An atlas of the blood virome in healthy individualsarticle Published on 2022-11-172024-09-02 Journal: Virus research [Category] 대상포진, [키워드] Blood healthy individuals Metatranscriptomic sequencing virome [DOI] 10.1016/j.virusres.2022.199004 PMC 바로가기 [Article Type] article
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Gastroenterology & Hepatology [Category] SARS, 진단, [키워드] adjusted age All participant anti-SARS-CoV-2 anti-TNF antibody Antibody binding antibody concentration Antibody concentrations approved available data boost booster case-control study combination therapy Concentration control group COVID-19 COVID-19 vaccine Diagnosis disease dose Evidence first dose geometric mean geometric mean ratio group groups had no healthy control healthy individuals heterologous vaccine homologous IBD Immunosuppressed immunosuppressed patient immunosuppressive Immunosuppressive treatment Infection Inflammatory bowel disease jak inhibitors multicentre multivariable nine no significant difference Older Older age participant Patient patients treated Pfizer Primary outcome receiving Receptor binding domain recipient recruited reduced regimen response S1 RBD SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination significantly significantly lower Support T-cell Response T-cell responses the healthy therapy Tofacitinib Treatment ulcerative colitis Vaccine vaccine dose vaccine doses vaccine-induced antibody response VIP were measured [DOI] 10.1016/S2468-1253(22)00274-6 PMC 바로가기
Immunogenicity and efficacy of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysisArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] affected Antibody titer booster vaccination both groups Cochrane Library comparable COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy healthy controls healthy individuals HIV immunogenicity IMPROVE in healthy individuals inclusion criteria increased risk less Messenger RNA Meta-analysis participant patients PLWH random-effect reduced risk ratio SARS-CoV-2 SARS-CoV-2 antibody searched second dose Seroconversion severe COVID-19 significantly subject systematic review vaccination vaccine dose was performed with HIV [DOI] 10.1016/j.ijid.2022.10.005 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls-a prospective cohort studyArticle Published on 2022-10-052022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI analyzed anti-RBD antibodies binding antibody antibody level blood sample bowel collected combination treatment Control controls COVID-19 declined defined disease dose enrolled Factor greater healthy healthy control healthy individuals Humoral immunity identify Immune-mediated inflammatory disease immunosuppressive Immunosuppressive medication Inflammatory bowel disease inhibitor initial interval median Multivariable regression Necrosis participant Patient patients persistence prospective cohort study Protein provided psoriatic arthritis RBD reduction reduction in Rheumatic diseases rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine serologic Serologic response spike spondyloarthritis Support the receptor-binding domain the SARS-CoV-2 Therapies therapy ulcerative colitis vaccination vaccine dose [DOI] 10.1186/s12916-022-02587-8 PMC 바로가기
Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomesArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] actin-binding protein Analysis anti-Spike IgG antibody blood sample Clinical management clinical parameter collected Combination Control correlated COVID-19 COVID-19 disease COVID-19 hospitalization COVID-19 negative COVID-19 patient COVID-19 severity CRP CRP-C-reactive protein cytokine death develop disease disease pathogenesis expression ferritin Gelsolin greater health system healthy individuals Hospitalization hospitalized COVID-19 patient IgG IL-6 IMPROVE innate immune Intervention involved IP-10 Laboratory longitudinal M-CSF marker outcome outcomes plasma platform predict profile prognostic Prognostic marker reduced Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SEM significantly utility viral infections while [DOI] 10.3389/fimmu.2022.1011084 PMC 바로가기
SARS-CoV-2 Omicron: Light at the End of the Long Pandemic Tunnel or Another False Dawn for Immunodeficient Patients?Article Published on 2022-09-012022-11-15 Journal: The journal of allergy and clinical immunology. In [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Antibody evasion appear caused COVID-19 COVID-19 infection COVID-19 vaccine CVID dawn deaths End Fatality rate form group healthy individuals Hospitalization immunodeficiency immunodeficient patients implication individual innate immune less LIGHT Long lung damage morbidity offer offered omicron outcomes pandemic Patient Perspective physical Psychiatric reduced risk respond risk SARS-CoV-2 SARS-CoV-2 variants severe disease survivor T-cell the SARS-CoV-2 those with comorbidity Tunnel variant [DOI] 10.1016/j.jaip.2022.06.011 PMC 바로가기
Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens Research Published on 2022-08-112022-10-05 Journal: Nature Communications [Category] SARS, 치료기술, [키워드] Analysis Antigen BNT162b2 CD4 T-cell CD8 T-cell Cellular immune response ChAdOx1-nCoV-19 Cohort Combination combinations Comparative COVID-19 vaccine FIVE healthy individuals Heterologous highest homologous humoral Immunity induce mRNA-1273 reactogenicity regimen regimens SARS-CoV-2 T-cell the vaccine vaccination Vaccination strategy Vaccine [DOI] 10.1038/s41467-022-32321-0 [Article Type] Research
Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccinationJanus kinase inhibitor로 치료받은 류마티스 관절염 환자, BNT162b2 백신 접종 후 체액성 면역 반응 감소Article Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] Activation alteration analysed anti-spike antibodies anti-Spike IgG Anti-spike IgG antibody antibodies antibody antibody titres Arthritis B cell B cell responses B cells B-lymphocytes BNT162b2 BNT162b2 vaccine collected COVID-19 COVID-19 vaccine determine dose Efficacy elicited ELISA expression germinal centre healthy individual healthy individuals humoral humoral immune response Humoral immunity IgA antibody individuals JAK inhibitor Janus kinase Janus kinase inhibitor Janus kinase inhibitors less mRNA-based COVID-19 vaccine neutralization activity Neutralization assay neutralization capacity Patient patients patients treated plasma plasma sample quantitative PCR reduced Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-COV-2 infection shown Spike protein suppressed the SARS-CoV-2 the vaccine titre treated vaccination Vaccine Vaccines Virus neutralization was reduced was used [DOI] 10.1093/rheumatology/keab879 PMC 바로가기 [Article Type] Article
A colorimetric electronic tongue for point-of-care detection of COVID-19 using salivary metabolitesResearch article Published on 2022-08-012022-10-05 Journal: Talanta [Category] 치료기술, [키워드] Accuracy can be used category change colorimetric detection complexes Concentration COVID-19 COVID-19 patients cured detect diabete diagnose Donor Efficiency Evidence healthy healthy individuals identify individuals Kidney disease marker metabolite metabolomics Paper-based device participant Patient point-of-care receptor recorded rRT-PCR Saliva salivary Sensor array smoker tongue unique Viral load [DOI] 10.1016/j.talanta.2022.123537 [Article Type] Research article