Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infectionResearch Article Published on 2023-11-302024-09-05 Journal: JHEP Reports [Category] update2024, [키워드] HBV cure Hepatitis B virus Immunotherapy oral antiviral small molecule Toll-like receptor viremic [DOI] 10.1016/j.jhepr.2023.100975 PMC 바로가기 [Article Type] Research Article
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infectionArticle Published on 2022-11-012023-06-11 Journal: Bioorganic & medicinal chemistry letters [Category] B형 간염, [키워드] Chronic hepatitis B (CHB) GST-HG131 HBsAg HBV cure HBV surface antigen inhibitor [DOI] 10.1016/j.bmcl.2022.128977
HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV CureReview Published on 2022-03-222023-06-13 Journal: Viruses [Category] B형 간염, [키워드] antiviral therapy HBV cure Hepatitis B surface antigen (HBsAg) Hepatitis B virus (HBV) [DOI] 10.3390/v14040657 PMC 바로가기 [Article Type] Review
The price tag of a potential cure for chronic hepatitis B infection: A cost threshold analysis for USA, China and AustraliaArticle Published on 2022-01-012023-06-11 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] access Affordability antiviral therapy cost-effectiveness HBV cure [DOI] 10.1111/liv.15027
Recent Progress and Future Prospective in HBV Cure by CRISPR/CasReview Published on 2021-12-212023-06-02 Journal: Viruses [Category] B형 간염, [키워드] Chronic hepatitis B (CHB) CRISPR-Cas9 gene editing HBV cure Hepatitis B virus (HBV) [DOI] 10.3390/v14010004 PMC 바로가기 [Article Type] Review
Functional Exhaustion of HBV-Specific CD8 T Cells Impedes PD-L1 Blockade Efficacy in Chronic HBV InfectionOriginal Research Published on 2021-09-132023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Chronic HBV infection Exhaustion HBV cure LAG3 PD-L1 blockade [DOI] 10.3389/fimmu.2021.648420 PMC 바로가기 [Article Type] Original Research
Covalently closed circular DNA: The ultimate therapeutic target for curing HBV infectionsReview Published on 2021-09-012023-06-12 Journal: Journal of hepatology [Category] B형 간염, [키워드] cccDNA Chronic Hepatitis B Direct-acting antivirals HBV cure [DOI] 10.1016/j.jhep.2021.05.013 [Article Type] Review
Is there any need for new, long-acting nucleos(t)ide analogues for the treatment of hepatitis B infection?Editorial Published on 2021-05-012023-06-09 Journal: Journal of hepatology [Category] B형 간염, [키워드] Chronic Hepatitis B Covalently-closed-circular DNA HBV cure Long-lasting effect nucleos(t)ide analogues [DOI] 10.1016/j.jhep.2021.01.038 [Article Type] Editorial
Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA FormationReview Published on 2021-04-262023-06-02 Journal: Viruses [Category] B형 간염, [키워드] DNA repair DNA synthesis HBC HBV HBV cure HBVcccDNA nuclear import nuclear pore [DOI] 10.3390/v13050757 PMC 바로가기 [Article Type] Review
Hepatitis B virus cccDNA: Formation, regulation and therapeutic potentialReview Published on 2020-08-012023-06-12 Journal: Antiviral Research [Category] B형 간염, Fulltext, [키워드] cccDNA eradication. drug target HBV cccDNA minichromosome HBV cure host-virus interaction transcriptional regulation [DOI] 10.1016/j.antiviral.2020.104824 PMC 바로가기 [Article Type] Review