regeneration SARS-COV-2 infection SARS-CoV-2-specific antibodies School Seven severe COVID-19 terminally differentiated [DOI] 10.1038/s41392-021-00819-6 PMC 바로가기 [Article Type] Observational Study
Silent Hypoxia in COVID-19: A Case SeriesCovid-19의 조용한 저산소증 : 사례 시리즈Clinical Investigations Published on 2021-11-262022-09-10 Journal: Respiration [Category] MERS, SARS, 치료기술, [키워드] 95% confidence interval acute hypoxemia Admission all subjects Analysis Body Borg BORG scale COPD coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients defined Diagnosis distress Dyspnea emergency room Exacerbation Germany Hannover Healthcare systems Hypocapnia Hypoxemia less median mismatch Multivariate analysis Odds ratio on admission oxygen oxygen demand oxygen saturation pandemic Patient patients PCR respiratory respiratory distress SARS-CoV-2 Sery silent SpO_{2} subject suffered transferred with COVID-19 [DOI] 10.1159/000520083 PMC 바로가기 [Article Type] Clinical Investigations
Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 A phase 1 randomized clinical trialSARS-COV-2에 대한 mRNA- 지질 나노 입자 백신 후보의 안전성 및 면역 원성은 1 상 무작위 임상 시험Clinical Trial Published on 2021-08-102022-08-13 Journal: Wiener Klinische Wochenschrift [Category] MERS, SARS, 임상, 진단, [키워드] Belgium comparable convalescent sera CureVac CVnCoV CVnCoV dose CVnCoV doses CVnCoV vaccination dosage Dosage-dependent increases Dose-response elicited ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Escalation Frequency Germany Ghent group Hannover healthy IgG antibodies IgG antibody immune response immune responses immunogenicity increases in interim analysis intramuscular dose Lipid nanoparticle Lipid nanoparticles LNP Local local AEs Mild moderate Munich Neutralizing antibodies overlapped Phase 1 phase 1 study Placebo platform Protein randomized clinical trial RBD reactogenicity Receptor binding domain response Result S protein S‑protein Safe Safety SARS-CoV-2 SARS-CoV‑2 SARS-CoV‑2 neutralizing titer SARS-CoV‑2 neutralizing titers SARS-CoV‑2 S‑protein second dose sequence-optimized mRNA coding serious AEs seroconverted severity supplementary material systemic adverse event systemic adverse events systemic AEs Tübingen vaccination Vaccine vaccine candidate Volunteer was measured [DOI] 10.1007/s00508-021-01922-y PMC 바로가기 [Article Type] Clinical Trial
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccinationBrief Communication Published on 2021-07-142022-10-29 Journal: Nature Medicine [Category] COVID-19, Fulltext, SARS, [키워드] acute respiratory syndrome approach approved B cells B.1.1.7 B.1.351 BNT162b2 boost booster booster vaccination breadth CD4 CD8 ChAdOx1 Cohort Combination coronavirus coronavirus disease COVID-19 elicited European Frequency Government greater Hannover Healthcare professional Heterologous homologous immune response Immunity individual Medical research MONITOR mRNA-based vaccine mRNA-based vaccines neutralizing antibody Older P.1 variant receive responses against SARS-CoV-2 SARS-CoV-2 variant significantly higher T cell T cells tested Thromboembolic events vaccination Vaccine Vaccines viral vector-based [DOI] 10.1038/s41591-021-01449-9 PMC 바로가기 [Article Type] Brief Communication
Einfluss des COVID-19-Shutdowns auf die Arbeitsleistung einer Universitäts-AugenpoliklinikOriginalien Published on 2021-04-212022-10-28 Journal: Der Ophthalmologe [Category] COVID-19, MERS, SARS, [키워드] Augenheilkunde Cerner city Corporation COVID-19 Hannover material North ophthalmology Outpatient Care Patient management Patientenmanagement Poliklinik relation SARS-CoV-2 Time measurement Zeiterfassung [DOI] 10.1007/s00347-021-01374-9 PMC 바로가기 [Article Type] Originalien
High Incidence of Epileptiform Potentials During Continuous EEG Monitoring in Critically Ill COVID-19 PatientsMedicine Published on 2021-03-262022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] can be used Care Continuous coronavirus disease COVID-19 COVID-19 patient Critical care detect EEGs electroencephalogram Electroencephalography epileptiform epileptiform potentials evaluated Germany Hannover Ill inhalation anesthetics measurement mechanically ventilated patient men monitoring occurred Occurrence Patient Potential Retrospective analysis School Sedation severe COVID-19 [DOI] 10.3389/fmed.2021.613951 PMC 바로가기 [Article Type] Medicine
Peripandemic psychiatric emergencies: impact of the COVID-19 pandemic on patients according to diagnostic subgroupOriginal Paper Published on 2021-02-052022-10-31 Journal: European archives of psychiatry and clinical neuro [Category] COVID-19, MERS, [키워드] affective association Care change consequence control group coronavirus disease COVID-19 COVID-19 pandemic decrease diagnostic disorder drastic effort Fewer patient Hannover immediate effect IMPROVE increase in male measure mental health morbidity MOST outbreak pandemic Patient presentation presenting PROTECT Psychiatric Psychiatric emergency psychiatric emergency department Psychological burden Psychological well-being reduce Schizophrenia School somatoform disorder Substance use disorder suffered Suicidal ideation supplementary material transmission rate Treatment visual hallucination vulnerable patients [DOI] 10.1007/s00406-020-01228-6 PMC 바로가기 [Article Type] Original Paper
Classroom teaching with simulated patients during COVID-19: the communication skills course in the second year of the model medical curriculum HannibaLArticle Published on 2020-12-032022-11-01 Journal: GMS Journal for Medical Education [Category] Coronavirus, MERS, SARS, [키워드] classroom clinical communication and social skills Compliance condition Course COVID-19 COVID-19 pandemic deviate Doctor-patient communication effective Epidemics examination Hannover hygiene Local measure medical education objective Patient question risk of infection School significantly simulated patients [DOI] 10.3205/zma001374 PMC 바로가기 [Article Type] Article
Postinfectious Onset of Myasthenia Gravis in a COVID-19 PatientNeurology Published on 2020-10-062022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] Abbott accompanied Admission Anosmia/ageusia antibody chloride clinical assessment coronavirus COVID-19 COVID-19 patient DiaSorin Diplopia double vision female Fever Germany Hannover Intravenous immunoglobulin limb medical record mild respiratory symptom mild respiratory symptoms Myasthenia neurological neurological manifestation ocular oculomotor paresis Onset Patient persistence Positive test Postinfectious postinfectious myasthenia gravis receptor SARS-CoV-2 School serological test serum suffered Symptom syndrome the patient treated was obtained written Informed Consent [DOI] 10.3389/fneur.2020.576153 PMC 바로가기 [Article Type] Neurology